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1. Design,synthesis and biological evaluation of novel asymmetric monocarbonyl analogues of curcumin (MACs ) as anti-inflammatory agents | |||
ZHANG Yali,ZOU Peng,ZHAO Chengguang,LIANG Guang,YANG Shulin | |||
Pharmacy 09 March 2013 | |||
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Abstract:In the past several years, a lot of symmetric mono-carbonyl analogues of curcumin (MACs) have been designed and synthesized in our laboratory. In the recent study, Eleven asymmetric MACs were designed and synthesized. Their bioactivities were evaluated by inhibit LPS-stimulated macrophages release proinflammation cytokines TNF-α and IL-6. The compound 1d exhibit the most inhibit activity among the test compounds. These data show that asymmetric MACs might serve as potential agents for the treatment of inflammatory diseases. | |||
TO cite this article:ZHANG Yali,ZOU Peng,ZHAO Chengguang, et al. Design,synthesis and biological evaluation of novel asymmetric monocarbonyl analogues of curcumin (MACs ) as anti-inflammatory agents[OL].[ 9 March 2013] http://en.paper.edu.cn/en_releasepaper/content/4528456 |
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