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	1. Protective Effect of 1, 25(OH) 2D3 on Glutamate-Induced Cytotoxicity in HT-22 Cell
	Ma Shujie,Wang Jianrong,He Jinjiang,Li Bingyan,Zhang Zengli
	Preventive Medicine and Hygienics 03 February 2017
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	Abstract:1,25(OH)2D3 deficiency may be associated with affective disorders, Parkinson's disease, Alzheimer's disease and cognitive abilities. To explore the protective effects of 1,25(OH)2D3 against glutamate-induced damage in a mouse-derived hippocampal HT-22 cells and underlying potential mechanism. The cell survival rate was determined with Cell Counting Kit-8. Cell cycle, apoptosis and reactive oxidative species (ROS) release were detected by FACs technology. Results showed that pretreatment 1,25(OH)2D3 effectively increase HT-22 cell viability up on glutamate exposure. This might be associated with the fact that 1,25(OH)2D3 significantly reduced the percentage of G0/G1 circles (G0/G1%) (p<0.01)，increased the proportion of S phase (S%) and G2/M phase (G2/M%) cells (p<0.01). Moreover, apoptosis in HT-22 cells showed the late cell apoptosis rate was decreased (p<0.05) in glutamate group incubated with 1,25(OH)2D3 (i.e. combination group) compared with the glutamate only group. There was an inverse association between the concentration of 1,25(OH)2D3 and apoptosis rate. Meanwhile, the ROS release was elevated in the combination group (p<0.05). Our study indicates that 1,25(OH)2D3 might adversely affect glutamate-induced apoptosis in the HT-22 cells，this might be owing to the fact that 1,25(OH)2D3 could increase cell proliferation and decrease late apoptosis rate. 1,25(OH)2D3 might be a promising therapeutic agent for the treatment of depression.
	TO cite this article:Ma Shujie,Wang Jianrong,He Jinjiang, et al. Protective Effect of 1, 25(OH) 2D3 on Glutamate-Induced Cytotoxicity in HT-22 Cell[OL].[ 3 February 2017] http://en.paper.edu.cn/en_releasepaper/content/4718345


	2. Preventive Effects of Green Tea on Colorectal Cancer: Meta-analysis of Prospective Cohort Study
	Fei-Fei Guo,Yulin Kong,Bing-Yan Li,Li-Qiang Qin,CL Fu,Zeng-Li Zhang
	Preventive Medicine and Hygienics 14 April 2016
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	Abstract:Green tea possibly elicits protective effects against colorectal cancer. Thus, we conducted a meta-analysis of prospective cohort studies to evaluate whether green tea has a preventive effect against colorectal cancer. A systematic literature search was conducted in PubMed. Prospective cohort studies that reported risk ratios (RRs) with 95% confidence intervals (CIs) of colorectal cancer risk of green tea consumption were included. Either a fixed-effects or a random-effects model was used to calculate pooled effects. Combined relative risk (RR) ratios for the highest vs. lowest were calculated. The combined RR derived from 10 cohort studies was 0.89 (95% CI: 0.78-1.00; p<0.001), which show that green tea consumption decreased the risk of colorectal cancer. Subgroup analysis suggested that green tea consumption significantly decreased the risk of colorectal cancer in women(RR, 0.85; 95% CI, 0.72-0.99). In summary, green tea consumption has favorable effects on colorectal cancer, especially in women. However, the result should be interpreted with caution because of the evidence of heterogeneity.
	TO cite this article:Fei-Fei Guo,Yulin Kong,Bing-Yan Li, et al. Preventive Effects of Green Tea on Colorectal Cancer: Meta-analysis of Prospective Cohort Study[OL].[14 April 2016] http://en.paper.edu.cn/en_releasepaper/content/4683985


	3. Interaction of calcium intake and osteoprotegerin gene polymorphisms on bone mass in premenarche girls
	He Guo-peng,Chen Yuming,Li Xing,Su Yixiang
	Preventive Medicine and Hygienics 19 January 2009
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	Abstract:To investigate the interaction effects of promoter region A163G,T245G and T950C polymorphisms of osteoprotegerin(OPG) gene and calcium intake on bone mass in premenarche girls. Methods: The OPG genotypes were determined by PCR-RFLP in 214 premenarche girls of Han race in Guangzhou area, and bone mineral density(BMD) at lumbar spine(L1-4), femoral neck, Ward’s triangle area(WSBMD) and total BMD, were measured by dual-energy X-rayabsorptiometry(DEXA). Current dietary calcium intakes were assessed by 3-day food record questionnaire and 3-day weighed food record method. Results: Hardy-Weinberg equilibrium was evident for OPG polymorphisms. After adjusting the confounding factors of year, height and weight, ANCOVA showed significant effect of interaction of calcium intake and T950C SNPs on WSBMD(P=0.046). WSBMD of subjects in calcium intake<500mg/d group was lower 13.0% 、23.7% than those in 500~800mg/d group and >800 mg/d group respectively among girls with TT genotype of T950C locus. However, such significance was not detected among girls with TC or CC genotype of T950C locus. Significant interaction was not observed between A163G、T245G SNPs and calcium intake on BMD. Conclusion: calcium intake and OPG T950C SNP has significant interaction on WSBMD in premenarche girls. More calcium intake would be benefit to gain higher WSBMD for girls with TT genotype of T950C locus than those with TC or CC genotype
	TO cite this article:He Guo-peng,Chen Yuming,Li Xing, et al. Interaction of calcium intake and osteoprotegerin gene polymorphisms on bone mass in premenarche girls[OL].[19 January 2009] http://en.paper.edu.cn/en_releasepaper/content/28070

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