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	1. Biofilm formation and antibiotic resistance pattern of dominant Staphylococcus aureus clonal lineages in China
	SONG Minghui,LI Qiongqiong,ZHANG Yi,SONG Jinxia,SHI Chunlei,SHI Xianming
	Preventive Medicine and Hygienics 19 May 2016
	Show/Hide Abstract \| Cite this paper︱Full-text: PDF (0 B)

	Abstract:Biofilm formation usually increases antimicrobial resistance capacity of Staphylococcus aureus, which poses considerable challenges to successful eradication of staphylococcal infections. In this study, a panel of 84 different S. aureus isolates belonging to 10 dominant clonal lineages in China were characterized according to their biofilm-forming capacity, and antibiotic resistance pattern. It was shown that isolates of different clonal lineages had obvious variations in biofilm-forming capacity. Resistance to individual antibacterial agents was most frequently observed to erythromycin (72.6%) and azithromycin (72.6%). Oxacillin-resistant was found in 25 (29.8%) isolates belonging to CC239-agr I and CC5-agr II. All tested isolates were further screened for the presence of 16 resistance genes by PCR, and no significant correlation was found between clonal lineage and the distribution of resistance genes. Overall, our results indicate that biofilm producers of S. aureus have a greater likelihood to carry more antibiotic resistance genes than non-biofilm producers (p<0.01).
	TO cite this article:SONG Minghui,LI Qiongqiong,ZHANG Yi, et al. Biofilm formation and antibiotic resistance pattern of dominant Staphylococcus aureus clonal lineages in China[OL].[19 May 2016] http://en.paper.edu.cn/en_releasepaper/content/4691292

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