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	1. Treatment of primary pulmonary malignant fibrous histiocytoma: case report and literature Review
	XU Song,Li Xiongfei,SHI Tao,REN Fan,YANG Fan,Liu Renwang,REN Dian,DONG Shangwen,FAN Haiyang,WEI Sen,CHEN Gang,CHEN Jun
	Clinical Medicine 15 April 2017
	Show/Hide Abstract \| Cite this paper︱Full-text: PDF (4K B)

	Abstract:Objective: Malignant fibrous histiocytoma (MFH) is an aggressive soft tissue sarcoma which can occur in various organs. However, primary MFH arising from lung is quite rare. Method: Herein we reported a case of 61-year-old male with primary pulmonary MFH and explore the underlying mechanisms by next generation sequencing. Results: Five gene mutations, including TSC2, ARID1B, CDK8, KDM5C and CASP8, were detected and the mTOR inhibitor might be an efficient treatment for this patient. In addition, we reviewed in the English literature approximately 36 case reports of primary pulmonary MFH since 1979 and summarized the clinical features and prognosis of this rare pulmonary malignant tumor.Conclusion:MFH is not sensitive to chemo- and radio-therapy. Once the diagnosis is confirmed, a complete surgical resection is necessary. Target therapy by mTOR inhibitors might be a promising treatment.
	TO cite this article:XU Song,Li Xiongfei,SHI Tao, et al. Treatment of primary pulmonary malignant fibrous histiocytoma: case report and literature Review[OL].[15 April 2017] http://en.paper.edu.cn/en_releasepaper/content/4725565


	2. Over-expression of LAPTM4B-35 and VEGF is related to poor prognosis in local advanced cervical carcinoma
	Fanling Meng,Pan Shang,Hongtao Song,Ge Lou
	Clinical Medicine 04 June 2016
	Show/Hide Abstract \| Cite this paper︱Full-text: PDF (4K B)

	Abstract:Objectives: Patients with locally advanced cervical cancer (LACC) are difficult to treat. The purpose of this study is to investigate lysosome-associated protein transmembrane 4?-35 (LAPTM4B-35) and vascular endothelial growth factor (VEGF) expression in LACC and evaluate their clinicopathological and prognostic significance. Methods: The expression of LAPTM4B-35 and VEGF proteins was analyzed by immunohistochemistry in 119 LACC and 40 normal cervical specimens. Results: LAPTM4B-35 and VEGF were expressed in 73.9% and 75.6% of cervical cancer, respectively, which are higher than the normal cervical tissues. LAPTM4B-35 expression was positively correlated with the expression of VEGF. The expression of LAPTM4B-35 and VEGF was significantly correlated with FIGO stage, Histological grade and lymph node metastasis (P<0.05). Kaplan-Meier analysis showed that LACC patients with high expression of LAPTM4B-35 and VEGF exhibited poor overall survival (OS) and disease-free survival (DFS) (P<0.05). Conclusions: We demonstrate that LAPTM4B-35 correlates with VEGF and is a poor prognostic factor in local advanced cervical cancer.
	TO cite this article:Fanling Meng,Pan Shang,Hongtao Song, et al. Over-expression of LAPTM4B-35 and VEGF is related to poor prognosis in local advanced cervical carcinoma[OL].[ 4 June 2016] http://en.paper.edu.cn/en_releasepaper/content/4693517

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