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	1. Characterization of Akirin in the innate immune response of the kuruma shrimp Marsupenseus japonicus
	LIU Ning,SUN Jiejie,WANG Xianwei,WANG Lei,ZHANG Hongwei,ZHAO Xiaofan,WANG Jinxing
	Aquatic Science 27 November 2015
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	Abstract:Akirin as a conserved nuclear protein functions in parallel with the NF-κB of the immune deficiency (IMD) pathway and the Toll-like receptor (TLR) pathway. In this study, the full-length cDNAs of Akirin and 14-3-3 in Marsupenaeus japonicus, named as MjAki and Mj14-3-3 were identified separately. MjAki was mainly expressed in hemocytes, heart and intestine and Mj14-3-3 was detected in all six tested tissues including hemocytes, heart, hepatopancreas, gills, stomach, and intestine. The expression of MjAki was upregulated in the hemocytes of shrimp challenged with Vibrio anguillarum and white spot syndrome virus (WSSV), Mj14-3-3 was first decreased and then increased in the shrimp challenged with V. anguillarum and no obviously change in the shrimp challenged with WSSV. The expression of some AMPs was obviously suppressed by knockdown of MjAki and Mj14-3-3 with RNA interference. The interaction of MjAki with Mj14-3-3, dorsal, relish was confirmed in vitro. We proposed that MjAki combined with Mj14-3-3, dorsal and relish, acted as an active nuclear factor of NF-κB dependent pathway in innate immunity of M. japonicus.
	TO cite this article:LIU Ning,SUN Jiejie,WANG Xianwei, et al. Characterization of Akirin in the innate immune response of the kuruma shrimp Marsupenseus japonicus[OL].[27 November 2015] http://en.paper.edu.cn/en_releasepaper/content/4664578


	2. Cloning, phylogeny and expression correlated to gonads development of Leptin genes in blunt snout bream
	ZHAO Honghao,ZENG Cong,YI Shaokui,WAN Shiming,Chen Baixiang,GAO Zexia
	Aquatic Science 14 November 2015
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	Abstract:To investigate the leptin related genes expression patterns and their possible function during the gonadal development in fish, the cDNA and genomic sequences of leptin, leptin receptor (leptinR), and leptin receptor overlapping transcript like-1 (leprotl1) were cloned and their expression levels were quantified in the different gonadal development stages of Megalobrama amblycephala. The results showed that the full length cDNA sequences of leptin, leptinR, and leprotl1were 953, 3432 and 1676 bp, coding 168, 1,082, and 131 amino acid polypeptides, and the genomic sequences were 1836 bp, 28528 bp and 5480 bp, which respectively had 3, 15 and 4 exons, respectively. The phylogenetic analysis revealed that three genes were relatively conserved in fish species. Quantitative real-time PCR results showed that the three genes were ubiquitously expressed in all examined tissues during the different gonadal development stages. The leptin and leptinR took part in the onset of puberty, especially in female M. amblycephala, by increasing the expression levels in brain during the stage I to III of ovary. The expression levels of leptin and leptinR had significant differences between male and female in HPG axis tissues (P<0.05). The leptinR had the same variation tendency with leptin, but the opposite changes of expression levels were found in leprotl1, which may resist the expression of leptinR for inhibiting the function of leptin in target organ. These findings revealed details about the possible role of these genes in regulating gonadal maturation in fish species.
	TO cite this article:ZHAO Honghao,ZENG Cong,YI Shaokui, et al. Cloning, phylogeny and expression correlated to gonads development of Leptin genes in blunt snout bream[OL].[14 November 2015] http://en.paper.edu.cn/en_releasepaper/content/4661884


	3. Proteomic analysis revealed that cellular Stress Granule pathway is disrupted by Grass carp reovirus infection
	Xu Dan,Song Lang,Wang Hao,Xu Xiaoyan,Lu Liqun
	Aquatic Science 12 March 2015
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	Abstract:Grass carp (Ctenopharyngodon idella) hemorrhagic disease, caused by grass carp reovirus (GCRV), is emerging as a serious problem in grass carp aquaculture. To better understand the molecular responses to GCRV infection, two-dimensional electrophoresis (2-DE) and matrix-assisted laser desorption/ionization tandem mass spectroscopy were performed to investigate altered proteins in C. idella kidney (CIK) cells. Differentially expressed proteins in mock infected CIK cells and GCRV-infected CIK cells were compared. Twenty-three differentially expressed spots were successfully identified (22 upregulated spots and 1 downregulated spot), which included cytoskeleton proteins, macromolecular biosynthesis-associated proteins, stress response proteins, signal transduction proteins, energy metabolism-associated proteins and ubiquitin proteasome pathway-associated proteins. Moreover, 10 of the corresponding genes of the differentially expressed proteins were quantified by real-time reverse transcription polymerase chain reaction to examine their transcriptional profiles. The T cell internal antigen 1(TIA1) and Ras-GTPase-activating SH3-domain-binding protein1(G3BP1) proteins of the cellular Stress Granule pathway from grass carp Ctenopharyngodon idella (designated as CiTIA1 and CiG3BP1) were upregulated and downregulated, respectively, during GCRV infection. The full-length cDNA of CiTIA1 was 2753 bp with an open reading frame (ORF) of 1155bp that encodes a putative 385-amino acid protein. The full-length cDNA of CiG3BP1 was 2271bp ORF of 1455bp that encodes a putative 485-amino acid protein. Phylogenetic analysis revealed that the complete ORFs of CiTIA1 and CiG3BP1 were very similar to zebrafish and well characterized mammalian homologs. The expressions of the cellular proteins CiTIA1 and CiG3BP1 response to GCRV were validated by western blotting. This study provides useful information on the proteomic and cellular stress granule pathway's responses to GCRV infection, which adds to our understanding of viral pathogenesis.
	TO cite this article:Xu Dan,Song Lang,Wang Hao, et al. Proteomic analysis revealed that cellular Stress Granule pathway is disrupted by Grass carp reovirus infection[OL].[12 March 2015] http://en.paper.edu.cn/en_releasepaper/content/4633739


	4. miR-203b: a novel regulator of MyoD expression in tilapia skeletal muscle

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