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	1. DDX3Y Computational Catalytic Network Construction and Analysis between Left Brain of Chimpanzee and Human
	LIU Xiaoxiao,HUANG Juxiang,WANG Lin
	Biology 07 November 2018
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	Abstract:DDX3Y computational catalytic network construction and analysis of human left brain is very useful to identify novel markers and potential targets for the understanding of brain mechanism. By integration of gene regulatory network infer (GRNInfer) and the database for annotation, visualization and integrated discovery (DAVID 2010 version) we identified and constructed significant molecule DDX3Y catalytic network from 15 chimpanzee and 14 human left brain samples in the same GEO Dataset GDS2678. Our result verified DDX3Y catalytic module only in the downstream of chimpanzee left brain (AGL, PDIA2, PPID, RBBP6 activation; ENOSF1, GSTM3, RECQL, RPP14 inhibition) and downstream (DDX19A, ENPP2, RPP14, SPTLC1activation; AGL, ENOSF1, GSTM3, RECQL, HERC2P2, HERC2P3, PCSK6, PDE8A, PDIA2, PPID, RBBP6 inhibition), whereas in the upstream of human left brain (GSTM3, HSD17B6, PCSK6 activation; EGFR, ENOSF1 inhibition) and downstream (AGL, DDX19A, EGFR, HSD17B6 activation; ABCC10, ENPP2, GSTM3, HERC2P3, PCSK6, PDE8A, PDIA2, PPID, RECQL, SPTLC1 inhibition). Importantly, we datamined that DDX3Y catalytic cluster of human left brain is involved in nervous system development, ubl conjugation, response to chemical stimulus, neurogenesis, cell development and cognition, regulation of apoptosis, anatomical structure development, ATPase activity, coupled, endoplasmic reticulum, polysaccharide binding, pyrophosphatase activity, cellular localization, transport and calcium ion binding (only in human left brain terms) without Isomerase and zinc ion binding (only in chimpanzee left brain terms), the condition is vital to central nervous system development and cognition of human left brain. Our result demonstrated that common terms in both chimpanzee and human left brain include phosphoprotein, hydrolase, organelle, metabolic process, nucleic acid binding, metal-binding, acetylation, DNA binding, Golgi apparatus, identical protein binding, homeostatic process, signal transducer activity, membrane, developmental process, glycoprotein, cytoskeletal protein binding, regulation of cellular process and biosynthetic process, and these terms are more relative to development and cognition, therefore we deduced the stronger DDX3Y catalytic network in human left brain consistent with our number computation. It would be necessary of the stronger DDX3Y catalytic function to development and cognition of human left brain.
	TO cite this article:LIU Xiaoxiao,HUANG Juxiang,WANG Lin. DDX3Y Computational Catalytic Network Construction and Analysis between Left Brain of Chimpanzee and Human[OL].[ 7 November 2018] http://en.paper.edu.cn/en_releasepaper/content/4746419


