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| There are 17 papers published in subject: since this site started. | |||
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| 1. Biofilm formation of an oral symbiotic bacteria and its effect on common oral pathogens | |||
| Hui Wang,Zhanhai Yu,Zhiqiang Li,Jianye Zhou | |||
Clinical Medicine 20 October 2021
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| Show/Hide Abstract | Cite this paper︱Full-text: PDF (0 B) | |||
| Abstract:As a kind of symbiotic bacteria, Streptococcus sanguinis is widely distributed in the oral cavity, mainly including the surface of teeth, oral mucosa , and human saliva. Besides, as one of the initially colonized strains, Streptococcus sanguinis is the pioneer and key role in the development of oral biofilms, which is believed to resist pathogens and promote oral health. And the evolution of its biofilms plays an important part in both bacterial adaptations to the environment and invasion of the host. This paper discusses the early colonization mechanism of Streptococcus sanguinis and its interaction with pathogens related to caries and periodontitis, and finally, summarizes the methods of biofilm research, hoping to provide ideas for the follow-up research in this field. | |||
| TO cite this article:Hui Wang,Zhanhai Yu,Zhiqiang Li, et al. Biofilm formation of an oral symbiotic bacteria and its effect on common oral pathogens[OL].[20 October 2021] http://en.paper.edu.cn/en_releasepaper/content/4755640 | |||
| 2. The role of sclerostin and receptor activator of nuclear factor κB ligand/osteoprotegerin signalling pathways in chronic periodontitis | |||
| Wang Tiantian,Yuan Xuemin,Zhang Xingxing,LI Yue,Pang Yunqing,Wang Xuemei,Wang Jing | |||
| Clinical Medicine 20 April 2018
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| Abstract: Background: Chronic periodontitis are associated with the resorption of alveolar bone. Sclerostin participates in the process of bone resorption through the RANKL/RANK/OPG pathway. However, the mechanism of bone resorption and sclerostin expression in chronic periodontitis is unclear. In this study, the purpose was to evaluate the mechanism of action of sclerostin in human chronic periodontitis. Methods: Saliva and gingival crevicular fluid were collected from systemically healthy non-periodontitis (n=30) and chronic periodontitis subjects (n=30). The protein levels of sclerostin, RANKL and OPG in saliva and gingival crevicular fluid were detected by enzyme linked immunosorbent assay (ELISA). Results: Sclerostin levels in saliva and gingival crevicular fluid were significantly higher in the chronic periodontitis group than the non-periodontitis group (P < 0.05). The level of OPG is significantly lower but the RANKL level and the ratio of RANKL/OPG was significantly higher than that in the non-periodontitis group in saliva and gingival crevicular fluid (P < 0.05). Sclerostin levels in saliva and gingival crevicular fluid were significantly positively correlated with PD, CAL and BOP (P < 0.05). Conclusions: The results showed that sclerostin may affect bone tissue damage of chronic periodontitis through RANKL/RANK/OPG pathway. It will provide a new insight into the diagnosis and treatment of periodontitis patients. | |||
| TO cite this article:Wang Tiantian,Yuan Xuemin,Zhang Xingxing, et al. The role of sclerostin and receptor activator of nuclear factor κB ligand/osteoprotegerin signalling pathways in chronic periodontitis[OL].[20 April 2018] http://en.paper.edu.cn/en_releasepaper/content/4744647 | |||
| 3. Differentially expressed miRNA in hepatocellular carcinoma cells under hypoxic conditions is linked to transcription and phosphorylation | |||
| SUN Haixiang,TANG Weiguo,HU Bo | |||
| Clinical Medicine 16 May 2016
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| Abstract:Hypoxia is a critical aspect of tumor biology and has been associated with poor prognosis and resistance to traditional therapy. In this study, we screened for differentially expressed genes and microRNAs (miRNAs) inhepatocellular carcinoma(HCC) cell line Huh7 under hypoxic conditions. Based on microarray data, we identified11,508 mRNAs and 58 miRNAs showing at least a 1.5-fold change in expressionunder hypoxic conditions. Gene ontology (GO) and pathway analysis showed that the differentially expressed genes were mainly involved in cell cycle regulation, cell division, transcription, and G-protein coupled receptor signaling pathways.By usingthe TargetScan and miRanda software packageswith the miRNA-mRNA negative expression network, differentially expressed miRNA targets were predicted. GO analysis showed that the primary function of these miRNAswas to regulatetranscription and phosphorylation.The miRNA-mRNA networksfor both transcription and phosphorylation were further analyzed. Network analysis showed that the key miRNAsin these networkswere miR-19a, miR-34a, miR-29a, mir-196a, miR-25 and miR-1207, whose potential gene targets include DNA-binding proteins, zinc finger proteins, and transcription factors. Some protein kinases, such as MAPK1, MAP3K4, and CDK18, were also shown to be presentin the network,demonstrating the importance of miRNAs in protein phosphorylation. These findings provide evidence that miRNAs play an important role in transcription and phosphorylation in the hypoxic response of HCC cells. | |||
