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	1. Engineering Sinorhizobium meliloti hemoprotein to enhance nosiheptide production in Streptomyces actuosus
	Qiuyan Mo,Huanyuan Zhang,Xin Tang,Lina Zhao,Yuanda Song
	Biology 29 March 2016
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	Abstract:Oxygen deficiency is a critical limiting factor for nosiheptide production in Streptomyces actuosus during fermentation. To alleviate oxygen limitation and enhance the yield of nosiheptide, hemoprotein from Sinorhizobium meliloti (SmHb) was overexpressed in S. actuosus with overexpression of hemoglobin from Vitreoscilla (VHb) as a positive control. The successful expression of SmHb and VHb in S. actuosus was confirmed by SDS-PAGE and CO-difference spectra analysis. The results showed that S. actuosus recombinant strain with SmHb expression improved nosiheptide production by 138% compared with the wild strain (WT) under the low aeration condition, which was similar to S. actuosus mutant strain with VHb expression. Furthermore, two copies of SmHb gene were integrated in S. actuosus, which further increased the nosiheptide production by approximately 1.9-fold higher than original strain, and final concentration of nosiheptide was up to 2352 μg/mL. These results suggested that engineering of SmHb could be used as an efficient method for constructing a high nosiheptide-accumulating strain.
	TO cite this article:Qiuyan Mo,Huanyuan Zhang,Xin Tang, et al. Engineering Sinorhizobium meliloti hemoprotein to enhance nosiheptide production in Streptomyces actuosus[OL].[29 March 2016] http://en.paper.edu.cn/en_releasepaper/content/4681619


	2. The functional analysis of histone acetyltransferase MOF in tumorigenesis
	Jiaming Su,Yong Cai,Jingji Jin
	Biology 24 November 2015
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	Abstract:It has been proven that epigenetic mechanisms such as histone post-translational modification via altering the chromatin structure and heritably regulating the gene expression are involved in most cellular biological processes. Thus, abnormal regulation of epigenetics is implicated in the occurrence of various diseases, includong cancer. Human MYST1 (also known as hMOF, KAT8) is a member of the MYST (Moz-Ybf2/ Sas3-Sas2-Tip60) family of histone acetyltransferases (HATs). As a catalytic subunit, hMOF can at least form two distinct multiprotein complexes (MSL and NSL) in human cells. Both complexes can acetylate histone H4 at lysine 16 (H4K16), however, NSL complex possesses broader substrate specificity and can also acetylate histone H4 at lysine 5 and 8 (H4K5 and H4K8), suggesting the complexity of intracellular functions of hMOF. Silencing of hMOF in cells leads to genomic instability, reduced transcription of certain genes, defective DNA damage repair and early embryonic lethality. Abnormal gene expression of hMOF and its corresponding acetylation of H4K16 have been found in certain primary cancer tissues including breast cancer, medulloblastoma, ovarian cancer, renal cell carcinoma, colorectal carcinoma, gastric cancer as well as non-small cell lung cancer. In this review, we provide a brief overview of the hMOF and its corresponding histone acetylation, introduce recent research findings that link hMOF functions to tumorigenesis, and speculate on the potential role that may be relevant to tumorigenic pathways.
	TO cite this article:Jiaming Su,Yong Cai,Jingji Jin. The functional analysis of histone acetyltransferase MOF in tumorigenesis[OL].[24 November 2015] http://en.paper.edu.cn/en_releasepaper/content/4665401


	3. Characterization of different 2b of Cucumber mosaic virus based on silencing suppressor
	Li Xiying ,Zhao Zhijing,Du Zhiyou,Chen Jishuang
	Biology 08 February 2010
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	Abstract:FRad35Leu2b-CMV is a spontaneous mutant from an attenuated strain FRad352b-CMV, which differs in a single amino acid from the 2b of FRad352b-CMV. FRad35Leu2b-CMV induced high pathogenicity and high viral progeny RNAs accumulation, even can revert the PTGS of GFP in the newly-developed leaves. We further show that the FRad35Leu2b-CMV inhibits the Nicotiana benthamiana AGO1-1, AGO4-1 transcription rather than FRad352b-CMV. Then we demonstrate that the PTGS suppressor (2bLeu) of FRad35Leu2b-CMV could not only suppress local gene silencing, but also suppress systemic gene silencing through blocking systemic movement of viral siRNA. Here we consider the 2bLeu interferes with the PTGS pathway by suppressing the movement of siRNAs. Taken together, we speculate that high virulence mediated by 2bLeu is achieved through blocking systemic movement of viral siRNA, and inhibiting RdDM by down-regulating AGO4-1, AGO1-1 expression.
	TO cite this article:Li Xiying ,Zhao Zhijing,Du Zhiyou, et al. Characterization of different 2b of Cucumber mosaic virus based on silencing suppressor[OL].[ 8 February 2010] http://en.paper.edu.cn/en_releasepaper/content/40057


	4. Characterization of different 2b of Cucumber mosaic virus based on silencing suppressor
	Li Xiying,Zhao Zhijing,Du Zhiyou,Chen Xiang,Chen Jishuang
	Biology 22 December 2009
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	Abstract:Rad35Leu2b-CMV is a spontaneous mutant from an attenuated strain FRad352b-CMV, which differs in a single amino acid from the 2b of FRad352b-CMV. FRad35Leu2b-CMV induced high pathogenicity and high viral progeny RNAs accumulation, even can revert the PTGS of GFP in the newly-developed leaves. We further show that the FRad35Leu2b-CMV inhibits the Nicotiana benthamiana AGO1-1, AGO4-1 transcription rather than FRad352b-CMV. Then we demonstrate that the PTGS suppressor (2bLeu) of FRad35Leu2b-CMV could not only suppress local gene silencing, but also suppress systemic gene silencing through blocking systemic movement of viral siRNA. Here we consider the 2bLeu interferes with the PTGS pathway by suppressing the movement of siRNAs. Taken together, we speculate that high virulence mediated by 2bLeu is achieved through blocking systemic movement of viral siRNA, and inhibiting RdDM by down-regulating AGO4-1, AGO1-1 expression.
	TO cite this article:Li Xiying,Zhao Zhijing,Du Zhiyou, et al. Characterization of different 2b of Cucumber mosaic virus based on silencing suppressor[OL].[22 December 2009] http://en.paper.edu.cn/en_releasepaper/content/37897


	5. Evolutionary characterization of two Cucumber mosaic virus isolates infecting Pinellia ternata of Araceae family
	HaiYan Wang,HuaRong Zhang,ZhiYou Du,Rong Zeng,JiShuang Chen
	Biology 26 February 2009
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	Abstract:Two Cucumber mosaic virus (CMV) isolates，PHz-CMV and PGs-CMV, were obtained from naturally infected Pinellia ternata as a Chinese medicinal plant belonging to Araceae family. Phylogenetic analysis showed that the pinellia isolates formed an independent clade with high support within subgroup I. Pairwise comparison analysis showed that they had high divergence from subgroup strains of IA and IB, Remarkable Difference revealed their relationships with subgroup IA and IB. Along with their RNA3 5′UTRs analysis, it is demonstrated that they may have independent evolution. It is believed that host and geographical environment had impact on evolutional types of this virus. A novel CMV subgroup is suggested based on the discussion.
	TO cite this article:HaiYan Wang,HuaRong Zhang,ZhiYou Du, et al. Evolutionary characterization of two Cucumber mosaic virus isolates infecting Pinellia ternata of Araceae family[OL].[26 February 2009] http://en.paper.edu.cn/en_releasepaper/content/29724

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