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1. Nanomaterials in Bone Regeneration | |||
TIAN Taoran,CAI Xiaoxiao | |||
Basic Medicine 05 December 2015 | |||
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Abstract:Regenerative medicine is gathering more and more interests as it circumvents limitations and imperfections of traditional graft therapies such as autograft and xenograft. As for the part and parcel of regenerative medicine, the prosperous development in material science boost reciprocal approaches in bone regeneration. Nowadays, the refinement of materials leads our sights into a scale of nano. Nanomaterials, owing to their unique biomimic properties and unsurpassed surface merits, brought profound innovations to various fields, including bone tissue engineering. Studies have been designed to reveal interactions between bone tissues and nanomaterials, and thereby explore the potential applications in the same front. In this review, we summarized recent literatures, coming up with the basic characteristics of nanomaterials and their superiorities to traditional materials, and following with their unique features and applications in the process of bone regeneration. By the comparison and analyzing, we hope to purpose a comprehensive understanding over nanomaterials applied in bone regeneration. | |||
TO cite this article:TIAN Taoran,CAI Xiaoxiao. Nanomaterials in Bone Regeneration[OL].[ 5 December 2015] http://en.paper.edu.cn/en_releasepaper/content/4669279 |
2. Local Delivery of Flavopiridol in PLGA Nanoparticles Improves the Repair of Spinal Cord Injury by Inhibiting Astrocyte Growth and Inflammatory Factor Synthesis | |||
REN Hao | |||
Basic Medicine 25 April 2014 | |||
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Abstract:The cell cycle inhibitor flavopiridol was previously shown in animal models to improve SCI recovery. However, the systematic dosage of flavopiridol is with side effects and the mechanism is not clear. This study aims to develop a strategy for local delivery of flavopiridol and investigate its mechanisms of function as well. Poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) was used for the sustained delivery of flavopiridol. The spinal cords were right-hemisectioned and NPs were administered into the injury site. Transparent spinal cord technology was applied for the three-dimensional observation of the anterograde tracing. The results showed that flavopiridol NPs had a susteined release of up to 3 days in vitro. Flavopiridol NPs significantly decreased inflammatory factor synthesis of astrocytes, including tnf-alpha, il-1beta, and il-6, while the il-10 expression was elevated. In-vivo study demonstrated that flavopiridol NPs decreased inflammatory expression and glial scarring, and facilitated neuronal survival and neural transmitting. Cavitation volume was decreased by proximately 90%. Administration of flavopiridol NPs also improved the motor recovery of injured animals. These findings illustrated that local delivery of flavopiridol in PLGA NPs improved SCI recovery through inhibiting astrocyte growth and inflammatory factor synthesis. | |||
TO cite this article:REN Hao. Local Delivery of Flavopiridol in PLGA Nanoparticles Improves the Repair of Spinal Cord Injury by Inhibiting Astrocyte Growth and Inflammatory Factor Synthesis[OL].[25 April 2014] http://en.paper.edu.cn/en_releasepaper/content/4594779 |
3. Investigation of Adhesion and Proliferation Behavior of Myoblast and Bacteria on Micro-pattern Chip | |||
Bao Chongyun,Xiao Yu | |||
Basic Medicine 06 March 2014 | |||
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Abstract:Surface microstructure of implant materials is an essential factor to determine the adhesion and proliferation behaviors of cells and bacteria. However, it is still unclear which kind of morphological characteristics plays dominant roles. For this purpose, hydroxyapatite (HA) and polydimethylsiloxane (PDMS) chips were prepared firstly with different types of microstructures and the C2C12 cells were seeded on these chips to investigate which microstructures could affect the behavior of cells. Next, Staphylococcus aureus(S.a) and Porphyromonas gingivalis(P.g) were cultured on the PDMS matrix, respectively, to analyze the performance of bacteria on varied surface microstructures. The results illustrated much more C2C12 cells seeded on the HA chips than the PDMS replicas, indicating HA are more suitable for the cell's culture. Moreover, further observation and comparison represented both HA and PDMS samples illustrated a similar trend that the cells mainly adhered and proliferated on the submicron structure region rather than microstructure region. By contrast, the bacteria were significantly preferable to the microstructure regions. Overall, on account of different performance of cells and bacteria, we drew the conclusion that the surface roughness (RA) of implant materials should be manufactured in submicron-scale rather than micro-scale for improving the biocompatibility of biomaterials. | |||
TO cite this article:Bao Chongyun,Xiao Yu. Investigation of Adhesion and Proliferation Behavior of Myoblast and Bacteria on Micro-pattern Chip[OL].[ 6 March 2014] http://en.paper.edu.cn/en_releasepaper/content/4589112 |
4. Effect of micro-structure on the bio-adhesion of oral bacteria | |||
Bao Chongyun,Xiao Yu | |||
Basic Medicine 06 March 2014 | |||
