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	1. Icariin protects SH-SY5Y cells from formaldehyde-induced injury through inhibition of tau phosphorylation
	Song Yixiang,Miao Junye,Qiang Min,He Rongqiao,Wang Xuemei,Li Weiwei
	Traditional Chinese Medicine and Pharmacology 20 March 2014
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	Abstract:BACKGROUND: Formaldehyde-induced neurotoxicity is implicated in the pathology of Alzheimer's disease. Icariin, a flavonoid found in Chinese herbal medicine Epimedium, exhibits neuroprotective activity; however, whether Icariin antagonizes formaldehyde-induced nerve injury is unclear. AIMS: To investigate the neuroprotective effects of Icariin on formaldehyde-treated SH-SY5Y cells and the possible mechanisms involved. METHODS: SH-SY5Y cells were divided into control group, formaldehyde treatment group, and Icariin treatment group. Cell viability, apoptosis, and morphological changes were determined by CCK8, flow cytometry, and confocal microscopy, respectively. The phosphorylation of protein tau was examined by Western blot. RESULTS: Formaldehyde showed a half lethal dose (LD50) of 0.3 mM in SH-SY5Y cells. Icariin (1 - 10 μM) prevented formaldehyde-induced cell death in SH-SY5Y cells in a dose-dependent manner, with the optimal effect observed at 5 μM. Examination of cell morphology by confocal microscopy demonstrated that 5 μM ICA significantly attenuated formaldehyde-induced cell injury. Additionally, Icariin inhibited formaldehyde-induced cell apoptosis in SH-SY5Y cells. Results from western blot analysis showed that Icariin suppressed formaldehyde-induced tau phosphorylation at Thr181 and Ser396, while having no effect on the total tau protein level. Furthermore, Icariin reduced Tyr216 phosphorylation and increased Ser9 phosphorylation of the tau kinase GSK-3β. CONCLUTION: Icariin protects SH-SY5Y cells from formaldehyde-induced injury possibly through inhibition of GSK-3β-mediated tau phosphorylation.?????
	TO cite this article:Song Yixiang,Miao Junye,Qiang Min, et al. Icariin protects SH-SY5Y cells from formaldehyde-induced injury through inhibition of tau phosphorylation[OL].[20 March 2014] http://en.paper.edu.cn/en_releasepaper/content/4590573


	2. CDH1 gene polymorphisms and risk of gastric cancer associated with tongue coating appearance in a chinese population
	ZHAN Zhen,WU Juan,ZHANG Junfeng,YANG Yaping,TONG Shujuan,ZHANG Chunbing,LI Jin,YANG Xuewen,DONG Wei
	Traditional Chinese Medicine and Pharmacology 15 November 2011
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	Abstract:Objective: Tongue coating appearances have always thought to be related with the progress of gastric caner in Chinese medicine. The genetic polymorphisms in E-cadherin gene (CDH1) may affect invasive/metastatic development of gastric cancer by altering gene transcriptional activity of epithelial cell. The main concern of this paper was to explore the associations among CDH1 gene polymorphisms, tongue coating appearance and predisposition of gastric cancer. Methods: Four potentially functional polymorphisms (rs13689, rs1801552, rs16260 and rs17690554) of the CDH1 gene were genotyped in a case-control study of 387 incident gastric cancer cases and 392 healthy controls by polymerase chain reaction-ligation detection reaction (PCR-LDR) method and the information of tongue coating was also collected. In order to simplify the tongue diagnosis for easily understood by biomedical professionals, only two typical tongue coating color (white and yellow) and three tongue coating amount (thick, thin and none) were identified for this analysis. Results: None of the four polymorphisms or their haplotypes achieved significant difference in their distribution between gastric cancer cases and controls. Multiple logistic regression analyses revealed that gastric cancer risk was not significantly associated with the variant genotypes of the four CDH1 polymorphisms as compared with their wild-type genotypes. However, combined the analyses of tongue coating appearance, we found, interestingly, that carrying C allele of rs13689 and G allele of rs17690554 could increase the risk of gastric cancer (OR=2.576, 95%CI=1.227-5.406 for rs13689; OR=2.154, 95%CI=1.014-4.574 for rs17690554, respectively) in individuals with yellow tongue coating. Conclusions: Our results indicate, for the first time, that genetic variants at CDH1 gene may play a role in gastric cancer preposition in consideration of specific tongue appearance in China.
	TO cite this article:ZHAN Zhen,WU Juan,ZHANG Junfeng, et al. CDH1 gene polymorphisms and risk of gastric cancer associated with tongue coating appearance in a chinese population[OL].[15 November 2011] http://en.paper.edu.cn/en_releasepaper/content/4450077

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