| TO cite this article:SUN Haixiang,TANG Weiguo,HU Bo. Differentially expressed miRNA in hepatocellular carcinoma cells under hypoxic conditions is linked to transcription and phosphorylation[OL].[16 May 2016] http://en.paper.edu.cn/en_releasepaper/content/4688662 | |||
| 4. Anti-CD3 antibody treatment ameliorates transfusion-associated graft-versus-host disease in a chemotherapy based MHC mismatched transfusion mouse model | |||
| LI Xiaofan,HU Wanyu,HUANG Qinghua,LI Qing,YANG Wen,LI Nainong,CHEN Yuanzhong | |||
| Clinical Medicine 20 March 2015
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| Abstract:Transfusion-associated graft-versus-host disease (TA-GVHD) is one of the complications of transfusion. The consequences of TA-GVHD are very serious. The mortality of TA-GVHD is 90%-100% . Recently with the increasing application of immunosuppression therapy, TA-GVHD has an increasing incident rate. Thereafter, the search for an effective treatment of TA-GVHD is of clinical value. Anti CD3 monoclonal antibody has a clinical application of treating renal transplantation rejection, graft-versus-host disease and type 1 diabetes. Here we found in a mouse model of TA-GVHD with busulfan and fludarabine chemotherapy after an MHC mismatched splenocyte and blood transfusion, treatment of anti-CD3 monoclonal antibody ameliorated TA-GVHD. The mice in anti-CD3 group had a better appearance manifesting less weight loss, healthier posture, increased activity, milder diarrhea and less skin damage. The mice with anti-CD3 treatment had lower clinical score and had a longer survival;Taken together, anti-CD3 monoclonal antibody provides new methods in treatment of TA-GVHD, Given the high mortality rate, anti-CD3 could be an effective application in treating TA-GVHD . | |||
| TO cite this article:LI Xiaofan,HU Wanyu,HUANG Qinghua, et al. Anti-CD3 antibody treatment ameliorates transfusion-associated graft-versus-host disease in a chemotherapy based MHC mismatched transfusion mouse model[OL].[20 March 2015] http://en.paper.edu.cn/en_releasepaper/content/4635622 | |||
| 5. Immunosuppressive Characteristics of Forkhead Box P3-engineered Mouse Mesenchymal Stem Cells in Vitro | |||
| Li Jiequn,Qi Haizhi,Chen Guangshun | |||
| Clinical Medicine 23 October 2014
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| Abstract:In this paper, we sought to determine whether or not MSCs transfected with Foxp3 (MSC-Foxp3) exhibited stronger immunosuppressive activity than MSC-expressing vector (MSC-Mock) alone, and, if yes, define the essential mechanisms for this to occur. Successful gene transfer of Foxp3 was confirmed by Western blot analyses and Foxp3-engineered MSCs possess both the phenotype and differentiation ability associated with MSCs. Foxp3 transduction significantly improved the immunosuppressive activity of MSCs and involved both soluble mediators and cell contact-dependent mechanisms. Foxp3 transduction significantly increased the distribution of cell surface molecule neuropilin-1(Nrp-1) and costimulatory molecule programmed death ligand 1(PD-L1) in MSCs. It also promoted the induction of CD4+CD25+Foxp3+ Tregs and the production of soluble immunomodulatory factors interleukin-10 (IL-10) and transforming growth factor β (TGF-β). The findings suggest that Foxp3-engineered MSC therapy could be a promising and attractive cell therapy approach for inducing immunosuppression or transplant tolerance.an) | |||
| TO cite this article:Li Jiequn,Qi Haizhi,Chen Guangshun. Immunosuppressive Characteristics of Forkhead Box P3-engineered Mouse Mesenchymal Stem Cells in Vitro[OL].[23 October 2014] http://en.paper.edu.cn/en_releasepaper/content/4614071 | |||
| 6. DC-SIGN and reactivation of latent HIV-1 provirus | |||
| WU Nanping,JIN Changzhong | |||
| Clinical Medicine 06 March 2014
