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1. Study on Serum Polyunsaturated Fatty Acids Level and Their Metabolic Enzyme Expression in a rat valproate-induced autism model | |||
ZHAO Gang,GAO Jingquan,LIANG Shuang,WANG Xuelai,SUN Caihong,XIA Wei,LI Xiang,CAO Yonggang,WU Lijie | |||
Preventive Medicine and Hygienics 10 December 2014 | |||
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Abstract:To explore whether the drop in the levels of serum polyunsaturated fatty acids (PUFAs) in patients with autism is associated with their metabolic enzyme, we choose rats with their embryos exposed to sodium valproate (VPA) at the 12.5th embryonic day (E12.5) as the models for autism, and observe the serum PUFAs levels and its liver metabolic enzymes expression such as Δ5-desaturase, Δ6-desaturase and elongase (Elovl2) of VPA rats and rats in a control group on postnatal day 35 (PND35). We found that the serum PUFAs levels and its liver metabolic enzyme expression of VPA rats are significantly lower, and the manifestations are similar to the behavioral changes of autism and abnormal expressions of proteins related to apoptosis and hippocampus neuron injury. This indicates that the rats with embryos exposed to VPA at an early stage may reduce the synthesis of serum PUFAs through the down-regulation of expression of PUFAs metabolic enzyme, so that it induces nervous system injury and behavioral changes. This paper will be helpful to study and explore the causes of autism. | |||
TO cite this article:ZHAO Gang,GAO Jingquan,LIANG Shuang, et al. Study on Serum Polyunsaturated Fatty Acids Level and Their Metabolic Enzyme Expression in a rat valproate-induced autism model[OL].[10 December 2014] http://en.paper.edu.cn/en_releasepaper/content/4622840 |
2. Association of estrogen receptor alpha polymorphisms with severity and symptoms of autism spectrum disorders among Chinese Han children | |||
WANG Xuelai,LIANG Shuang,Takashi X. Fujisawa,Shota Nishitani,Akemi Tomoda,ZOU Mingyang,LI Yang,WU Lijie,Kazuyuki Shinohara | |||
Preventive Medicine and Hygienics 30 September 2014 | |||
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Abstract:Purpose: Autism spectrum disorders (ASD) are a group of neurodevelopment conditions with significant sex differences. Previous studies supported that fetal testosterone exposures might be a strong factor of ASD. As aromatization of testosterone, estrogens play a crucially important role in early nervous system development and sex differentiation through estrogen receptors in animal brain. Several reports have described that single nucleotide polymorphisms (SNPs) of estrogen receptor alpha (ESR1) are associated with psychiatric disorders such as depression and schizophrenia. However, the investigation of ESR1 effected in autism has been neglected. Therefore, we tested the hypothesis that ESR1 gene is involved in the pathogenesis of autism and clinical symptoms. Methods: Genotypes rs11155819 and rs2234693 were determined in 117 children with classic autism and 117 normal children from Chinese Han population. A case-control study was performed to explore the association between ESR1 gene variants and autism susceptibility. The Children Autism Rating Scale (CARS) and Neuropsychological development examination table for children aged 0-6 years old were used, respectively, to evaluate autism severity and the developmental level. Finally, we analyzed the association of these SNPs with specific clinical symptoms. Results: The distribution of genotypes and allele frequencies of rs11155819 and rs2234693 showed no significant differences between classic autism cases and normal healthy controls. However, individuals with rs11155819 T/T genotype showed a higher CARS score, a lower value for fine motor and adaptation ability in development quotient (DQ) (p = 0.033; p = 0.032; p = 0.045). Individuals with rs2234693 T/T genotype had lower values for social behavior in DQ (p = 0.012). Conclusion: Results suggest that ESR1 variants are relevant to autism severity and clinical symptoms in the Chinese Han population. | |||
TO cite this article:WANG Xuelai,LIANG Shuang,Takashi X. Fujisawa, et al. Association of estrogen receptor alpha polymorphisms with severity and symptoms of autism spectrum disorders among Chinese Han children[OL].[30 September 2014] http://en.paper.edu.cn/en_releasepaper/content/4611980 |
3. The Association between Forced Sexual Intercourse and Health Risk Behaviours among Chinese Urban High School Students | |||
SONG Yi,JI Chengye | |||
Preventive Medicine and Hygienics 02 May 2013 | |||
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Abstract:Objective: To determine the association between Health Risk behaviours and a history of forced sexual intercourse among Chinese urban high school students. Methods: A cross-sectional study was performed among 109,754 high school students who participated in 2005 Chinese Youth Risk Behaviour Survey. Data were analyzed for 5215 students who had experienced sex behaviour (1,483 girls, 3732 boys). Multivariate logistic regression was used to determine the demographic variables and all independent relationships. Results: Of students who had sexual intercourse, 40.9% females and 29.6% males experienced forced sex (p<0.01). When analyses controlled for demographic characteristics, for the overall sample, suicidal attempt (OR, 2.3), physical abuse (OR, 1.7), verbal abuse (OR, 1.3), more frequent use of cigarette (OR, 0.5), seldom use of cigarette (OR, 0.7), heavy use of alcohol (OR, 1.6), getting drunk (OR, 0.7), and drug use (OR, 2.4) were correlated with a history of forced sex. It also found that patterns of risk behaviours differed among female and male students who had ever experienced forced sexual intercourse. Conclusions: These results suggest forced sex is associated with many health risk behaviours and approaches to reduce the harms associated with forced sex among students in school are needed. | |||
TO cite this article:SONG Yi,JI Chengye. The Association between Forced Sexual Intercourse and Health Risk Behaviours among Chinese Urban High School Students[OL].[ 2 May 2013] http://en.paper.edu.cn/en_releasepaper/content/4541083 |
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