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	1. BH3-only proteins in myocardial ischemia: poison or meal?
	Xin Hong,Bao Guangzhi,Wang Minjun,Zhu Yizhun
	Basic Medicine 10 January 2013
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	Abstract:Loss of myocardial cells via apoptosis has been characterized in ischemic heart disease. BH3-only proteins of Bcl-2 family are essential initiators of apoptosis during heart ischemia and hypoxia. Multiple BH3-only proteins, such as Bnip3, Nix, Puma, Bid and Bad, have been upregulated and shown to contribute to the cell death via apoptosis pathway during myocardial ischemia. Autophagic flux is activated in ischemic heart disease due to the short supply of nutrients. BH3-only proteins also control the initiation of autophagy which is another important pathway regulating cell survival and death. A novel BH3-only protein, beclin-1, plays a critical role in autophagy. Autophagy functions as cardioprotective pathway to overcome the stress through against apoptosis, but prolonged activation can result in cell death. Here we review the roles of BH-3 only proteins in myocardial ischemia.
	TO cite this article:Xin Hong,Bao Guangzhi,Wang Minjun, et al. BH3-only proteins in myocardial ischemia: poison or meal?[OL].[10 January 2013] http://en.paper.edu.cn/en_releasepaper/content/4513724


	2. The effects of REIC overexpression on biological phenotypes of gastric carcinoma AGS cell line
	Xu Xiaoyan,Xia Pu,Zheng Huachuan
	Basic Medicine 06 November 2011
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	Abstract:REIC is down-regulated in immortalized cell lines compared with the parental normal counterparts. It may inhibit colony formation, tumor growth, and induce the apoptosis. Here, gastric carcinoma AGS cell line transfected with REIC-expressing plasmid was subjected to the examination of phenotypes. REIC overexpression resulted in a low karyoplasmic ratio and proliferation, G1 arrest, high apoptosis, low migration, and invasion in AGS cells. These results suggest that REIC expression may be a promising objective and effective marker to predict pathobiological behaviors of gastric carcinoma.
	TO cite this article:Xu Xiaoyan,Xia Pu,Zheng Huachuan. The effects of REIC overexpression on biological phenotypes of gastric carcinoma AGS cell line[OL].[ 6 November 2011] http://en.paper.edu.cn/en_releasepaper/content/4448663


	3. Comparison of Overexpression of Cbfa1 and BMP-2 on Osteoblast/Cementoblast Related Genes Expression in NIH3T3 and Dental Follicle Cells
	pan keqing,Yan Shimei,Ge Shaohua,Li Shu,Zhao Yanhong,Yang Pishan
	Basic Medicine 01 April 2008
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	Abstract:Objectives: BMP-2, one of the most widely studied factors has shown some shortcomings as a therapeutic agent to enhance periodontal regeneration, while Cbfa1 is the essential transcription factor for bone formation and tooth morphogenesis. The aim of this study was to compare the function of Cbfa1 and BMP-2 on osteoblast/cementoblast related genes expression, so as to find which was more useful for periodontal regeneration. Materials and Methods: Cbfa1 and BMP-2 recombinant retroviral plasmids were transfected into packaging cells PT67 to produce retrovirus. Then the virus was added to infect NIH3T3 and dental follicle cells (DFCs) and chosen by G418 to gain the stably overexpressed Cbfa1 or BMP-2 cells. Real-time RT-PCR, western-blotting and mineralization assay were adopted to determine and compare the effect of overexpression of Cbfa1 and BMP-2 in NIH3T3 and DFCs. Results: We successfully obtained the cells that stably overexpressed Cbfa1 or BMP-2 by retrovirus infection. In NIH3T3, both Cbfa1 and BMP-2 induced osteoblast/cementoblast related genes expression and mineral nodules formation, but Cbfa1 increased more. In DFCs, overexpression of Cbfa1 also increased osteoblast/cementoblast related genes expression and mineral nodules formation, while overexpression of BMP-2 did not seem to effect the genes expression and mineralization. Conclusions: By retroviral gene transfer approach, overexpression of Cbfa1 seems more useful for periodontal regeneration than that of BMP-2 through enhancing osteoblast/cementoblast related genes expression in vitro.
	TO cite this article:pan keqing,Yan Shimei,Ge Shaohua, et al. Comparison of Overexpression of Cbfa1 and BMP-2 on Osteoblast/Cementoblast Related Genes Expression in NIH3T3 and Dental Follicle Cells[OL].[ 1 April 2008] http://en.paper.edu.cn/en_releasepaper/content/20004


	4. Overexpression of Cbfa1 Enhances Differentiation of Dental Follicle Cells into Cementoblasts
	pan keqing,Sun Qinfeng,Ge Shaohua,Li Shu,Wang Yan,Yang Pishan
	Basic Medicine 30 December 2007
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	Abstract:Core binding factor α1 (Cbfa1) is a runt domain transcription factor that is essential for bone formation and tooth development. It is hypothesized that forced expression of Cbfa1 in dental follicle cells (DFCs) can stimulate DFCs differentiation into cementoblast-like cells in vitro. In this study we investigated the function of Cbfa1 on DFCs by retroviral system, real-time RT-PCR, Western blot and mineralization assay. Real-time PT-PCR analysis indicated that cementoblast-related genes were expressed in DFCs, including osteopontin, type I collagen, bone sialoprotein, osteocalcin and cementum attachment protein, cementum-derived protein. Overexpression of Cbfa1 in DFCs enhanced the expression of these genes. Mineralization assay also showed that Cbfa1 increased the mineralization nodules formation. The results suggest that Cbfa1 plays an important role in the differentiation of DFCs into cementoblast-like cells by increasing the expression of cementoblast-related genes.
	TO cite this article:pan keqing,Sun Qinfeng,Ge Shaohua, et al. Overexpression of Cbfa1 Enhances Differentiation of Dental Follicle Cells into Cementoblasts [OL].[30 December 2007] http://en.paper.edu.cn/en_releasepaper/content/17600


	5. Effect of Glutamine on the Expression of grp75 in PC12 Cells under Glucose Deprivation
	Liu Wen,Liu Xiaoyu,Zhang Yan ,Yang Ling,Zuo Ji
	Basic Medicine 17 March 2006
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	Abstract:To investigate the effect of glutamine(Gln) on the expression of grp75 and the protective effect in PC12 cell line under glucose deprivation (GD), grp75 expression of PC12 cell with administration of Gln was analyzed by western blot and immunocytochemistry, and the change of mRNA level of grp75 was detected by RT-PCR. The cell viability (survival and apoptosis rate) and mitochondria function (mitochondria transmembrane potential) were also observed by MTT method and flow cytometry. The results showed that Gln could enhance the expression of grp75 at both a protein level and a mRNA level. The cell treated with Gln, its survival rate increased and apoptosis rate decreased under glucose deprivation. These data suggested that glutamine can protect cells from the injury induced by glucose deprivation through the expression of grp75.
	TO cite this article:Liu Wen,Liu Xiaoyu,Zhang Yan , et al. Effect of Glutamine on the Expression of grp75 in PC12 Cells under Glucose Deprivation[OL].[17 March 2006] http://en.paper.edu.cn/en_releasepaper/content/5761

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