Select Subject

All (8831)

Agronomy (158)

Animal Husbandry,... (64)

Aquatic Science (16)

Astronomy (36)

Aviation (22)

Basic Medicine (184)

Biology (504)

Chemical Engineering (103)

Chemistry (635)

Civil and Archite... (105)

Clinical Medicine (236)

Computer Science ... (924)

Dynamic and Elect... (121)

Earth Science (119)

Economics (67)

Education (31)

Electrics, Commun... (927)

Energy Science an... (67)

Engineering and T... (15)

Environmental Sci... (140)

Food Science and ... (63)

Forestry (36)

Hydraulic Enginee... (40)

Mechanics (240)

Metallurgical Eng... (32)

Mine Engineering ... (38)

Nuclear Science a... (21)

Pharmacy (98)

Physics (920)

Preventive Medici... (37)

Psychology (20)

Security Science ... (17)

Sports Science (6)

Surveying and Map... (15)

Textile Science a... (16)

Traditional Chine... (56)

Transportation En... (57)

Select/Unselect all

For Selected Papers

Saved Papers

Please enter a name for this paper to be shown in your personalized Saved Papers list


	1. Preparation, characterization and antitumor activity of six polysaccharides isolated from natural sources
	CEN Yihong,WU Huaping,YAN Xiaorong,Qi Wenwen,GUO Hui,WANG Xiaoqian,XIAO Yuling
	Pharmacy 24 February 2016
	Show/Hide Abstract \| Cite this paper︱Full-text: PDF (0 B)

	Abstract:The carboxymethylated derivatives of six kinds of polysaccharides isolated from natural Angelica sinensis, Lentinus edodes, Ganoderma lucidum, Poria cocos, Astragalus membranaceus and Maitake were synthesized and characterized. In vitro anti-tumor activity results showed that derivatives of the six polysaccharides showed more effective anti-tumor activities than their original polysaccharides. Also, their water solubility was highly improved. Moreover, Angelica sinensis which showed the best antitumor effect were carboxymethylated with five different degree of carboxymethylation substitution in order to study the correlations between the antitumor activity, the water solubility and the degree of substitution (DS) of the polysaccharide. Experimental results showed that the water solubility of the carboxymethylated derivatives of Angelica sinensis (CASP) was highly improved with increasing of DS. However, the anti-tumor activity was not just enhanced with the increasing of water solubility. A relatively moderate DS (0.187) was found to have the best anti-tumor activities of CASP. Therefore, it can be concluded that carboxymethylation of polysaccharides can effectively enhance their water solubility and in vitro anti-tumor activity.
	TO cite this article:CEN Yihong,WU Huaping,YAN Xiaorong, et al. Preparation, characterization and antitumor activity of six polysaccharides isolated from natural sources[OL].[24 February 2016] http://en.paper.edu.cn/en_releasepaper/content/4678512


	2. Cell uptake of paclitaxel solid lipid nanoparticles modified by cell-penetrating peptides in A549 cells
	ZHANG Yinlong,LV Huixia,ZHOU Jianping,ZHANG Zhenhai
	Pharmacy 08 January 2013
	Show/Hide Abstract \| Cite this paper︱Full-text: PDF (0 B)

	Abstract:The aim of this study was to investigate the cytotoxicity of paclitaxel solid lipid nanoparticles(SLN) modified with stearic acid octaarginine (SA-R8-C6-SLN ) as well as the cellular uptake of Coumarin-6-loaded SLN modified with SA-R8 (SA-R8-C6-SLN) in human lung cancer cells, A549. SLN were prepared using a film dispersion method; and then their particle size, zeta potential, morphology, bound efficiency of SA-R8, drug loading efficiency, and in vitro release were characterized. SA-R8-PTX-SLN and SA-R8-C6-SLN were incubated with A549 cells to measure their cytotoxicity and cellular uptake, respectively. The results indicated that the cytotoxicity of SA-R8-PTX-SLN was enhanced significantly with the increasing amount of SA-R8 and the cellular uptakes of SLN increased with the incubated concentrations and the incubated time of SLN. In contrast, SA-R8-SLN could significantly enhance the cellular uptake of SLN and the cytotoxicity of PTX in A549 cells. These in vitro results suggest that SA-R8-SLN could be proposed as alternative drug delivery system
	TO cite this article:ZHANG Yinlong,LV Huixia,ZHOU Jianping, et al. Cell uptake of paclitaxel solid lipid nanoparticles modified by cell-penetrating peptides in A549 cells[OL].[ 8 January 2013] http://en.paper.edu.cn/en_releasepaper/content/4511164


	3. Octreotide-modified N-octyl-O, N-carboxymethyl chitosan micelles as potential carriers for targeted antitumor drug delivery
	Zou Aifeng ,Meirong Huo,Yong Zhang,Jianping Zhou,Xiaoqiang Yin,Chengli Yao,Qinnv Zhu
	Pharmacy 09 October 2011
	Show/Hide Abstract \| Cite this paper︱Full-text: PDF (0 B)

	Abstract:Octreotide (OCT) was recently found to have high binding affinity to the positive tumor cells of somatostatin receptors (SSTRs). In this study, octreotide-polyethene glycol-stearic acid (OCT-Phe-PEG-SA) was first successfully synthesized and used as a targeting molecule for N-octyl-O, N-carboxymethyl chitosan (OCC). Doxorubicin (DOX) was loaded into OCT-modified OCC micelles (DOX-OCC-OCT). The drug-loaded micelles obtained exhibited spherical shape, small particle sizes and negative zeta potentials. The cytotoxicity of DOX-OCC-OCT micelles against MCF-7 cells (SSTRs expressing) was found to significantly increase with the increased amount of OCT modification, while no significant difference was observed against WI-38 cells (no SSTRs expressing). Results of flow cytometry, fluorescence microscopy and confocal laser scanning microscopy confirmed DOX-OCC-OCT micelles could remarkably increase the uptake of DOX in MCF-7 cells. All the results indicated that OCC-OCT micelles may be a promising intracellular targeting carrier for efficient delivery of antitumor drugs into tumor cells.
	TO cite this article:Zou Aifeng ,Meirong Huo,Yong Zhang, et al. Octreotide-modified N-octyl-O, N-carboxymethyl chitosan micelles as potential carriers for targeted antitumor drug delivery[J].

Select/Unselect all

For Selected Papers

Saved Papers

Please enter a name for this paper to be shown in your personalized Saved Papers list

Third-level Subject

Rank

Alert Name:
Alerting to:
Authentication email will be sent to your email address in 24 hours
Frequency:
Email Message Format:	Plain text Graphical(HTML)

Complete the form below and we will recommend the selected titles to your friends on your behalf. * Indicates a required field.
Your name*:
Your email address*:
Recipient's name*:
Recipient's email address*:
(multiple recipient's names and email addresses should be separated with semicolons)
Your comments:	I thought you would find the page(s) useful.

Your name:
Your email address:
Recipient's name:
Recipient's email address:
(multiple recipient's names and email addresses should be separated with semicolons)
Your comments:	I thought you would find this page useful.

Disclaimer: This message was sent to your friend using the "Send it to a friend" facility on the Sciencepaper Online’ WWW site, http://www.paper.edu.cn/en. The Sciencepaper Online is not responsible for the content of this email, and anything said in this email does not necessarily reflect the Sciencepaper Online's views.

	Check out RSS, or use RSS reader to subscribe this item