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	1. GDPD5 Immune Inflammation-Mediated Angiogenesis and Invasion Regulation Network in Human Hepatocellular Carcinoma (HCC) by Biocomputation
	XUE Shuaidong,WANG Ling,HUANG Juxiang
	Clinical Medicine 12 November 2018
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	Abstract:We data-analyzed and constructed the high-expression GDPD5 immune inflammation-mediated angiogenesis and invasion regulation network in human hepatocellular carcinoma (HCC) compared with low-expression (fold change≥2) no-tumor hepatitis/cirrhotic tissues (HBV or HCV infection) in GEO data set, by using integration of gene regulatory network inference method with gene ontology (GO). Our result showed that GDPD5 immune inflammation and multi-regulation upstream network BIRC5, BRCA1, CDKN3, EYA1, HOXD4, LEF1, PLA2G1B, PROK1, PTHLH, ROBO1, SCML2, REG3A activated GDPD5, and downstream GDPD5-activated CAD, CDC2, CDKN3, DKK1, E2F1, FOXM1, HMGB2, MAP2, MYCN, MYH6, NEK2, NR5A1, PROK1 in HCC. We proposed that GDPD5 activated network enhanced blood coagulation, chemotaxis, inflammatory response, interleukin-8 production, leukocyte migration, neutrophil chemotaxis, neutrophil mediated immunity, receptor mediated endocytosis, positive regulation of DNA repair, positive regulation of protein ubiquitination, as a result of inducing immune inflammation-mediated angiogenesis and invasion regulation in HCC. Our hypothesis was verified by GDPD5 regulation subnetwork containing angiogenesis, cell proliferation, transcription from RNA polymerase II promoter, transcription from RNA polymerase III promoter, Wnt receptor signaling pathway; also by GDPD5 negative regulation subnetwork including centriole replication, fatty acid biosynthesis, transcription, cell-cell adhesion, microtubule depolymerization in HCC, respectively.
	TO cite this article:XUE Shuaidong,WANG Ling,HUANG Juxiang. GDPD5 Immune Inflammation-Mediated Angiogenesis and Invasion Regulation Network in Human Hepatocellular Carcinoma (HCC) by Biocomputation[OL].[12 November 2018] http://en.paper.edu.cn/en_releasepaper/content/4746448


	2. Expression of different POT1 variant is Associated with Telomere Length and radiosensitivity in Colon and Gastric Adenocarcinoma cells in vitro
	Lei Han,Tian Muyou,Zhong Yahua,Zhou Fuxiang,Xie Conghua,Zhou Yunfeng,Liao Zhengkai
	Clinical Medicine 01 March 2014
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	Abstract:Protection of telomeres 1 (POT1) is a telomere-binding protein, which binds to the single-stranded DNA extensions of telomeres and regulates telomere length. Different POT1 mRNA variants were examined and compared with telomere length and radiosensitivity in Colon and Gastric Adenocarcinoma cells. POT1 production and telomere lengths were assessed in 10 human cancer cell lines by Real-time quantitative RT-PCR, respectively. POT1 mRNA levels, which were relatively stable, were significantly correlated with telomere length in gastric cancer cells and colon cancer groups excluding the HT29 with low telomerase activity (P<0.01). Meanwhile, POT1 v5 indexes were correlated with radiosensitivity in both colon cancer cells or gastric cancer cells (P<0.05). Pot1 might be a good marker for the examination of cell-specific telomere length and radiosensitivity. In this report, we identi?ed a key role for POT1 in the maintenance of telomeric single-stranded tails as well as DNA damage protective functions.
	TO cite this article:Lei Han,Tian Muyou,Zhong Yahua, et al. Expression of different POT1 variant is Associated with Telomere Length and radiosensitivity in Colon and Gastric Adenocarcinoma cells in vitro[OL].[ 1 March 2014] http://en.paper.edu.cn/en_releasepaper/content/4587832

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