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	1. A 110 nt fragment in the 5\'UTR of STAT2 that determines IRES activity and influences cell proliferation
	Zhou Kantian,Liao Zili,Zhu Ruiyu
	Biology 30 March 2021
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	Abstract:As a unique member of the STAT (Signal Transducer and Activator of Transcription) proteins family, STAT2 cannot recognize DNA target sites as homodimers like the others, yet it plays a critical role in type I interferon (IFN-I) signaling and many other signaling pathways. It was reported that STAT2 could help cells to cope with stress conditions by promoting antiviral responses in normal cells or drug resistance in carcinoma cells. As IRES (Internal Ribosome Entry Sites) were known to help promoting survival of cells under stress, together with the discovery that the 5\'UTR of STAT2 could form stable stem-loop secondary structures with a length of 203 nt, suggesting that there might be IRES activity. To testify this speculation, bicistronic reporter assay was designed as the main method to find out whether the 5\'-UTR of STAT2 harbors an IRES element or not. During the process, the IRES activity was confirmed, followed by the discovery that IRES active central domain was located at nt 33-142 in the 5\'UTR of STAT2. Afterwards, CRISPR/Cas9 techniques were utilized to construct a knockout cell line with the deletion of sequence between nt 65-129 in 5\'UTR. And it was discovered that knockout cells grew slightly faster than those wild type ones, which meant that the knocked-out fragment had an impact on normal cell proliferation. The exact mechanism behind this result remains to be further investigated.
	TO cite this article:Zhou Kantian,Liao Zili,Zhu Ruiyu. A 110 nt fragment in the 5\'UTR of STAT2 that determines IRES activity and influences cell proliferation[OL].[30 March 2021] http://en.paper.edu.cn/en_releasepaper/content/4754243


	2. In Silico Conserved Motif and Promoter Analysis of the MIKCc-type MADS-Box Genes in Tomato
	Chen Hongyu,Chen Xiuling,Li Jingfu,Wang Aoxue
	Biology 09 January 2013
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	Abstract:In plants, MADS-box genes have been shown to be involved in all aspects of plant development, especially in flower development in angiosperms such as Arabidopsis. To understand the diversity in regulation present in these subfamilies, we investigated 42 MIKCc-type MADS-box genes from the genome of tomato, including 7 genes that have not previously been characterized. Using these sequences, we have performed a comparative analysis of tomato MIKCc-type MADS-box genes, including the description of the protein conserved motif, promoter motif and genome localization of each member. Our results suggest that many genes have diverged in their sequences after duplication and/or speciation. They also suggest that these genes may have evolved through segmental duplication events produced by polyploidy events in the past. Overall, the comparative analysis of the tomato MIKCc-type MADS-box genes will be expected to result in significant progress in investigating the regulation mechanism of MADS-box genes in higher plants.
	TO cite this article:Chen Hongyu,Chen Xiuling,Li Jingfu, et al. In Silico Conserved Motif and Promoter Analysis of the MIKCc-type MADS-Box Genes in Tomato[OL].[ 9 January 2013] http://en.paper.edu.cn/en_releasepaper/content/4512884


	3. Detection of microRNA with low abundance in serum of schizophrenia patients
	Shi Wenting ,Du Jinglun ,Qi Yuhua ,Liang Gaofeng ,Wang Tianyu ,Li Shuchun ,Yang Ke,Xie Shiping ,Xiao Zhongdang
	Biology 25 November 2010
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	Abstract:Recent studies have revealed that aberrant expression of serum miRNA can directly reflect disease status. However, the study of serum miRNA for schizophrenia has not been reported so far. In this paper, the expression levels of serum miR-346 which is the most promising miRNAs to reflect schizophrenia status are studied. Semi-nested qRT-PCR was developed to detect miR-346 with very low abundance in serum sensitively and specifically. The results showed that the expression levels of miR-346 were significantly higher in schizophrenia patients than those in normal subjects. Compared with family schizophrenia patients, circulating miR-346 was significantly higher in sporadic schizophrenia, indicating that there is a positive correlation of circulating miRNA-346 level between schizophrenia patients with and without family history.
	TO cite this article:Shi Wenting ,Du Jinglun ,Qi Yuhua , et al. Detection of microRNA with low abundance in serum of schizophrenia patients[OL].[25 November 2010] http://en.paper.edu.cn/en_releasepaper/content/4393256


	4. Transcriptional Profiling of Class A Rice Heat Stress Transcription Factors
	Ailing Liu,Xinbo Chen,Jie Zou,Xianwen Zhang,Xiaoyun Zhou,Wenfang Wang,Liyun Chen,Xinyao Xiong
	Biology 10 February 2009
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	Abstract:Expression profiles of twelve class A rice heat shock transcription factors genes (OsHsfA) were analyzed by semi-quantitative RT-PCR. The OsHsfA genes exhibited distinctive expressions in different organs and were affected differentially under abiotic stresses. Except for OsHsfA1a and OsHsfA3, all other OsHsfA family genes were strongly up-regulated under heat treatments; the majority of OsHsfA expression responses to salt, osmotic, and cold treatment primarily occur at the late stages of stress exposure. Our investigation implied that the twelve OsHSF genes may play different roles in plant development and abiotic stress responses.
	TO cite this article:Ailing Liu,Xinbo Chen,Jie Zou, et al. Transcriptional Profiling of Class A Rice Heat Stress Transcription Factors [J].

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