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	1. FOXP3 gene polymorphism is associated with Chronic Hepatitis B in China
	CHEN Yanhui,ZHANG Henghui,WANG Yan,LIAO Weijia,QIN Liling,XIE Xingwang,FEI Ran,WANG Xueyan,MEI Minghui,WEI Lai,CHEN Hongsong
	Clinical Medicine 18 January 2012
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	Abstract:Background and aims: The forkhead transcription factor Foxp3 is a key molecular which can mediate regulatory T cells immune-related inhibitory functions. Increased levels of FOXP3-positive Tregs in peripheral blood and focus of infection have been proved to be associated with a less favorable prognosis in various inflammatory diseases. It is of great interest to investigate the correlation between single nucleotide polymorphisms (SNPs) of FOXP3 gene and the susceptibility of Chronic Hepatitis B (CHB). Methods: Two SNPs rs2280883 and rs3761549 of FOXP3 gene in 344 patients with CHB and 372 matched controls were analyzed by Matrix-Assisted Laser Desorption/ Ionization Time of Flight Mass Spectrometry (MALDI-TOF). Results: At rs2280883 and rs3761549, there were no significant differences in the distribution of C and T alleles between CHB donors and healthy donors. Compared with healthy controls, patients with CHB had higher frequencies of TT genotype (74.1%) at rs2280883 or CC genotype (74.6%) at rs3761549 of FOXP3 gene. Patients who carried rs2280883 TT genotype (OR 1.1268 [95%CI 0.8097-1.5680], P<0.01) or rs3761549 CC genotype (OR 1.6291 [95%CI 1.1774-2.2541], P<0.00001) had high risk of suffering from CHB. Stratified analysis showed that rs2280883 TT/CT genotype was significantly associated with high incidence of HBeAg (P<0.01), and rs3761549 TT/CT genotype was also significantly associated with high incidence of HBeAg (P<0.01). Conclusions These results suggested that FOXP3 gene polymorphisms at rs2280883 and rs3761549 might be associated with the increased susceptibility to CHB.
	TO cite this article:CHEN Yanhui,ZHANG Henghui,WANG Yan, et al. FOXP3 gene polymorphism is associated with Chronic Hepatitis B in China[OL].[18 January 2012] http://en.paper.edu.cn/en_releasepaper/content/4463056


	2. An enriched environment elevates corticosteroid receptor levels in the hippocampus and restores cognitive function in a rat model of chronic cerebral hypoperfusion
	ZHANG Lei,ZHANG Junjian,SUN Huimin,ZHU Hong,LIU Hui,YANG Ying
	Clinical Medicine 19 December 2011
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	Abstract:An enriched environment (EE) is beneficial for modifying certain behaviors, particularly in tasks involving complex cognitive functions. In models of chronic cerebral hypoperfusion (CCH), the ability of an EE to stimulate cognitive recovery depends on hippocampal synaptic plasticity and brain-derived neurotrophic factor. The mechanisms that underlie this observation, however, have not been adequately studied. Corticosteroid receptors play an important role in cognitive function. Here we investigated the effects of CCH and an EE on serum corticosteroid concentrations and on levels of the mineralocorticoid receptor (MR) and the glucocorticoid receptor (GR) in the rat hippocampus. Rats were randomly divided into four treatment groups that received either permanent bilateral ligation of the common carotid arteries or sham surgery. These procedures were followed by 4 weeks of either an EE or standard housing. After the environmental treatment, the spatial learning and memory abilities of these animals were examined using the Morris water maze. In addition, the levels of MR and GR proteins in the hippocampus were determined. We found that CCH impaired the spatial cognitive function of rats and that exposure to an EE reversed these spatial cognitive deficits. CCH also reduced the amount of MR and GR proteins in the hippocampus, but an EE often restored these levels. Our results demonstrate that EE exposure restores cognitive impairments induced by CCH and up-regulates MR and GR expression. As such, MR and GR may contribute to the beneficial effects of an EE in rats with CCH.
	TO cite this article:ZHANG Lei,ZHANG Junjian,SUN Huimin, et al. An enriched environment elevates corticosteroid receptor levels in the hippocampus and restores cognitive function in a rat model of chronic cerebral hypoperfusion[J].


	3. The physiological model of functional CT imaging
	Qian Ying,Zhang Yang
	Clinical Medicine 04 January 2011
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	Abstract:The appearance of CT is a result which is combined with traditional X-ray and computer technology.It has been applied in clinical medicine for three decades years, marking the imaging technology into a new phase.With the further development of CT technology, the disadvantage of traditional CT is appeared because it can only provide structural information. Therefore, over the past ten years, the development of fast CT scanning has prompted functional CT as a technology that is diagnosed in the blood kinetics of human tissue. The technology is based on creating physiological model. At present, the physiological model of functional CT imaging is divided into compartmental models and distributed parameter models. Compartmental models include one-compartmental model and two-compartmental model and distributed parameter models include Johnson-Wilson model, ATH model and DCATH model.
	TO cite this article:Qian Ying,Zhang Yang. The physiological model of functional CT imaging[OL].[ 4 January 2011] http://en.paper.edu.cn/en_releasepaper/content/4403012


