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1. microRNA-133b regulates MMP9 and inhibits migration and invasion in human colorectal carcinoma cells | |||
Hu Gui,Chen Daojin,Li Xiaorong | |||
Basic Medicine 19 December 2012 | |||
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Abstract:Objective: To explore the effect and mechanism of microRNA-133b in the regulation of colorectal cancer cell migration and invasion. Methods: To construct eukaryotic expression vector of microRNA-133b and stable tansfection into human colorectal cancer cell SW-620; wound-healing assay and Matrigel invasion assay was performed to determine the effect of microRNA-133b on in vitro SW-620 migration and invasion; The possible target of miR-133b were predicted by a web-based computer program and verified by Dual-luciferase assay system. Results: The expression of miR-133b was dramatically greater in SW-620-133b compared with SW-620 (P<0.05); In sw-620 cells, expression of microRNA-133b significantly inhibited tumor cell migration and invasion(P<0.05); MMP9 was the candidate target of microRNA-133b and verified by Dual-luciferase assay. Conclusions: microRNA-133b suppresses tumor cell migration and invasion through modulation of the MMP9 signaling pathway. | |||
TO cite this article:Hu Gui,Chen Daojin,Li Xiaorong. microRNA-133b regulates MMP9 and inhibits migration and invasion in human colorectal carcinoma cells[OL].[19 December 2012] http://en.paper.edu.cn/en_releasepaper/content/4506084 |
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