	2. High EPHA4 outside-inside-out interactive neuro-induced regulation of growth through ALK-C9orf127-ARHGDIG
	ZHANG Liming,WANG Lin
	Biology 26 September 2015
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	Abstract:13 different Pearson mutual-positive-correlation EPHA4-activation molecular network was constructed from 53 overlapping of 166 GRNInfer and 70 Pearson under EPHA4 CC ≥0.25 in high human hepatocellular carcinoma (HCC) compared with low no-tumor hepatitis/cirrhotic tissues (HBV or HCV infection). Our identified EPHA4 outside-inside-out interactive molecular network showed ALK (anaplastic lymphoma receptor tyrosine kinase), C9orf127 (chromosome 9 open reading frame 127), ARHGDIG (Rho GDP dissociation inhibitor (GDI) gamma) in high HCC. EPHA4 outside-inside-out interactive terms network includes integral to plasma membrane, membrane, transmembrane receptor protein tyrosine kinase signaling pathway, nucleus, cytoplasm, mitochondrion, endoplasmic reticulum, plasma membrane, cell surface, integral to membrane, membrane fraction, cytoplasmic membrane-bound vesicle; neurogenesis, axon guidance; nervous system development, brain development, cell adhesion, cell-matrix adhesion, regulation of progression through mitotic cell cycle, regulation of growth, negative regulation of cell adhesion; nucleotide-binding, transmembrane receptor protein tyrosine kinase activity, receptor signaling protein tyrosine kinase activity, receptor activity, protein-binding, ATP-binding, transferase activity, protein-tyrosine kinase activity, ephrin receptor activity, Rho GDP-dissociation inhibitor activity, GTPase activator activity based on integrative GO, KEGG, GenMAPP, BioCarta and disease databases in high HCC. Therefore, we propose high EPHA4 outside-inside-out interactive neuro-induced regulation of growth through ALK-C9orf127-ARHGDIG in HCC.?????
	TO cite this article:ZHANG Liming,WANG Lin. High EPHA4 outside-inside-out interactive neuro-induced regulation of growth through ALK-C9orf127-ARHGDIG[OL].[26 September 2015] http://en.paper.edu.cn/en_releasepaper/content/4655855


	3. Differentiation of embryonic stem cells into hepatocytes induced by a combination of cytokines and Trichostatin A
	Zhu Xiaobo,ZHANG Dongmei,ZHANG Qian,ZHANG Jie,ZHOU Mingming
	Biology 30 October 2013
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	Abstract:In this paper，we presented a novel 3-step procedure to efficiently direct the differentiation of mouse ESCs into hepatocytes induced by combination of cytokines and sodium butyrate. Mouse ESCs were first differentiated into definitive endoderm cells by 3 days of Activin A treatment; next, presence of acid fibroblast growth factor(aFGF)and Trichostatin A (TSA)in the culture medium for 5 days, definitive endoderm cells efficiently differentiated to hepatocytes. After 10 days of further in vitro maturation, the morphological and phenotypic markers of hepatocytes were characterized using light microscopy, immunofluorescence and RT-PCR, respectively. Furthermore, these cells were tested about the functions associated with mature hepatocytes including glycogen storage, indocyanine green uptake and release,and the ratio of hepatic differentiation was determined by counting the albumin-positive cells，which showed that the ratio of hepatic differentiation was 57.38%． The ES cell differentiating method provides a new resource for hepatocytes tansplatation．
	TO cite this article:Zhu Xiaobo,ZHANG Dongmei,ZHANG Qian, et al. Differentiation of embryonic stem cells into hepatocytes induced by a combination of cytokines and Trichostatin A[OL].[30 October 2013] http://en.paper.edu.cn/en_releasepaper/content/4566643


	4. Cloning and purifying of Soluble amyloid precursor protein and its modulating MAPK signal pathway
	CHEN Keping,DOU Fei
	Biology 04 January 2013
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	Abstract:It is well known that the proteolytic processing of the amyloid precursor protein (APP) release β-amyloid (Aβ), which plays a central role in the pathogenesis of Alzheimer's disease (AD). Understanding APP processing is important for reducing Aβ levels in AD therapeutic strategy. Soluble amyloid precursor protein (sAPPa) is a proteolyte of APP cleavage by α-secretase. The significance of the cleavage and the physiological functions of sAPPα are poorly understood. In this study, we constructed the stable cell lines expressing sAPPα fusion protein and purified with tandem affinity purification (TAP) technology. We also found sAPPα could modulate the MAPK signal pathway involving in NCAM-induced neurite outgrowth, likes the full length APP.
	TO cite this article:CHEN Keping,DOU Fei. Cloning and purifying of Soluble amyloid precursor protein and its modulating MAPK signal pathway[OL].[ 4 January 2013] http://en.paper.edu.cn/en_releasepaper/content/4509550


