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1. Differentially expressed miRNA in hepatocellular carcinoma cells under hypoxic conditions is linked to transcription and phosphorylation | |||
SUN Haixiang,TANG Weiguo,HU Bo | |||
Clinical Medicine 16 May 2016 | |||
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Abstract:Hypoxia is a critical aspect of tumor biology and has been associated with poor prognosis and resistance to traditional therapy. In this study, we screened for differentially expressed genes and microRNAs (miRNAs) inhepatocellular carcinoma(HCC) cell line Huh7 under hypoxic conditions. Based on microarray data, we identified11,508 mRNAs and 58 miRNAs showing at least a 1.5-fold change in expressionunder hypoxic conditions. Gene ontology (GO) and pathway analysis showed that the differentially expressed genes were mainly involved in cell cycle regulation, cell division, transcription, and G-protein coupled receptor signaling pathways.By usingthe TargetScan and miRanda software packageswith the miRNA-mRNA negative expression network, differentially expressed miRNA targets were predicted. GO analysis showed that the primary function of these miRNAswas to regulatetranscription and phosphorylation.The miRNA-mRNA networksfor both transcription and phosphorylation were further analyzed. Network analysis showed that the key miRNAsin these networkswere miR-19a, miR-34a, miR-29a, mir-196a, miR-25 and miR-1207, whose potential gene targets include DNA-binding proteins, zinc finger proteins, and transcription factors. Some protein kinases, such as MAPK1, MAP3K4, and CDK18, were also shown to be presentin the network,demonstrating the importance of miRNAs in protein phosphorylation. These findings provide evidence that miRNAs play an important role in transcription and phosphorylation in the hypoxic response of HCC cells. | |||
TO cite this article:SUN Haixiang,TANG Weiguo,HU Bo. Differentially expressed miRNA in hepatocellular carcinoma cells under hypoxic conditions is linked to transcription and phosphorylation[OL].[16 May 2016] http://en.paper.edu.cn/en_releasepaper/content/4688662 |
2. FOXP3 gene polymorphism is associated with Chronic Hepatitis B in China | |||
CHEN Yanhui,ZHANG Henghui,WANG Yan,LIAO Weijia,QIN Liling,XIE Xingwang,FEI Ran,WANG Xueyan,MEI Minghui,WEI Lai,CHEN Hongsong | |||
Clinical Medicine 18 January 2012 | |||
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Abstract:Background and aims: The forkhead transcription factor Foxp3 is a key molecular which can mediate regulatory T cells immune-related inhibitory functions. Increased levels of FOXP3-positive Tregs in peripheral blood and focus of infection have been proved to be associated with a less favorable prognosis in various inflammatory diseases. It is of great interest to investigate the correlation between single nucleotide polymorphisms (SNPs) of FOXP3 gene and the susceptibility of Chronic Hepatitis B (CHB). Methods: Two SNPs rs2280883 and rs3761549 of FOXP3 gene in 344 patients with CHB and 372 matched controls were analyzed by Matrix-Assisted Laser Desorption/ Ionization Time of Flight Mass Spectrometry (MALDI-TOF). Results: At rs2280883 and rs3761549, there were no significant differences in the distribution of C and T alleles between CHB donors and healthy donors. Compared with healthy controls, patients with CHB had higher frequencies of TT genotype (74.1%) at rs2280883 or CC genotype (74.6%) at rs3761549 of FOXP3 gene. Patients who carried rs2280883 TT genotype (OR 1.1268 [95%CI 0.8097-1.5680], P<0.01) or rs3761549 CC genotype (OR 1.6291 [95%CI 1.1774-2.2541], P<0.00001) had high risk of suffering from CHB. Stratified analysis showed that rs2280883 TT/CT genotype was significantly associated with high incidence of HBeAg (P<0.01), and rs3761549 TT/CT genotype was also significantly associated with high incidence of HBeAg (P<0.01). Conclusions These results suggested that FOXP3 gene polymorphisms at rs2280883 and rs3761549 might be associated with the increased susceptibility to CHB. | |||
TO cite this article:CHEN Yanhui,ZHANG Henghui,WANG Yan, et al. FOXP3 gene polymorphism is associated with Chronic Hepatitis B in China[OL].[18 January 2012] http://en.paper.edu.cn/en_releasepaper/content/4463056 |
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