Authentication email has already been sent, please check your email box: and activate it as soon as possible.
You can login to My Profile and manage your email alerts.
If you haven’t received the email, please:
|
|
There are 1 papers published in subject: > since this site started. |
Results per page: |
Select Subject |
Select/Unselect all | For Selected Papers |
Saved Papers
Please enter a name for this paper to be shown in your personalized Saved Papers list
|
1. A new insight into the species barrier of Mammalian Prions obtained from structure-based conservation analysis | |||
Yaofeng Wang,Bingjie Hu,Yuan Liu,Huili Zhang,Youtao Song | |||
Biology 17 December 2007 | |||
Show/Hide Abstract | Cite this paper︱Full-text: PDF (0 B) | |||
Abstract:In the previous study done by Scott, M.R. et al, residues 184, 203 and 205 were predicted to contribute to an epitope modulating prion transmission, however, the evolutionary features of these residues were still unknown. To explore that, the functional domains (121-231) of 8 mammalian prions were examined by an informative and sensitive structural conservation analysis in this study. The results identified the three residues as highly structure-conserved but sequence-nonconserved. This suggested us the residues with these features may play an important role in modulating the transmission of prion diseases. Based on our hypothesis, residue 215 with the same structure feature was also predicted to involve in prion transmission. Subsequently, a phylogenetic tree was reconstructed. The topology of the tree can explain the mystery of species barrier occurred between the mammalian prions which cannot be deduced by simply sequence phylogenetic tree. | |||
TO cite this article:Yaofeng Wang,Bingjie Hu,Yuan Liu, et al. A new insight into the species barrier of Mammalian Prions obtained from structure-based conservation analysis[OL].[17 December 2007] http://en.paper.edu.cn/en_releasepaper/content/17036 |
Select/Unselect all | For Selected Papers |
Saved Papers
Please enter a name for this paper to be shown in your personalized Saved Papers list
|
Results per page: |
About Sciencepaper Online | Privacy Policy | Terms & Conditions | Contact Us
© 2003-2012 Sciencepaper Online. unless otherwise stated