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| There are 476 papers published in subject: since this site started. | |||
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| 1. Characterization and isolation of estradiol degrading bacteria Acinetobacter sp. (7-1) Isolated from Changchun, China. | |||
| YU Jian,ZHAO yanyang,HOU yue | |||
Biology 15 December 2020
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| Show/Hide Abstract | Cite this paper︱Full-text: PDF (843K B) | |||
| Abstract:17β- Estradiol, as a major environmental estrogen, is a serious threat to human health and ecological security. The MS medium containing 0.5 mM estradiol as the sole carbon source was used to isolate a new Gram-negative bacteria from the fishing pond. This screening strain can use as the sole carbon source and energy source such as estradiol and testosterone. After 16S rRNA analysis, the bacteria belong to Acinetobacter sp with 99.71% identity. The strain was Gram-negative bacilli, Spherical, Blunt round ends, Scattered or arranged in pairs, No bud, No flagella. Size 2.126μm×0.753μm; Conditions for optimum degradation of estradiol were 27℃, 150 rpm, and substrate concentration was 1 mM/L, pH7.5 and 1% inoculum. The highest degradation rate, the degradation rate can reach 85%. The strain could grow normally in 5 μg/mL auromycin, but not in 100 μg/mL ampicillin,50 μg/mL kanamycin,10 μg/mL streptomycin. The degradation rate of 17β- estradiol was 81.4%, that of testosterone was 64.6%, that of progesterone was 44.6%, and that of 17α- ethinyl estradiol was 62.3% by high performance liquid chromatography. | |||
| TO cite this article:YU Jian,ZHAO yanyang,HOU yue. Characterization and isolation of estradiol degrading bacteria Acinetobacter sp. (7-1) Isolated from Changchun, China.[OL].[15 December 2020] http://en.paper.edu.cn/en_releasepaper/content/4753226 | |||
| 2. Tyrosine hydroxylase (TH) upstream-inhibited UPF3 regulator of nonsense transcripts homolog A (UPF3A) subnetwork for learning in human left hemisphere|Prostate via nucleus to mitochondrion to cytosol RNA binding | |||
| Xi Ruipeng,HUANG Juxiang,WANG Lin | |||
Biology 14 September 2020
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| Show/Hide Abstract | Cite this paper︱Full-text: PDF (310K B) | |||
| Abstract:High tyrosine hydroxylase (TH) upstream-inhibited UPF3 regulator of nonsense transcripts homolog A (yeast) (UPF3A) molecular subnetwork was constructed, including upstream hypothetical LOC400642 (LOC400642), retinoblastoma binding protein 6 (RBBP6), ubiquitin protein ligase E3 component n-recognin 5 (UBR5); downstream chromosome 10 open reading frame 10 (C10orf10), sulfotransferase family 1A member 2 (SULT1A2) reported relation with learning in human left hemisphere. The common biology process of TH upstream-inhibited UPF3A subnetwork was identified by DAVID, containing upstream RBBP6, upstream UBR5, downstream SULT1A2, second-core UPF3A, first-core TH as protein binding; upstream RBBP6, upstream UBR5 as ubiquitin protein transferase activity, zinc ion binding, ligase activity, cellular response to DNA damage stimulus, protein ubiquitination involved in ubiquitin dependent protein catabolic process; upstream UBR5, second-core UPF3A as RNA binding; downstream SULT1A2, first-core TH as small molecule metabolic process; The common cellular component of upstream RBBP6, upstream UBR5, second-core UPF3A, first-core TH as cytoplasm; upstream RBBP6, upstream UBR5, second-core UPF3A as nucleoplasm; upstream UBR5, second-core UPF3A, first-core TH as nucleus; downstream SULT1A2, second-core UPF3A, first-core TH as cytosol; downstream C10orf10, first-core TH as mitochondrion; The common tissue distributions as Prostate_3rd maybe exist the same pattern with human left hemisphere. We propose and mutual positively verify tyrosine hydroxylase (TH) upstream-inhibited UPF3 regulator of nonsense transcripts homolog A (yeast) (UPF3A) subnetwork for learning in human left hemisphere|Prostate via nucleus to mitochondrion to cytosol RNA binding. | |||