	4. In vitro pancreas duodenal homeobox-1 enhances the differentiation of pancreatic ductal epithelial cells into insulin-producing cells
	Liu Tao,Wang Chun-you,Yu Feng,Gou Shan-miao,Wu He-shui,Xiong Jiong-xin,Zhou Feng
	Clinical Medicine 08 April 2009
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	Abstract:AIM: To observe whether PDX-1 enhances the differentiation of pancreatic ductal epithelial cells into insulin-producing cells in vitro. METHODS: Rat ductal epithelial cells were transfected with recombination plasmids XlHbox8VP16. After transfection, the insulin content of secretion was detected by RIA. The insulin-producing cells were detected by Dithizon-staining. RESULTS: The production and the insulin secretion of insulin-producing cells differentiated from transfected pancreatic ductal epithelial cells were higher than the untransfected in vitro with significant difference (P<0.05). CONCLUSION: PDX-1 can promote rat pancreatic ductal epithelial cells to differentiate into insulin-producing cells obviously in vitro.
	TO cite this article:Liu Tao,Wang Chun-you,Yu Feng, et al. In vitro pancreas duodenal homeobox-1 enhances the differentiation of pancreatic ductal epithelial cells into insulin-producing cells[OL].[ 8 April 2009] http://en.paper.edu.cn/en_releasepaper/content/31194


	5. Magnetic Nanoparticle of Fe3O4 and 5-Bromotetrandrin interact synergistically to induce apoptosis by Daunorubicin in chronic myeloid leukemia cells
	Baoan Chen,Jian Cheng,Mingfang Shen,Feng Gao,Wenlin Xu,Jiahua Ding,Chong Gao,Qian Sun ,Xinchen Sun,Guohong Li,Wenji Chen ,Ningna Chen,Lijie Liu,Xiaomao Li,Xuemei Wang
	Clinical Medicine 05 February 2009
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	Abstract:Apoptosis is a common pathway that finally mediated the killing functions of anticancer drugs, which is an important cause of MDR. The aim of this study was to investigate the potential benefit of combination therapy with MNP(Fe3O4) and BrTet. Analysis of the apoptosis percentage showed that combination of DNR with either MNP(Fe3O4) or BrTet exerted a potent cytotoxic effect on K562/A02 cells, while MNP(Fe3O4) and BrTet cotreatment can synergistically enhance DNR-induced apoptosis. Importantly, we confirmed that the distinct synergism effect of that composite on reverse multidrug resistant may owe to the regulation of various proliferative and antiapoptotic gene products, including P53 and casepase-3. Thus our in vitro data strongly suggest a potential clinical application of MNP(Fe3O4) and BrTet combination on CML.
	TO cite this article:Baoan Chen,Jian Cheng,Mingfang Shen, et al. Magnetic Nanoparticle of Fe3O4 and 5-Bromotetrandrin interact synergistically to induce apoptosis by Daunorubicin in chronic myeloid leukemia cells [OL].[ 5 February 2009] http://en.paper.edu.cn/en_releasepaper/content/28446


	6. Effects of Magnetic Nanoparticle of Fe3O4 and 5Bromotetrandrin on apoptosis induced by Daunorubicin in K562/A02 Leukemic cells
	Shen Mingfang,Chen Baoan,Cheng Jian,Gao Feng,Xu Wenlin,Ding Jiahua,Gao Chong,Sun Xinchen,Li Guohong,Chen Wenji,Liu Lijie,Li Xiaomao,Wang Xuemei
	Clinical Medicine 23 January 2009
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	Abstract:The aim of this study was to investigate the potential benefit of combination therapy with Magnetic Nanoparticle of Fe3O4 and 5Bromotetrandrine on chronic leukemia. We detected the apoptosis by flow cytometry(FCM) and Wright staining. The expression of BAX and BCL-2 was measured by Western blot.The results showed that combination of DNR with either MNP(Fe3O4) or 5-BrTet exerted a potent cytotoxic effect on K562/A02 cells, while MNP(Fe3O4) and 5-BrTet cotreatment could synergistically enhance DNR-induced apoptosis. After treated with this composite, K562/A02 cells appeared typical apoptotic morphological features; the expression level of BCL-2 decreased and BAX increased markedly.It is concluded that MNP(Fe3O4) or 5-BrTet with DNR induced apoptosis in K562/ A02 cells, and when used together，they had distinct synergism .The down-regulation of BCL-2 and the up-regulation of BAX may play important roles.
	TO cite this article:Shen Mingfang,Chen Baoan,Cheng Jian, et al. Effects of Magnetic Nanoparticle of Fe3O4 and 5Bromotetrandrin on apoptosis induced by Daunorubicin in K562/A02 Leukemic cells[OL].[23 January 2009] http://en.paper.edu.cn/en_releasepaper/content/28301


	7. Transduced adult stem cells into insulin-secreting cells
	Chuan Yang,Hua Cheng,Yan Li,Dan Liu,Chuan Wang,Li Yan,Zuzhi Fu
	Clinical Medicine 12 December 2005
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	Abstract:The promising results in replacement of the beta-cell mass have been accomplished by beta-cells implanting. However, the demand for beta-cells is far greater than the supply. The transdifferentiation of stem cells into insulin-secreting cells could potentially provide a new help for beta-cell supplying. To determine whether the myoblast cell line C2C12 could be induced to transdifferentiate into insulin-secreting cells by pancreatic-duodenum homeobox-1 (PDX-1). A myoblast cell line (C2C12) was transfected by the PDX-1 constructing to overexpress PDX-1 protein and then treated with various concentrations of glucagon-like peptide-1 (GLP-1). The Expression of PDX-1 and insulin mRNA was determined by in situ hybridization and the intracellular insulin was determined by immunocytochemistry. The result shows that the PDX-1 transfected cells expressed more insulin and secreted more insulin than the vector transfected cells. We conclude that PDX-1 and GLP-1 might induce myoblasts to transdifferentiate into insulin-secreting cells.
	TO cite this article:Chuan Yang,Hua Cheng,Yan Li, et al. Transduced adult stem cells into insulin-secreting cells[OL].[12 December 2005] http://en.paper.edu.cn/en_releasepaper/content/4240

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