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| Abstract:The latent HIV-1 escapes host immune responses, and is insensitive to antiretroviral therapy, which is the major barrier for eradication of the virus from infected patients. One strategy to eradicate the reservoirs of HIV-1 is to reactivate the provirus. Reactivation of latent HIV-1 requires the stimulation of several signaling pathways, including ERK and NF-κB pathways which are also involved in DC-SIGN expression. DC-SIGN is important for the primary HIV-1 infection and the further dissemination. It is unclear whether DC-SIGN expression and latent HIV-1 reactivation interact with each other in DCs and how HIV-1 infection and latency will be effected by the interaction. We hypothesize that DC-SIGN expression and HIV-1 reactivation share the ERK and NF-κB signaling pathways in DCs. In line with this hypothesis, the signals stimulating DC-SIGN expression in DCs may be hijacked by latent HIV-1, promoting the virus replication and transmission. Meanwhile, when latent HIV-1 is reactivated, DC-SIGN expression will be also up regulated to help HIV-1 diffusing and escaping attack by HAART and immune response. The mutual benefit between DC-SIGN expression and HIV-1 reactivation may bring much trouble to clearance of latent HIV-1.????? | |||
| TO cite this article:WU Nanping,JIN Changzhong. DC-SIGN and reactivation of latent HIV-1 provirus[OL].[ 6 March 2014] http://en.paper.edu.cn/en_releasepaper/content/4589068 | |||
| 7. Impact of drug-eluting stents with different coating strategies on stent thrombosis: A meta-analysis of 19 randomized trials | |||
| NIU Xiaowei,YANG Cuiling,CHEN De,YAO Yali | |||
| Clinical Medicine 17 November 2013
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| Abstract:Background Whether drug-eluting stents with biodegradable polymers (BP-DES) improve safety, especially with respect to stent thrombosis (ST) compared with permanent polymers DES (PP-DES), remains uncertainty. We aimed to compare the short- and long-term outcomes and the ST risk in patients treated with BP-DES versus PP-DES. Methods We searched Medline, Embase, Web of science, CENTRAL databases, and conference proceedings/abstracts for randomized controlled trials (RCTs) comparing BP-DES with PP-DES. The primary endpoint was to compare the risks of overall and different temporal categories definite/probable ST. Other clinical outcomes were target lesion revascularization (TLR), myocardial infarction (MI), and all-cause death in short-term (≤1 year) and long-term follow-up. The meta-analyses were performed by computing odds ratios (ORs) with 95% confidence intervals (CIs) using a random-effects model. Results 19 RCTs including 20,229 patients were analysed. Overall, BP-DES significantly decreased the risks of very late definite/probable ST (OR: 0.33; 95% CI: 0.16-0.70), and TLR in long-term follow-up (OR: 0.70; 95% CI: 0.52-0.95) compared with PP-DES. There were no significant differences between the groups regarding MI incidence and mortality during both short and long follow-up period. In strati?ed analyses, the long-term superiority of BP-DES was only maintained by using first-generation DES as the comparators. Conclusions The present meta-analysis indicated that BP-DES were more efficacious than PP-DES at reducing the risks of very late ST and long-term TLR, but it could vary by heterogeneities in the use of PP-DES comparators. Additional rigorous RCTs with longer follow-up periods are warranted to verify these very promising long-term endpoints. | |||
| TO cite this article:NIU Xiaowei,YANG Cuiling,CHEN De, et al. Impact of drug-eluting stents with different coating strategies on stent thrombosis: A meta-analysis of 19 randomized trials[J]. | |||
| 8. Foam cells derived from mononuclear cells appearing in peripheral blood may predict the occurrence of acute coronary syndrome | |||
| Duo Xu,Hanbin Cui | |||
| Clinical Medicine 23 April 2013
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| Abstract:At present, there is not a conventional method which can detect atherosclerotic plaque rupture in clinical practice. Foam cells derived from Mononuclear cells are a kind of characteristic pathological cells in plaque formation. According to pathphysiologic mechanism of formation and rupture of intravascular plaque, we infer that foam cells which do not exist in peripheral blood originally will appear in peripheral blood after plaque rupture. And between plaque rupture and the occurrence of ACS, there is certain time interval. If foam cells detected in peripheral blood in the time interval, it will strongly indicate that intravascular plaque had broken. | |||
| TO cite this article:Duo Xu,Hanbin Cui. Foam cells derived from mononuclear cells appearing in peripheral blood may predict the occurrence of acute coronary syndrome[OL].[23 April 2013] http://en.paper.edu.cn/en_releasepaper/content/4539026 | |||
| 9. Association of STAT4 gene polymorphism with increased susceptibility of rheumatoid arthritis in Northern Chinese Han Subpopulation | |||
