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	1. Evaluation of Scutellaria barbata D.Don ethanol extract and its components on antitumor effects of low dose 5-fluorouracil against hepatocellular carcinoma cells
	XU Huanli,DU Guanhua
	Basic Medicine 30 December 2014
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	Abstract:Background: Some compounds derived from Chinese medicine have demonstrated prospective roles in sensitization to chemotherapy. Aim: This study aimed to investigate Scutellaria barbata D.Don ethanol extract (SBEE) and its components on antitumor effects of low dose 5-fluorouracil against hepatocellular carcinoma cells. Methods: The antitumor effects of SBEE and its components, and their combinations with 5-FU were detected by 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium/phenazine methosulfate assay, and the effects of drug combinations were evaluated using Jin's formula. Results:SBEE and luteolin could inhibit tumor growth in time and dose dependent manners. Drug combination study showed that SBEE and luteolin could synergize the antitumor effects of 5-fluorouracil at different dose ratios against HepG2 and Bel-7402 cells.Conclusion: SBEE and luteolin showed synergistic antitumor effects when combined with low dose 5-FU, and the mechanism of the synergistic effect remains to be to be studied.
	TO cite this article:XU Huanli,DU Guanhua. Evaluation of Scutellaria barbata D.Don ethanol extract and its components on antitumor effects of low dose 5-fluorouracil against hepatocellular carcinoma cells[OL].[30 December 2014] http://en.paper.edu.cn/en_releasepaper/content/4625638


	2. Hippocampal neuronal nitric oxide synthase contributes to chronic stress-induced hypothalamic-pituitary-adrenal axis hyperactivity
	ZHOU Qigang,ZHU Lijuan,CHEN Chen,LIU Mengying,SUN Weixiang,ZHU Dongya
	Basic Medicine 27 May 2011
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	Abstract:Hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis is a hallmark of major depression. Impairment of hippocampal glucocorticoid receptor (GR), a molecular believed to mediate the negative feedback of hippocampus on HPA axis, has been thought causally related to the hyperactivity of HPA axis in depression. However, the mechanisms for the impairment of hippocampal GR remain unknown. Here, we report that neuronal nitric oxide synthase (nNOS) acts as an important negative regulator of GR in adult hippocampus. More importantly, hippocampal nNOS mediates GR downregulation of stress-induced glucocorticoids, resulting in overexpression of hypothalamic corticotrophin-releasing factor (CRF), a peptide that governs HPA axis, and in glucocorticoids secretion, indicating hyperactivity of HPA axis.
	TO cite this article:ZHOU Qigang,ZHU Lijuan,CHEN Chen, et al. Hippocampal neuronal nitric oxide synthase contributes to chronic stress-induced hypothalamic-pituitary-adrenal axis hyperactivity[OL].[27 May 2011] http://en.paper.edu.cn/en_releasepaper/content/4429267


	3. Therapeutic value of antioxidants for abnormal prolongation of QT interval and the associated arrhythmias in a rabbit model of diabetes
	Zhang Yiqiang,Sun Xuelin,Zhang Ying,Wang Jingxiong,LV Yanjie,Yang Baofeng,Wang Zhiguo
	Basic Medicine 15 April 2011
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	Abstract:Abnormal QT prolongation is the major cardiac electrical disorder and a predictor of mortality in diabetic patients. Our previous studies suggest that dysfunction of delayed rectifier K+ current (IKr) is the main cause for the problem. Here we report the potential therapeutic role and mechanisms of vitamin E in the rabbit model of diabetes. The QT interval and action potential duration were considerably prolonged with frequent occurrence of ventricular tachyarrhythmias in diabetic rabbits. Administration of vitamin E corrected the abnormal QT prolongation and abolished the arrhythmic incidence. IKr was found markedly reduced resulting in slowing of cardiac repolarization thereby QT prolongation in diabetic hearts. The diabetic depression of IKr is primarily ascribed to oxidative damages to the cardiac membrane and proteins, as indicated by the overproduction of reactive oxygen species leading to severe lipid peroxidation and protein oxidation. Moreover, IKr depression is most likely due to the dysfunction of HERG K+ channel, the major subunit underlying native IKr, in response to oxidative stress, for peroxide aniongenerating system produced similar depression of HERG channels. Vitamin E restored the depressed IKr and HERG by its antioxidant actions which likely underlie its beneficial effects on diabetic QT prolongation and the associated arrhythmias. The data indicate that an antioxidant is sufficient for reversing the IKr/IHERG dysfunction and the consequent electrical disorders in diabetic hearts. Our study also conceptually simplifies the complex nature of diabetic electrical disorders to primarily oxidative stress, and should stimulate interest in antioxidants as a therapeutic strategy for diabetic QT prolongation.
	TO cite this article:Zhang Yiqiang,Sun Xuelin,Zhang Ying, et al. Therapeutic value of antioxidants for abnormal prolongation of QT interval and the associated arrhythmias in a rabbit model of diabetes[OL].[15 April 2011] http://en.paper.edu.cn/en_releasepaper/content/4421002

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