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1. Teriparatide in the treatment of osteoradionecrosis of the jaws: a controlled clinical trial | |||
Hao Nie,Weihong Wang,Biao Xu,Jingyi Li,Yu Liu,Yemei Qian | |||
Clinical Medicine 14 February 2023 | |||
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Abstract:Objective: To investigate the clinical therapeutic effect of teriparatide on osteoradionecrosis of the jaws (ORNJ). Materials and Methods: From May 2021 to November 2022, altogether 17 patients with ORNJ who consulted were divided into teriparatide and control groups. Following basic treatment including lesion removal, teriparatide group received subcutaneous administration of the drug (20ug/d) for two months, whereas control group received basic treatment only (including lesion excision.). Finally, patients underwent wound healing and jaw bone regeneration in the region of necrotic bone under observation. Results: There were seven patients in control group and ten in teriparatide group. In the course of treatment, two patients in teriparatide group withdrew from the research due to drug allergy and stroke, while the remaining eight experienced no side effects. A significant amount of new bone regeneration was observed in the region of dead bone in five patients in the teriparatide group, and their healing rate (37.5%) was higher than that of control group (14.2%) (P<0.001). Conclusion: Teriparatide can improve wound healing and new bone regeneration in patients with ORNJ after the removal of moribund bone from ORNJ. | |||
TO cite this article:Hao Nie,Weihong Wang,Biao Xu, et al. Teriparatide in the treatment of osteoradionecrosis of the jaws: a controlled clinical trial[OL].[14 February 2023] http://en.paper.edu.cn/en_releasepaper/content/4759022 |
2. Measurement and correlation analysis of upper airway and mandible, hyoid in patients with bilateral anterior disc displacement | |||
Hou Yijun,Pan Xiaojing | |||
Clinical Medicine 23 March 2022 | |||
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Abstract:Objective: To evaluate the presence of upper airway stenosis in patients with bilateral anterior disc displacement, and to further demonstrate the relationship between temporomandibular joint, airway, and hyoid bone. Methods: 64 patients with bilateral anterior disc displacement shown by CBCT in the joint specialty of Stomatological Hospital of Lanzhou University from June 2020 to August 2021 were selected as the patient group, 65 patients with normal joints diagnosed by arthrologists were selected as the control group. The included patients were 18-44 years old, with normal BMI index and skeletal class I. The number of patients with high angle and low angle in the experimental group was the same as that in the control group. First, Dolphin11.8 was used to measure joint space, airway volume, and cross-sectional area. It also reconstructed lateral cranial radiographs were used to measure the parameters of the mandibular and hyoid bone. last, we analyzed the correlation. Results: There was no difference in segmentation parameters among all patients. In patients with bilateral anterior disc displacement, the airway is narrow, the mandible retracts, and the hyoid bone is lower and more posterior. The linear ratio of condylar sagittal position (LR) was correlated with the airway volume of palatopharynx and glossopharynx, and with the length of the mandibular body and the sagittal position of mandible. Conclusions: Patients with bilateral anterior disc displacement and patients with OSAHS show similar changes in the position of mandible and hyoid bone. When meeting patients with joint problems, stomatologists should pay attention to asking them whether they have problems with airway obstruction. | |||
TO cite this article:Hou Yijun,Pan Xiaojing. Measurement and correlation analysis of upper airway and mandible, hyoid in patients with bilateral anterior disc displacement[OL].[23 March 2022] http://en.paper.edu.cn/en_releasepaper/content/4757016 |
3. Biofilm formation of an oral symbiotic bacteria and its effect on common oral pathogens | |||
Hui Wang,Zhanhai Yu,Zhiqiang Li,Jianye Zhou | |||
Clinical Medicine 20 October 2021 | |||
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Abstract:As a kind of symbiotic bacteria, Streptococcus sanguinis is widely distributed in the oral cavity, mainly including the surface of teeth, oral mucosa , and human saliva. Besides, as one of the initially colonized strains, Streptococcus sanguinis is the pioneer and key role in the development of oral biofilms, which is believed to resist pathogens and promote oral health. And the evolution of its biofilms plays an important part in both bacterial adaptations to the environment and invasion of the host. This paper discusses the early colonization mechanism of Streptococcus sanguinis and its interaction with pathogens related to caries and periodontitis, and finally, summarizes the methods of biofilm research, hoping to provide ideas for the follow-up research in this field. | |||
