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1. Intragastric Administration of Evodiamine Reduces NPY and AGRP Gene Expression in The Hypothalamus and Decreases Food Intake in Rats | |||
Jinghong Shi,Jianqun Yan,Qi Lei,Junjie Zhao,Ke Chen,Dejun Yang,Xiaolin Zhao | |||
Basic Medicine 28 January 2008 | |||
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Abstract:Evodiamine (Evo), an alkaloidal component extracted from the fruit of Evodiae fructus (Evodia rutaecarpa Benth., Rutaceae), decreases the body weight of rats through a poorly defined mechanism. The hypothalamus is responsible for controlling food intake and energy expenditure. We postulate that Evo mediates this activity by modulating feeding-related peptides in the hypothalamus. We investigated the effects of Evo on food intake, body weight and the mRNA expression of hypothalamic NPY, AGRP, Pmch, POMC, CART, and MC4R, in male rats. Evo (40 mg/kg or 4 mg/kg) was intragastrically administrated for 25 days, and the food intake and body weight of rats were recorded daily. Blood samples were collected for leptin radioimmunoassay (RIA). Real-Time PCR was used to analyze the mRNA expression. Our results show that intragastric administration of Evo (40 mg/kg) inhibits food intake, decreases body weight and reduces the mRNA expression of NPY and AGRP in the hypothalamus, while it increases the circulating level of leptin. Our results indicate that Evo decreases food intake, and therefore body weight, partly by down-regulating NPY and AGRP mRNA expression in the hypothalamus. | |||
TO cite this article:Jinghong Shi,Jianqun Yan,Qi Lei, et al. Intragastric Administration of Evodiamine Reduces NPY and AGRP Gene Expression in The Hypothalamus and Decreases Food Intake in Rats[OL].[28 January 2008] http://en.paper.edu.cn/en_releasepaper/content/18417 |
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