| Zhao Yi ,Xu Liu,Xia Liu,Yin Su,Yanmei Li,Shiyao Wang,Xiaoping Zhang,Lei Zhu,Tian Wang,Quan Jiang,Xiangyuang Liu,Xiaoxia Li,Cibo Huang,Rulin Jia,Xiaolan Lu,Jianping Guo,Zhanguo Li | |||
| Clinical Medicine 10 January 2013
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| Abstract:Objective Several studies have reported that a variant of STAT4 rs7574865 is strongly associated with increased susceptibility of RA in European, Korean, and Japanese populations. However, a recent study from China showed no association between STAT4 rs7574865 polymorphism and RA susceptibility in Chinese Han subpopulation. Since the Northern Hans are known to be genetically different from the Southern Hans, the aim of this study was to investigate the association of STAT4 polymorphism with RA in a large cohort of Northern Chinese Han subpopulation. Methods Six hundred forty unrelated RA patients and 662 healthy controls were enrolled in this study. All samples were genotyped for SNP rs7574865 in STAT4 by polymerase chain reaction (PCR) and direct sequencing. The association of SNP rs7574865 with RA susceptibility was calculated and the relationship between rs7574865 polymorphism and RA subgroups stratified by clinical features was estimated. Results We confirmed a significant association of STAT4 rs7574865 polymorphism with RA susceptibility in Northern Chinese Han population. The frequency of the minor T allele in RA patients was significantly higher than in healthy controls (35.2% vs 31.1%; P=0.029, OR 1.2[95% CI 1.02-1.41]). There was also a significant difference in the distribution of the genotypes of SNP rs7574865 between RA patients and healthy controls (P=0.02). However, we did not find any associations between the genetic risk and clinical and laboratory features in different RA subgroups and healthy controls in Northern Hans with regard to age, duration of disease, gender, family history and presence of RA-related autoantibodies. Conclusion STAT4 SNP rs7574865 is significantly associated with RA susceptibility in Northern Chinese Han subpopulation. The genetic differences of Han subpopulations should be considered when genetic susceptibility for diseases is studied. | |||
| TO cite this article:Zhao Yi ,Xu Liu,Xia Liu, et al. Association of STAT4 gene polymorphism with increased susceptibility of rheumatoid arthritis in Northern Chinese Han Subpopulation[OL].[10 January 2013] http://en.paper.edu.cn/en_releasepaper/content/4514204 | |||
| 10. Comparison of Amidarone and Lidocaine in a prolonged ventricular fibrillation canine model | |||
| LIU Donglin,ZENG Qixian,MENG Xianglin,LIU Hongzhen,LI Jingsha,SU Guoying,ZHONG Jingquan,ZHANG Yun | |||
| Clinical Medicine 21 March 2012
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| Abstract:Background: Ventricular fibrillation (VF) is one of the most common reasons for sudden cardiac death. Many events may prevent paramedics from timely arrival to treat cardiac events. In the present study, we compared lidocaine and amiodarone in terms of ameliorating prolonged VF. Methods: After 12 min of untreated VF, 21 dogs received 2 min of cardiopulmonary resuscitation (CPR) followed by immediate defibrillation. When the first defibrillation failed, animals were randomly assigned to 3 groups (n=7 for every group) for rapid treatment with intravenous lidocaine (1.5 mg/kg), amiodarone (5 mg/kg) or placebo (5 ml normal saline). Prolonged QT interval was defined as the difference between basic QT interval and post-resuscitation QT interval. Aortic and right atrial pressures were monitored continuously. Coronary perfusion pressure after drug administration was calculated at mid-diastole by subtracting right atrial diastolic pressure from aortic diastolic pressure. Results: The 3 groups did not differ in survival rate, hemodynamic measurements after drug administration, or heart rate, PR interval or QRS complex (p=0.074, 0.077 and 0.415, respectively). The amiodarone and lidocaine groups differed significantly in prolonged QT interval (420.0±192.2 vs. 234.0±19.5 ms, p=0.036). One case of atypical torsades de pointes was found in the amiodarone group. Three, 5, and 3 dogs in the amiodarone, lidocaine and placebo groups, respectively, survived for more than 2 hr. Conclusions: In the prolonged VF model, amiodarone and lidocaine had a similar effect on terminating VF, hemodynamics and survival rate. Lidocaine may be safer than amiodarone in terminating refractory VF. | |||
| TO cite this article:LIU Donglin,ZENG Qixian,MENG Xianglin, et al. Comparison of Amidarone and Lidocaine in a prolonged ventricular fibrillation canine model[OL].[21 March 2012] http://en.paper.edu.cn/en_releasepaper/content/4472513 | |||
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