TO cite this article:Hui Wang,Zhanhai Yu,Zhiqiang Li, et al. Biofilm formation of an oral symbiotic bacteria and its effect on common oral pathogens[OL].[20 October 2021] http://en.paper.edu.cn/en_releasepaper/content/4755640 |
4. Evaluation of alveolar bone density and thickness of the mandibular molars in patients with periodontitis | |||
ABEER A AL-Sosowa,MOHAMMED N Alhajj,EHAB A.Abdulghani,ZHE He,PANG Yunqing,LI Na,WANG Jing | |||
Clinical Medicine 29 May 2021 | |||
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Abstract:Background: Periodontitis is the main cause of tooth loss in adults and is closely related to many diseases throughout the body. The main purpose of this study is to use Cone beam computed tomography (CBCT) to study the difference in alveolar bone density and thickness of mandibular molars in patients with periodontitis in Gansu, in order to provide guidance for treatment plans for patients with periodontitis. Methods: CBCT was used to evaluate the buccal and lingual alveolar bone loss, bone density and bone thickness of 668 mandibular molars (344 periodontal healthy teeth and 324 periodontitis teeth) of 167 subjects. Compare the changes in alveolar bone density and thickness between healthy individuals and patients with periodontitis, and explore its relationship with tooth type, tooth surface, root position, degree of bone loss, age and gender. Results: The alveolar bone density and thickness of healthy individuals were higher than those of periodontitis patients, but only the buccal bone thickness was statistically significant (P<0.01). There were significant differences in alveolar bone density and thickness between the left and right molars, between the first molar and the second molar, and between the mesial and distal surfaces of the molars between healthy periodontal patients and patients with periodontitis (P<0.01) . For periodontitis patients, the buccal bone density and thickness between different degrees of alveolar bone loss have significant differences (P<0.01). There were significant differences in alveolar bone density between periodontal healthy individuals and periodontitis patients of different genders and ages (P<0.01). However, the thickness of the alveolar bone of periodontitis patients of different genders and ages were significantly different (P<0.01). Gender had a significant effect on the lingual alveolar bone density of periodontal healthy individuals and periodontitis patients (P<0.01). The tooth type, tooth surface and tooth root mesial and distal faces had significant effects on the alveolar bone thickness of periodontal healthy individuals and periodontitis patients (P<0.01). Conclusion: The thickness of alveolar bone in healthy periodontal patients is significantly higher than that in patients with periodontitis. The alveolar bone density and thickness of periodontal healthy individuals and periodontitis patients are affected by many factors. | |||
TO cite this article:ABEER A AL-Sosowa,MOHAMMED N Alhajj,EHAB A.Abdulghani, et al. Evaluation of alveolar bone density and thickness of the mandibular molars in patients with periodontitis[OL].[29 May 2021] http://en.paper.edu.cn/en_releasepaper/content/4755079 |
5. Comparative study of the treatment effects with FR III and Sander III appliances in children with Class III malocclusion | |||
ZHAO Wei,AN Xiaoli | |||
Clinical Medicine 02 May 2019 | |||
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Abstract:Purpose: To evaluate and compare the skeletal and facial changes of children with mild skeletal Class III malocclusion following the treatment of the Function Regulator III appliance and the Sander III appliance. Materials and methods: The study sample consisted of 40 children presenting skeletal Class III malocclusion. The group of patients treated with the Function Regulator III appliances (FR-III) consisted of 20 subjects with a mean age of 7.615±0.9996 years. The group of patients treated with the Sander III appliances (SD-III) consisted of 20 subjects with a mean age of 7.68±1.0665 years. Lateral cephalograms were obtained immediately before initiation and after completion of the treatment. Twenty-one variables were used for the analysis of skeletal and lateral profile changes. The non-parametric test was utilized to evaluate the presence of significant changes (P < 0.05). Results: Cephalometric analysis showed that the ANB angle increased by 4.05o in the SD-III group, compared with 1.46o in the FR-III group (p < 0.0001). There was 1.93o and 5.75o increase in GoGn-SN and FMA respectively in SD-III group, and the trends in FR-III group were similar, but there was no statistical difference between the two groups(p>0.05). Conclusion: SD-III is suitable for the maxillary deficiency of skeletal Class III malocclusion with low or average mandibular plane angle, rather than the high angle patients with apparent mandibular overgrowth. FR-III is suitable for the functional crossbite with low or average angle and the patients of mild skeletal Class III malocclusion with normal upper and lower jaws. | |||
