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1. Tanshinone IIA Improved Non-alcoholic Fatty Liver Disease via A β2-AR-LKB1-AMPK Signaling Axis | |||
Zheng Xu,Li Haitao | |||
Food Science and Technology 03 February 2020 | |||
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Abstract:No therapeutic options currently exist for nonalcoholic fatty liver disease (NAFLD). Although commonly prescribed for cardiovascular diseases, Danshen (Salvia miltiorrhiza Bunge) has been used historically in folk medicines against chronic liver diseases, but its potential in NAFLD therapy remains uncertain. Here we reported that Tanshinone IIA (TAN-IIA), a principal constituent of Danshen, effectively ameliorated experimental NAFLD via transactivation of AMP-activated protein kinase. Using a mouse model, we established that tanshinone IIA effectively attenuated high-fat-diet induced obesity, hepatomegaly and liver steatosis. Mechanistically, we found that β2-adrenergic receptor (β2-AR) was down-regulated in liver tissues of obese mice. Tanshinone IIA might function as a β2-AR agonist, increase the intracellular cAMP levels, and turn on liver kinase B1 (LKB1)-AMP-activated protein kinase (AMPK)-acetyl-CoA carboxylase 2 (ACC2) signaling axis to promote fatty acid oxidation. Collectively, tanshinone IIA might merit investigation as a potential therapeutic agent for NAFLD especially in those patients with obesity. | |||
TO cite this article:Zheng Xu,Li Haitao. Tanshinone IIA Improved Non-alcoholic Fatty Liver Disease via A β2-AR-LKB1-AMPK Signaling Axis[OL].[ 3 February 2020] http://en.paper.edu.cn/en_releasepaper/content/4750630 |
2. Screening of lactobacilli with antagonistic activity against enteroinvasive Escherichia coli | |||
Wenyu Liu,Xiaoming Liu,Fengwei Tian,Qiuxiang Zhang,Gang Wang,Hao Zhang,Wei Chen | |||
Food Science and Technology 15 March 2012 | |||
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Abstract:In the present study, 339 lactic acid bacteria (LAB) strains, isolated from fermented dough, pickles, salted meat, baby feces and fermented dairy products, were screened for the antagonistic activity against enteroinvasive Escherichia coli (EIEC). Through the analysis of the inhibition zone of the lactobacilli spent culture supernatant (SCS) on EIEC growth, 22 LAB strains were selected. Using the in vitro assays of adhesion to HT-29 cell lines and tolerance to gastrointestinal conditions (acid and bile), two isolates, Lactobacillus plantarum CCFM 233 and Lactobacillus plantarum CCFM 231, were shown not only to inhibit the growth of EIEC significantly, but also to have high adhesion to HT-29 cell lines and good tolerance to low acid and high bile. Furthermore, the two strains could strongly antagonize the adhesion and invasion of EIEC to the HT-29 cell lines. This study suggests that Lactobacillus plantarum CCFM 233 and Lactobacillus plantarum CCFM 231 could be used as potential probiotics against EIEC. | |||
TO cite this article:Wenyu Liu,Xiaoming Liu,Fengwei Tian, et al. Screening of lactobacilli with antagonistic activity against enteroinvasive Escherichia coli[OL].[15 March 2012] http://en.paper.edu.cn/en_releasepaper/content/4471789 |
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