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1. Interleukin-6 Regulates Voltage-Gated Sodium channels in a Time- and Dose-Dependent Manner in Rat Cortical Neurons | |||
SHENG Jiangtao,GAO fenfei,CHEN Weiqiang,DENG Lijuan,GUO Jingfang,WANG Gefei,DAI Jianping,HUANG Zhengyi,SHI Ganggang,LI Kangsheng | |||
Basic Medicine 10 January 2013 | |||
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Abstract:The cytokine interleukin-6 (IL-6) is expressed at elevated levels within the CNS in many neurological disorders and may contribute to the histopathological, pathophysiological, and cognitive deficits associated with such disorders. However, the effects of chronic IL-6 exposure on neuronal function in the CNS are largely unknown. A voltage-gated Na+ channel is essential for the excitability and electrical properties of neurons. Therefore, using patch-clamp recording we investigated the effects of chronic IL-6 exposure on voltage-gated Na+ channels. Our results showed that IL-6 suppressed Na+ currents through its receptor in a time- and dose-dependent manner, but did not alter the voltage-dependent activation and inactivation. The spike amplitude was also inhibited by IL-6 in the doses that decreased Na+ currents. The present data reveals chronic exposure to elevated levels of IL-6, such as occurs in various neurological diseases, produces inhibition in the voltage-gated Na+ channels without the alterations in single-channel characteristics. The results support the hypothesis that chronic IL-6 exposure can disrupt normal CNS function and thereby contribute to the pathophysiology associated with many neurological diseases. | |||
TO cite this article:SHENG Jiangtao,GAO fenfei,CHEN Weiqiang, et al. Interleukin-6 Regulates Voltage-Gated Sodium channels in a Time- and Dose-Dependent Manner in Rat Cortical Neurons[OL].[10 January 2013] http://en.paper.edu.cn/en_releasepaper/content/4513574 |
2. Induction of cytopathic effect and cytokines in coxsackievirus B3-infected murine astrocytes | |||
ZENG Jun,WANG Gefei,LI Weizhong,CHEN Xiaoxuan,XIN Gang,ZHANG Dangui,JIANG Zhiwu,LI Kangsheng | |||
Basic Medicine 09 January 2013 | |||
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Abstract:Coxsackievirus commonly infects children and occasionally causes severe meningitis and/or encephalitis in the newborn. The underlying mechanism(s) behind the central nervous system pathology is poorly defined. It is hypothesized that astrocytes may be involved in inflammatory response induced by CVB3 infection. Here we discuss this hypothesis in the context of CVB3 infection and associated inflammatory response in primary mouse astrocytes. CVB3 infected and replicated in astrocytes, with release of infectious virus particles. CVB3 induced cytopathic effect (CPE) and production of proinflammatory cytokines IL-1β, TNF-α, IL-6, and chemokine CXCL10 from astrocytes. These data suggest that direct astrocyte damage and cytokines induction could be a mechanism of virus-induced neuropathology. | |||
TO cite this article:ZENG Jun,WANG Gefei,LI Weizhong, et al. Induction of cytopathic effect and cytokines in coxsackievirus B3-infected murine astrocytes[OL].[ 9 January 2013] http://en.paper.edu.cn/en_releasepaper/content/4513097 |
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