TO cite this article:ZHAO Wei,AN Xiaoli. Comparative study of the treatment effects with FR III and Sander III appliances in children with Class III malocclusion[OL].[ 2 May 2019] http://en.paper.edu.cn/en_releasepaper/content/4748845 |
6. The role of sclerostin and receptor activator of nuclear factor κB ligand/osteoprotegerin signalling pathways in chronic periodontitis | |||
Wang Tiantian,Yuan Xuemin,Zhang Xingxing,LI Yue,Pang Yunqing,Wang Xuemei,Wang Jing | |||
Clinical Medicine 20 April 2018 | |||
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Abstract: Background: Chronic periodontitis are associated with the resorption of alveolar bone. Sclerostin participates in the process of bone resorption through the RANKL/RANK/OPG pathway. However, the mechanism of bone resorption and sclerostin expression in chronic periodontitis is unclear. In this study, the purpose was to evaluate the mechanism of action of sclerostin in human chronic periodontitis. Methods: Saliva and gingival crevicular fluid were collected from systemically healthy non-periodontitis (n=30) and chronic periodontitis subjects (n=30). The protein levels of sclerostin, RANKL and OPG in saliva and gingival crevicular fluid were detected by enzyme linked immunosorbent assay (ELISA). Results: Sclerostin levels in saliva and gingival crevicular fluid were significantly higher in the chronic periodontitis group than the non-periodontitis group (P < 0.05). The level of OPG is significantly lower but the RANKL level and the ratio of RANKL/OPG was significantly higher than that in the non-periodontitis group in saliva and gingival crevicular fluid (P < 0.05). Sclerostin levels in saliva and gingival crevicular fluid were significantly positively correlated with PD, CAL and BOP (P < 0.05). Conclusions: The results showed that sclerostin may affect bone tissue damage of chronic periodontitis through RANKL/RANK/OPG pathway. It will provide a new insight into the diagnosis and treatment of periodontitis patients. | |||
TO cite this article:Wang Tiantian,Yuan Xuemin,Zhang Xingxing, et al. The role of sclerostin and receptor activator of nuclear factor κB ligand/osteoprotegerin signalling pathways in chronic periodontitis[OL].[20 April 2018] http://en.paper.edu.cn/en_releasepaper/content/4744647 |
7. Current approaches and challenges for regenerative endodontic therapy | |||
ZHENG Yi,GAO Bo | |||
Clinical Medicine 19 May 2017 | |||
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Abstract:Immature teeth are susceptible to infections due to trauma, anatomic anomalies, and caries. Traditional endodontic therapy such as apexification and pulpotomy have several disadvantages, including the unpredictability of apical barrier formation and the long duration of treatment. Regenerative endodontic therapy provides an alternative treatment approach that builds on the principles of regenerative medicine and biological tissue engineering process. This process includes two key parts: one is pulp revascularization, regenerating new vital pulp tissue in the root canal to promote continuous root growth and development; the other is tissue engineering, stem cells under the induction of suitable biological active scaffold and growth factors promote pulp dentin complex regeneration. The aim of the therapy is not only for a resolution of pain, inflammation and periapical lesions, but also for regenerating functional pulpal tissue to promote root development in terms of both length and thickness. This review summarizes the recent concept of pulp revascularization in the treatmet of immature teeth with nonvital pulps and the emerging research on pulp tissue engineering, and put insight of the challenges and clinical outcomes of regenerative endodontic therapy. | |||
TO cite this article:ZHENG Yi,GAO Bo. Current approaches and challenges for regenerative endodontic therapy[OL].[19 May 2017] http://en.paper.edu.cn/en_releasepaper/content/4735088 |
8. PTPN2, a potential theraputic target for diabetic patients withe periodontitis | |||
WANG Qi,LI Hao,XIA Sisi,ZHOU Xinyi,ZHANG Peng,LI Shuan,GONG Hong,DING Yi | |||
Clinical Medicine 15 May 2016 | |||
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Abstract:,eriodontitis, a worldwide complication of diabetes, often contributes to severe destruction of the tooth-surrounding tissue and tooth loss. However, existing therapeutic approaches for periodontitis only lead to variable and unpredictable clinical results due to a number of problems caused by immune dysfunction, aberrant inflammatory reactions and hyperglycemia in diabetic patients. T-cell protein tyrosine phosphatase (TCPTP),also known as PTPN2,is a ubiquitous tyrosine-speci?c phosphatase, which is newly discovered to be an important regulator in inflammatory and autoimmune diseases. It has been proved that TCPTP can inhibit inflammatory and immune reactions by reducing the expression of the proinflammatory cytokine TNF-α and suppressing MAPK, NF-κB and JAK/STAT pathways. It may also decrease pancreatic β-cell apoptosis and improve insulin sensitivity in diabetes. Based on these facts, we hypothesize that upregulation of TCPTP may help to reduce the periodontium destruction caused by excessive inflammatory response and hyperglycemia. If proved to be true, this hypothesis will provide a new promising approach for diabetic patients with periodontitis. | |||
