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	1. 3D rotary culture system augment megakaryopoiesis and thrombopoiesis
	YANG Yiqing,Liu Cuicui,Lei Xiaohua,Zhou Jiaxi
	Basic Medicine 25 November 2015
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	Abstract:Platelets transfusion has been widely used by patients undergoing chemotherapy or radiotherapy, but the shortage of platelet supply limits the care of patients. While derivation of clinical-scale platelets in vitro would provide new source for transfusion, devices and procedures for deriving scalable platelets for clinical applications have not been established. In this study, we found that a rotary cell culture system (RCCS) can potentiate megakaryopoiesis and significantly improve the efficiency of platelet generation. Shear force, simulated microgravity and better diffusion of nutrients and oxygen from RSCCS altogether may account for the improved efficient platelet generation. The cost-effective and highly controllable strategy and methodology represent an important step toward large-scale platelet production for future biomedical and clinical applications.?
	TO cite this article:YANG Yiqing,Liu Cuicui,Lei Xiaohua, et al. 3D rotary culture system augment megakaryopoiesis and thrombopoiesis[OL].[25 November 2015] http://en.paper.edu.cn/en_releasepaper/content/4664369


	2. Inhibition of the mevalonate pathway ameliorates anoxia-induced down-regulation of FKBP12.6 and intracellular calcium handling dysfunction in H9c2 cells
	YANG Ying,LV Xue,Rong Xiqing,LAI Dongwu,FU Guosheng
	Basic Medicine 16 November 2014
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	Abstract:Statins have beneficial pleiotropic effects beyond lipid lowering on the cardiovascular system. These cardio-protective effects are mediated through inhibition of the intracellular mevalonate pathway, by decreasing isoprenoid intermediates synthesis and the subsequent post-translational modification of small GTPases, such as Ras, Rho, and Rac. Impaired intracellular calcium handling is considered an important physiopathologic mechanism responsible for cardiac dysfunction. Our study aimed at investigating the influence of mevalonate pathway, including its downstream small GTPases (Ras, RhoA, and Rac1) on anoxia-mediated alterations of calcium handling in H9c2 cardiomyocytes. Cultured H9c2 cardiomyocytes were exposed to acute anoxia after pretreatment with different drugs that specifically antagonize five key components in the mevalonate pathway, including 3-hydroxy-3-methylgutaryl-CoA reductase, farnesyl pyrophosphate synthase, Rho-kinase, Rac1 and Ras farnesyltransferase. Thereafter, we evaluated the effects of t?he mevalonate pathway on anoxia-induced cell death, expression of the sarcoplasmic reticulum calcium release channel (ryanodine receptor 2) and its regulator FK506-binding protein 12.6. Our experiments confirmed the role of prenylated proteins in regulating cardiomyocyte dysfunction, especially via RhoA- and Ras-related signaling pathways. Furthermore, our data demonstrated that inhibition of the mevalonate pathway could ameliorate anoxia-mediated calcium handling dysfunction with the up-regulated expression of FK506-binding protein 12.6 and consequently provided evidence for FK506-binding protein 12.6 as a "stabilizer" of ryanodine receptor 2.
	TO cite this article:YANG Ying,LV Xue,Rong Xiqing, et al. Inhibition of the mevalonate pathway ameliorates anoxia-induced down-regulation of FKBP12.6 and intracellular calcium handling dysfunction in H9c2 cells[OL].[16 November 2014] http://en.paper.edu.cn/en_releasepaper/content/4618949

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