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	1. Comparative study of the treatment effects with FR III and Sander III appliances in children with Class III malocclusion
	ZHAO Wei,AN Xiaoli
	Clinical Medicine 02 May 2019
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	Abstract:Purpose: To evaluate and compare the skeletal and facial changes of children with mild skeletal Class III malocclusion following the treatment of the Function Regulator III appliance and the Sander III appliance. Materials and methods: The study sample consisted of 40 children presenting skeletal Class III malocclusion. The group of patients treated with the Function Regulator III appliances (FR-III) consisted of 20 subjects with a mean age of 7.615±0.9996 years. The group of patients treated with the Sander III appliances (SD-III) consisted of 20 subjects with a mean age of 7.68±1.0665 years. Lateral cephalograms were obtained immediately before initiation and after completion of the treatment. Twenty-one variables were used for the analysis of skeletal and lateral profile changes. The non-parametric test was utilized to evaluate the presence of significant changes (P < 0.05). Results: Cephalometric analysis showed that the ANB angle increased by 4.05o in the SD-III group, compared with 1.46o in the FR-III group (p < 0.0001). There was 1.93o and 5.75o increase in GoGn-SN and FMA respectively in SD-III group, and the trends in FR-III group were similar, but there was no statistical difference between the two groups(p＞0.05). Conclusion: SD-III is suitable for the maxillary deficiency of skeletal Class III malocclusion with low or average mandibular plane angle, rather than the high angle patients with apparent mandibular overgrowth. FR-III is suitable for the functional crossbite with low or average angle and the patients of mild skeletal Class III malocclusion with normal upper and lower jaws.
	TO cite this article:ZHAO Wei,AN Xiaoli. Comparative study of the treatment effects with FR III and Sander III appliances in children with Class III malocclusion[OL].[ 2 May 2019] http://en.paper.edu.cn/en_releasepaper/content/4748845


	2. Pre-existing root cementum may promote cementum-like matrix formation in vivo by human periodontal ligament cells
	Song Aimei,Cai Jun,Pan Keqing,Yang Pishan
	Clinical Medicine 13 October 2011
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	Abstract:Objective: To observe if the healthy in situ root cementum can contribute to the new cementum formation by human periodontal ligament cells (PDLCs). Methods:Root slices were made from healthy premolars.The cementum was preserved in situ in test group; while in control group , the root cementum was scaled completely. Human PDLCs were inoculated on root slices. After 7-day co-culture, 20 root slices of each group were wrapped with polytetrafluoroethylene membrane and transplanted subcutaneously into nude mice. All mice were sacrificed after eight weeks and transplanted specimens were performed for histological observation and immunohistochemistrical stain for osteopontin(OPN) and bone sialoprotein(BSP).Results: 14 of 20 specimens in the test group revealed cementum-like tissue formation on top of the old cementum and no splits were observed between them. In control group, 17 specimens showed fibrous tissue formation along the root surface and different width of splits can be seen between the new fibrous tissue and the dentin surface. Only 3 specimens demonstrated the presence of newly formed thin cementum-like tissue.The newly formed cementum-like tissue were stained positively for both OPN and BSP. Conclusions:The results showed the healthy root cementum can provide stability for the newly formed tissue and enhance the cementum-like tissue formation on top of the old cementum . It suggests that the healthy root cementum may promote the human PDLCs to differentiate towards cementoblasts and healthy root cementum should better be preserved during the periodontal regeneration procedure.
	TO cite this article:Song Aimei,Cai Jun,Pan Keqing, et al. Pre-existing root cementum may promote cementum-like matrix formation in vivo by human periodontal ligament cells[OL].[13 October 2011] http://en.paper.edu.cn/en_releasepaper/content/4445717


	3. Transglutaminase 2: A Link between Periodontal Disease and Diabetes
	Cui Cui,Mari T. Kaartinen,Liya Chen
	Clinical Medicine 08 April 2010
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	Abstract:Diabetes is a prevalent metabolic disease with serious complications. Studies have proclaimed a bidirectional relationship between diabetes and periodontitis, the latter resulting from chronic inflammation of tooth-supporting structures with links to cardiovascular disease and premature births. The enzyme transglutaminase 2 (TG2) has biologic functions in insulin secretion and response, and it has recently been demonstrated to play a role in the pathogenesis of diabetes. TG2 activity influences inflammatory reactions and also wound healing, collagen deposition and bone formation. We hypothesize that changes in TG2 activity may be linked to the progression of both diseases, and thus manipulation of this activity could provide a new therapeutic route for treating periodontal disease in diabetic patients.
	TO cite this article:Cui Cui,Mari T. Kaartinen,Liya Chen. Transglutaminase 2: A Link between Periodontal Disease and Diabetes[OL].[ 8 April 2010] http://en.paper.edu.cn/en_releasepaper/content/41689

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