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1. Xylocarpin H, a component of Xylocarpus granatum, produces antidepressant-like activities in mice | |||
YIN Xi,LI Xin,HAO Yaoguang,ZHAO Yiwen,ZHOU Jinghong,SHI Haishui | |||
Basic Medicine 26 November 2014 | |||
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Abstract:Major depression is a common psychiatric disorder worldwide that imposes a substantial health burden on society. Currently available antidepressants do not meet the clinical needs. Here, we report that Xylocarpin H, an active component of Xylocarpus granatum, has antidepressant-like effects in mouse models of depression. In mouse forced swimming- and tail suspension tests, two validated models of depression, oral administration of Xylocarpin H resulted in a dose-dependent decreased immobility duration within the dose range of 15-50 mg/kg. In addition, Xylocarpin H dose-dependently increased the time in the central zone at doses of 5-50 mg/kg in the locomotion activity test. The antidepressant-like activities of Xylocarpin H were associated with its inhibitory effects on hypothalamic-pituitary-adrenal (HPA) axis' hyperactivity in response to acute stress. Interestingly, these effective doses of Xylocarpin H did not affect locomotor- and HPA axis activities in the absence of stress. In summary, the present study, for the first time, demonstrated that Xylocarpin H exerts antidepressant-like effects in mouse behavioral models of depression, likely by inhibiting HPA axis systems. These data provide a strong basis for developing Xylocarpin H as a novel antidepressant agent for the treatment of major depression disorders. | |||
TO cite this article:YIN Xi,LI Xin,HAO Yaoguang, et al. Xylocarpin H, a component of Xylocarpus granatum, produces antidepressant-like activities in mice[OL].[26 November 2014] http://en.paper.edu.cn/en_releasepaper/content/4620567 |
2. Pretreatment of ginsenoside-Rd reduces ischemia-reperfusion injury in isolated rat hearts by increasing coronary flow | |||
SONG Chun,WANG Liping,WANG Qilong,GAO Mingtang | |||
Basic Medicine 06 January 2012 | |||
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Abstract:Objective: To evaluate the myocardial effects of ginsenoside-Rd in isolated rat hearts and to investigate the potential protective mechanism of ischemia-reperfusion injury. Methods: All rat hearts were isolated and perfused with modified Krebs-Heinseleit buffer (KHB) using the Langendorff preparation. For ischemia-reperfusion trial groups, hearts were treated with ginsenoside-Rd for 10 minutes after 20 minutes’ equilibrium, followed by 30 minutes’ global ischemia and 120 minutes’ reperfusion. For working heart trial groups, hearts were perfused with KHB containing ginsenoside-Rd for 40 minutes after 20 minutes’ equilibrium. Both of these two randomized controlled trials were performed using verapamil as positive control. Coronary flow (CF), heart rate (HR), left ventricular end diastolic pressure (LVEDP), left ventricular systolic pressure (LVSP), left ventricular developed pressure (LVDP), and rate pressure product (RPP) were collected to analyze the myocardial effects of ginsenoside-Rd. Results: Ginsenoside-Rd significantly increased the CF in both I/R trial and working heart trial (P<0.05). In I/R trial, it also helped lower the LVEDP and increase the RPP (P<0.05). However, in working heart trial, it showed no significant difference on the HR and LVDP (P>0.05).Conclusion: Pretreatment of ginsenoside-Rd of a middle dose could play a protective role in isolated rat ischemia-reperfusion hearts, by increasing the coronary flow rather than influencing cardiac functional properties previously. | |||
TO cite this article:SONG Chun,WANG Liping,WANG Qilong, et al. Pretreatment of ginsenoside-Rd reduces ischemia-reperfusion injury in isolated rat hearts by increasing coronary flow[OL].[ 6 January 2012] http://en.paper.edu.cn/en_releasepaper/content/4458840 |
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