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1. Stronger selective constraint on downstream genes in the oxidative phosphorylation pathway of cetaceans | |||
Tian Ran,Xu Shixia,Chai Simin,Yin Daiqing,Harold Zakon,Yang Guang | |||
Biology 21 November 2017 | |||
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Abstract:The oxidative phosphorylation (OXPHOS) signaling pathway is an efficient way to produce energy of adenosine triphosphate (ATP), which is most crucial for sustaining an energy supply for cetaceans in a hypoxic environment. Several studies have shown that natural selection may shape the evolution of the genes involved in OXPHOS. However, how network architecture drives OXPHOS protein sequence evolution remains poorly explored. In this project, we investigated the evolutionary patterns of genes in the OXPHOS signaling pathways across six cetacean genomes within the framework of functional network. Our results show that a negative correlation was inferred between the strength of purifying selection and pathway position. This result indicates the downstream genes were subjected to stronger evolutionary constraints, which may be because of the dual function of ATP synthase required to transduce signals of the OXPHOS pathway. We also found that there was a positive correlation between codon usage bias and ω, and a negative correlation with dS, indicating a stronger selective constraint on genes (with less biased codon usage) along the OXPHOS signaling pathway is attributable to an increase in the rate of synonymous substitution. Surprisingly, there was no significant correlation between the protein-protein interactions (PPIs) and the evolutionary estimates, implying that highly connected enzymes showing greater evolutionary constraint may not be a more general mechanism. Compared with that observed for terrestrial mammals, we found that the signature of positive selection detected in five genes (ATP5J, LHPP, PPA1, UQCRC1, UQCRQ) was cetacean-specific, reflecting the importance of OXPHOS for survival in hypoxic, aquatic environments. | |||
TO cite this article:Tian Ran,Xu Shixia,Chai Simin, et al. Stronger selective constraint on downstream genes in the oxidative phosphorylation pathway of cetaceans[OL].[21 November 2017] http://en.paper.edu.cn/en_releasepaper/content/4742252 |
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