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Abstract:Ihe micro-morphology of local micro-environment affects the adhesion, proliferation, differentiation and other acts of cells and microorganisms. To compare the adsorptive behavior of graphite powder and adhesive behavior of microbe on micro-structures, we prepared micro-structures on hydroxyapatite (HA) with different sizes and shapes. The results showed that Candida albicans was mostly prone to adhere onto 5 μm micro-structures, while 10-20 μm graphite powder was mostly prone onto adsorb to 10 μm and 20 μm micro-structures. The adhesion of Streptococcus mutans which grew in a chain was almost not affected by the size or shape of micro-structures, however, its proliferation was obstructed by micro-structures. | |||
TO cite this article:Bao Chongyun,Xiao Yu. Effect of micro-structure on the bio-adhesion of oral bacteria[OL].[ 6 March 2014] http://en.paper.edu.cn/en_releasepaper/content/4589077 |
5. The Adsorption and Release of DNA by Mesoporous Silica Materials with Different Pore Diameters. | |||
SUN Yan,YAN Tingsheng,LIU Xianbin | |||
Basic Medicine 18 March 2013 | |||
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Abstract:Safe and efficient vector systems played a crucial role in the transgenic technology. Mesoporous silica (MS) materials, which can be modified with functional groups, have the potential of being used as good vectors. In this study, the pore diameters of synthetic materials were from 2.3 nm to 5.0 nm and the samples have a good dispersion. The MS meterials with different pore diameters were successfully amino-modified and studies about the adsorption and release properties of DNA were carried out. The sample N-MCM-41-14 which had the smallest pore 2.3 nm could only adsorb DNA fragment shorter than 750 bp. The sample N-SBA-15 with 5.0 nm pore could adsorb all DNA fragment shorter than 5000 bp. The pore size of MS materials had important implications on the DNA adsorption rate and the maximum adsorption capacity. However, pore size of the materials had little effect on the release rate of DNA. In sum, MS materials with different pore diameters had different adsorption properties of DNA, and could be as prefect gene delivery systems. | |||
TO cite this article:SUN Yan,YAN Tingsheng,LIU Xianbin. The Adsorption and Release of DNA by Mesoporous Silica Materials with Different Pore Diameters.[OL].[18 March 2013] http://en.paper.edu.cn/en_releasepaper/content/4530263 |
6. Effects of Polyethylenimines on the Morphology and Structure of Human Red Blood Cells | |||
CAI Shushan,GUO Rui,LIU Zonghua,ZHU Yi,CHEN Lili,ZHANG Yuanming | |||
Basic Medicine 15 February 2012 | |||
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Abstract:Of all synthetic polycations, polyethylenimine (PEI) is one of the most effective gene carriers in vitro and vivo because of its unique combination of high charge density and enhanced "proton spong effect" in endolysosome. When PEI is used as gene carriers in vivo, it gets access to systemic circulation sooner or later. In this perspective, it is important to study their effects on blood. The aim of this work was to report the effects of different molecular weight (MW) of PEIs on human red blood cells (RBCs), one of the blood components. Specifically, RBC hemolysis induced by PEIs was assessed, and the RBC morphology was analyzed by optical microscopy (OM), scanning electron microscopy (SEM), atomic force microscopy (AFM) and transmission electron microscopy (TEM). No obvious hemolysis was observed with PEI-0.6 and PEI-1.8 at concentrations <10 mg/mL and PEI-10 at concentrations < 0.01 mg/mL. Morphological evaluation by OM and SEM showed that, high concentrations and high MW of PEI interact with RBCs, leading to RBCs adhesion, aggregation, or both. The surface roughness of the RBCs increased along with increasing PEI-10 concentration, as observed by AFM. The internal structure of the RBCs aggregation analyzed by TEM showed that the cells aggregated and had a capacity to deform. In conclusion, PEIs caused RBC membrane disruption, morphology change, and hemolysis in a MW- and concentration-dependent manner. | |||
TO cite this article:CAI Shushan,GUO Rui,LIU Zonghua, et al. Effects of Polyethylenimines on the Morphology and Structure of Human Red Blood Cells[OL].[15 February 2012] http://en.paper.edu.cn/en_releasepaper/content/4466685 |
7. Rapid biomimetic mineralization of chitosan sponges with a facile method in ethanol/water mixed solution | |||
Li Lihua ,Zhou Changren | |||
Basic Medicine 18 May 2010 | |||
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Abstract:Mineralization of biopolymers is a hot topic and a promising method for tissue engineering. In this study, biomimetic mineralization of chitosan sponges was performed in a large quantity with a rapid and facile approach. The calcium phosphate apatite was co-precipitated as the precursor for the formation of hydroxyapatite in mixed water-ethanol solution. The component and morphology of the apatite and the nanocomposite hybrid sponges were measured with XRD, TEM, FTIR and ESEM. The mechanism of nucleation and growth of crystals were discussed as well. Results revealed that chitosan matrix improved the crystalline quality of hydroxyapatite (HAP) crystals. With elongation of mineralization time, the mineral layers on the outer surface and inner section of chitosan sponges increased. The chitosan sponge or the microenvironment around it promoted the crystallites quality of HAP phase. Furthermore, the compressive strength and modulus of the HAP-chitosan bio-composites increased to 0.55 MPa and 29.29± 1.25 MPa respectively. Such one-pot approach might be extended to the mineralization of other biopolymers and will have a very broad application in the future. | |||
TO cite this article:Li Lihua ,Zhou Changren . Rapid biomimetic mineralization of chitosan sponges with a facile method in ethanol/water mixed solution[OL].[18 May 2010] http://en.paper.edu.cn/en_releasepaper/content/4372783 |
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