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1. Occludin Deficiency with BACE1 Elevation in Cerebral Amyloid Angiopathy | |||
CHENG Xin,HE Ping,YAO Hailan,DONG Qiang,LI Rena,SHEN Yong | |||
Clinical Medicine 17 February 2014 | |||
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Abstract:Objective: A significant cause of spontaneous hemorrhages in the elderly is cerebral amyloid angiopathy (CAA) which causes degeneration of cerebral vessels, however, the mechanisms are unclear. Methods: We isolated leptomeningeal vessels from rapidly autopsied brains (average postmortem intervals 3.28 hours) with 9 cases of CAA and 10 cases of age-matched controls and used molecular, cell biology and immunohistochemical approaches to examine β-site APP cleaving enzyme 1 (BACE1) protein expression and enzymatic activities as well as tight junction molecular components in small and medium-sized arteries of the cerebral cortex and leptomeninges. Results: We not only identified in the cerebral vessels, including leptomeningeal and cortical vessels, but also found a significant elevation of both BACE1 protein levels and enzymatic activities in leptomeningeal vessels from CAA patients. Moreover, overexpression of BACE1 in endothelial cells resulted in a significant reduction of Occludin, a tight junction protein in blood vessels. Conclusion: These findings suggest that in addition to neurons, cerebral vascular cells express functional BACE1. Moreover, elevated vascular BACE1 may contribute to deficiency of Occludin in cerebral vessels, which ultimately plays a critical role in pathogenesis of CAA and its related hemorrhage. | |||
TO cite this article:CHENG Xin,HE Ping,YAO Hailan, et al. Occludin Deficiency with BACE1 Elevation in Cerebral Amyloid Angiopathy[OL].[17 February 2014] http://en.paper.edu.cn/en_releasepaper/content/4585653 |
2. Research Advances on the Genetics of Parkinson\ | |||
He Xianghua,Xi Jing,He Li,Xu Yanming | |||
Clinical Medicine 27 February 2009 | |||
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Abstract:Pakinson’s disease(PD) is a neurodegenerative disease with about 1% of the population affected. Recently, multiple genes were found to be related with Parkinson’s disease. This review aimed to analyze some causative genes about Parkinson’s disease, to summarize the function of pathogenic genes about this condition, and to review related genes that China have studied. In clusion, Parkinson’s disease is a movement disorder that until now has no effective ways to cure the disease.And more and more new genes are found to increase the risk of developing the condition. To date, there are 13 type of genes found to be associated with PD. And the mechanisms for genes underlie how to make the whole things changed still remains unknown. | |||
TO cite this article:He Xianghua,Xi Jing,He Li, et al. Research Advances on the Genetics of Parkinson\[OL].[27 February 2009] http://en.paper.edu.cn/en_releasepaper/content/29763 |
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