| TO cite this article:Xi Ruipeng,HUANG Juxiang,WANG Lin. Tyrosine hydroxylase (TH) upstream-inhibited UPF3 regulator of nonsense transcripts homolog A (UPF3A) subnetwork for learning in human left hemisphere|Prostate via nucleus to mitochondrion to cytosol RNA binding[OL].[14 September 2020] http://en.paper.edu.cn/en_releasepaper/content/4752808 | |||
| 3. Observe the difference of COVID-19 variation in different regions from the type and number of base mutations | |||
| LIU Jian-Zhong, Zheng Jeffrey | |||
| Biology 06 May 2020 | |||
| Show/Hide Abstract | Cite this paper︱Full-text: PDF (618K B) | |||
| Abstract:Collecting Covid-19 genomes from three regions: Shanghai-China, Tbilisi-Georgia and Sydney-Australia, five similar genomes are selected from each region for research in this paper. Applying ”Datum gene sequence” method proposed,our results are shown that variation is immense in Sydney-Australia region, then variation is shown in the second in Tbilisi-Georgia region and it has a minimal value in Shanghai-China region respectively. | |||
| TO cite this article:LIU Jian-Zhong, Zheng Jeffrey. Observe the difference of COVID-19 variation in different regions from the type and number of base mutations[OL].[ 6 May 2020] http://en.paper.edu.cn/en_releasepaper/content/4751960 | |||
| 4. A review: Inhibitors and activators for paraoxonase 1 | |||
| Li Yan,Tang Meiling,Chen Gang,Mu Xiaojing,Huang Haiming | |||
| Biology 23 April 2020
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| Show/Hide Abstract | Cite this paper︱Full-text: PDF (782K B) | |||
| Abstract:Paraoxonase 1 (PON1) is a calcium-dependent hydrolase with many physiological functions. The decrease of PON1 activity is related to many diseases. The research about PON1 is a hot topic, and its activators and inhibitors are expected to help in our diets and in choose of drugs. The papers about PON1 activators and inhibitors were collected and classified. The PON1 activators and inhibitors are grouped into four categories: in-vivo activators, in-vitro activators, in-vivo inhibitors and in-vitro inhibitors. For each activator or inhibitor, the activating effect or inhibiting effect along with the methods used was reviewed. Up to now, we found from literatures that there were 16 samples demonstrating activating effects on PON1 in-vivo and 5 compounds showed in-vitro activation. Of the 16 in-vivo activators there were 4 plant extracts and 12 pure components. Seven in-vivo inhibitors and 71 in-vitro inhibitors have been reported in publications. Additionally, smoking, drinking and treatment with exogenous gonadotropins induced decrease of PON1 activity. The summary of the activators and inhibitors are beneficial to reveal the structure-activity relationship, and also it provides convenience to look up the activating or inhibiting effects of the compounds on PON1 at a glance. | |||
| TO cite this article:Li Yan,Tang Meiling,Chen Gang, et al. A review: Inhibitors and activators for paraoxonase 1[OL].[23 April 2020] http://en.paper.edu.cn/en_releasepaper/content/4751765 | |||
| 5. A 69 nt segment in the 5'UTR regulates translation of FOXO3a under stress conditions | |||
| Zhang Xuyan,Zhou Kantian,Zhu Ruiyu | |||
| Biology 31 March 2020
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| Show/Hide Abstract | Cite this paper︱Full-text: PDF (1039K B) | |||
| Abstract:Fork head box O3 (FOXO3a) is a transcription factor that mediates various fundamental cellular processes, including cell cycle progression, proliferation, DNA damage and apoptosis. This study showed that th | |||