TO cite this article:WANG Qi,LI Hao,XIA Sisi, et al. PTPN2, a potential theraputic target for diabetic patients withe periodontitis[OL].[15 May 2016] http://en.paper.edu.cn/en_releasepaper/content/4690668 |
9. A novel intragenic microdeletion in RUNX2 in a Chinese family with cleidocranial dysplasia | |||
ZHANG Tingting,SUN Yingchun,LI Xiaomeng,ZHOU Hui,ZHOU Jun,GAO Ping | |||
Clinical Medicine 14 May 2016 | |||
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Abstract:Objective: Cleidocranial dysplasia (CCD) is a rare autosomal dominant skeletal dysplasia characterized by cranial, clavicular, and dental anomalies. Aberrations in the RUNX2 gene, which is considered to be responsible for CCD, were investigated in a Chinese family with CCD in this study. Methods: Genomic DNA was isolated from the blood samples of all 11 participants, including 3 patients in this family. Mutation analysis of RUNX2 was performed using amplified polymerase chain reaction and direct sequencing. To determine the copy number of the exons of RUNX2, real-time quantitative PCR was performed for all 3 patients and the 8 unaffected individuals. Results: A previously reported SNP (rs6921145) was found, but no causative mutation was detected in the coding regions of RUNX2 by direct sequencing analysis. Real-time quantitative PCR revealed a novel exon 4 to exon 7 intragenic deletion in RUNX2 in all 3 affected family members. Conclusion: Our findings suggest that the intragenic deletion from exon 4 to exon 7 in the RUNX2 gene is the cause of CCD in this family and most likely causes CCD by altering the protein structure of RUNX2, which then fails to regulate the transcription of RUNX2-regulated genes. We therefore highlight the importance of considering deletions and duplications in patients without a causative mutation identified by DNA sequencing. | |||
TO cite this article:ZHANG Tingting,SUN Yingchun,LI Xiaomeng, et al. A novel intragenic microdeletion in RUNX2 in a Chinese family with cleidocranial dysplasia[OL].[14 May 2016] http://en.paper.edu.cn/en_releasepaper/content/4689452 |
10. Identification of the miR-30 family as a potential central player during 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in rats | |||
ZHANG Tingting,HAN Zeguang,ZHANG Ping,XU Qin,CHEN Wantao | |||
Clinical Medicine 14 May 2016 | |||
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Abstract:Objective: Constituents of tobacco can cause DNA adduct formation and are implicated in the development of oral squamous cell carcinoma (OSCC). However, there are few published studies on the mechanism(s) that underlie tobacco-associated oral carcinogenesis. It is widely known that microRNAs have an important role in the regulation of tumor generation and development. The purpose of this study was to investigate the changes of miRNAs and mRNAs expression and mutual relationship of regulation in the process of 4-nitroquinoline 1-oxide-induced carcinogenesis. Methods: 4-nitroquinoline-1-oxide (4NQO) was used to induce tongue cancer in SD rats. The differentially expressed miRNAs and mRNAs were screened using miRNA and mRNA chip technique. The differentially expressed miRNAs and mRNAs were verified by RT-PCR followed by gene ontology (GO) analysis in an attempt to build the miRNA-gene correlation network and the miRNA-go-network using bioinformatics technology. Results: The results indicated that 57 miRNAs and 474 mRNA/EST transcripts exhibited differential expression profiles between tumor and normal tongue tissues. In tumor tissue, the expression levels of the members of the rno-miR-30 family (rno-miR-30a, -30a*, -30b-5p, -30c, -30d, -30e and -30e*) were only 8% to 37% of their counterparts in the control group. Three members of the rno-miR-30 family (rno-miR-30a*, -30d, and -30e*) were the three highest degrees of miRNAs based on the miRNA-gene networks, and members rno-miR-30 b-5p, -30c, -30d, and -30e were four of the highest degrees of miRNAs uncovered by miRNA-go-network. The maximum-enrichment GOs targeted by the differentially expressed miRNA-30 family include forward locomotion, striated muscle cell development, ADP transport, and the beta-alanine catabolic process. Conclusion: These data clearly showed that decreased expression of the rno-miR-30 family may play a crucial role in carcinogenesis development, especially in metabolic processes and cell movement. Further investigations are needed to understand the role of the miR-30 family regulatory mechanism during the development of OSCC.) | |||
TO cite this article:ZHANG Tingting,HAN Zeguang,ZHANG Ping, et al. Identification of the miR-30 family as a potential central player during 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in rats[OL].[14 May 2016] http://en.paper.edu.cn/en_releasepaper/content/4689945 |
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