	5. Expression and sub-cellular localization of leucine-rich repeats and immunoglobulin-like domain 1 is related to antioxidant enzymes in human ependymoma and oligodendroglioma
	YI Wei,LIU Lin,OKECHI Humphrey,CHEN Qianxue,HUANG Shulan
	Biology 27 May 2011
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	Abstract:The current study investigated correlations between the expression of leucine-rich repeats and immunoglobulin-like domain 1 (LRIG1) and antioxidant enzymes and related proteins, including manganese superoxide dismutase, glutamate cysteine ligase catalytic or regulatory subunit, thioredoxin and thioredoxin reductase, in both human ependymoma and oligodendroglioma. Results revealed that the cytoplasmic expression of LRIG1 was associated with expression of glutamate cysteine ligase catalytic subunit in the human ependymoma, while the nuclear expression of LRIG1 was associated with expression of thioredoxin reductase. In human oligodendroglioma, the cytoplasmic expression of LRIG1 was associated with expression of the glutamate cysteine ligase catalytic subunit. Both the nuclear and perinuclear expressions of LRIG1 were associated with expression of glutamate cysteine ligase regulatory subunit. These results indicated that several antioxidant enzymes and related proteins contributed to LRIG1 expression, and that these may participate in the antioxidation of the cells.
	TO cite this article:YI Wei,LIU Lin,OKECHI Humphrey, et al. Expression and sub-cellular localization of leucine-rich repeats and immunoglobulin-like domain 1 is related to antioxidant enzymes in human ependymoma and oligodendroglioma[OL].[27 May 2011] http://en.paper.edu.cn/en_releasepaper/content/4429431


	6. Stem cell and the central nervous system regeneration in planarians
	Chen Guangwen,Ma Kexue
	Biology 04 February 2010
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	Abstract:Planarians are well known for their powerful regenerative capabilities that enable them to form complete organisms from tiny body fragments. Such extraordinary regeneration and renewal of central nervous system (CNS) are depended on a population of totipotent stem cells called “Neoblasts”. Neoblasts are the only mitotically active cells in adult planarians and can differentiate into all cell types, including neurons. Therefore, planarians are ideal model systems for studying the regulation of stem cells and neurogenesis. In the last ten years, due to molecular approaches widely used in the study of planarian regeneration, the biological knowledge of this fascinating animal has been growing rapidly. In this review, we discussed the possible factors that control stem cells self-renewal and differentiation, summarized the genes specifically expressed in stem cells and the CNS, introduced the possible signaling systems in the CNS regeneration, and proposed some aspects of stem cells and neural regeneration that will need to be addressed in order to understand the fundamental principles of biology.
	TO cite this article:Chen Guangwen,Ma Kexue. Stem cell and the central nervous system regeneration in planarians[OL].[ 4 February 2010] http://en.paper.edu.cn/en_releasepaper/content/39870


	7. Using Mammospheres as a Model to Determine Protein Signatures Presented in Breast Cancer Stem Cells
	guifa li,yuxiangjiang,dongchen,wiwang,yukuncui,fukunzhao
	Biology 23 February 2009
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	Abstract:The breast cancer stem cells have been proposed to underpin many types of breast Cancer. also,mammospheres have been widely employed to study breast cancer stem cells. In current study, we have used the approaches of Proteomics to study the altered protein expression in mammospheres from the most commonly used breast cancer cell line MCF-7. we have identified 34 differentially expressed proteins in Mammospheres from parental cells. Of these 34 proteins, only seven expressed higher in Mammosheres. We find that FKBP4 and GIPC1 which is high associated with insulin-like growth factor I receptor was low expressed in mammospheres. The two proteins and their implications in breast cancer drug resistance are currently under study in our laboratory.
	TO cite this article:guifa li,yuxiangjiang,dongchen, et al. Using Mammospheres as a Model to Determine Protein Signatures Presented in Breast Cancer Stem Cells[OL].[23 February 2009] http://en.paper.edu.cn/en_releasepaper/content/29434

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