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1. The effects of collagen genes col-131, col-150, dpy-5 and col-121 on fertility and development of Caenorhabditis elegans | |||
Lu Zhaolian,Fu Ximei,Zhang Yan,Liang Hongmei,Liu Xin,Chen Gen | |||
Basic Medicine 10 October 2015 | |||
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Abstract:5-Fluorouracil (5-FU) treatment in Caenorhabditis elegans(C.elegans) leads to slow developmental rate, reduces brood size, small body size, and truncates lifespan. Using Digital Gene Expression (DGE) profiling analysis, the potential pathways and genes that could be involved in declining the embryos of C. elegans have identified. Here, when C.elegans treated by 5-FU, three down-regulated genes were identified, including col-131, col-150 and dpy-5, which belong to ECM-receptor interaction pathway and Focal adhesion and one up-regulated gene col-121 which acts in Focal adhesion. Furtherly, RNAi-mediated gene knock down method was used to examine their RNAi phenotypes. The result showed that dpy-5(RNAi) worms were short-body, dumpy, and displaying a serious defect in fertility. col-121(RNAi) worms were slender, long, and slightly altered in body development. In addition, col-121(RNAi) worms displayed abnormal body morphology. Furthermore, knocking down of col-131 has subtle side effect in C.elegans fertility; however, col-131 (RNAi) worms could rescue 5-Fu toxic effect on C.elegans on fertility and lifespan defect. Taken together, the results revealed the essential role for col-150, dpy-5 and col-121 in C.elegans fertility decline. Our data also suggested that col-131 may be an essential gene in ECM-receptor interaction pathway and Focal adhesion and regulate other cuticle collagen genes including col-150, dpy-5, and col-121. | |||
TO cite this article:Lu Zhaolian,Fu Ximei,Zhang Yan, et al. The effects of collagen genes col-131, col-150, dpy-5 and col-121 on fertility and development of Caenorhabditis elegans[OL].[10 October 2015] http://en.paper.edu.cn/en_releasepaper/content/4657315 |
2. Association Between Genetic Variants in pre-miRNA and Colorectal Cancer Risk in a Chinese Population | |||
Lv Meili,Dong Wei,Wei Yonggang,Li Lijuan,Zhang Lushun,Shu Xiaowei,Wang Li,Gao Linbo*,Zhang Lin* | |||
Basic Medicine 28 January 2013 | |||
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Abstract:Background: Single nucleotide polymorphisms (SNPs) in pre-miRNAs may alter microRNA expression levels or processing and then contribute to the susceptibility of cancer development. We hypothesized that SNPs in pre-miRNAs may be association associated with the risk of colorectal cancer (CRC). Methods: We used genotyped four common polymorphisms (i.e., rs11614913, rs3746444, rs2910164, and rs2292832) in pre-miRNAs of 353 CRC patients and 540 healthy controls to investigate the association between the SNPs and the risk of CRC using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) genotyped four common polymorphisms(rs11614913, rs3746444, rs2292832 and rs2910164) in pre-miRNAs of 353 CRC patients and 540 healthy controls to investigate the association between them and the risk of CRC assay..Results: The rs11614913 CT, TT genotypes and T allele were associated with an increased risk of CRC compared with the CC genotype and C allele (CT vs. CC: OR=7.34, 95% CI, 3.76-14.34; TT vs. CC: OR=13.66, 95% CI, 6.76-27.6; T vs. C: OR=1.99, 95% CI, 1.63-2.42, respectively). Interestingly, using the rs2910164 GG genotype as a reference, the rs2910164 GC genotype was associated with an increased risk of CRC (OR=1.49, 95% CI, 1.02-2.18), whereas the rs2910164 CC genotype was associated with a decreased risk of CRC (OR=0.58, 95% CI, 0.37-0.93). When compared with the rs2910164G allele, rs2910164 C allele was associated with a reduced risk of CRC (OR=0.80, 95% CI, 0.66-0.97, P=0.02). significantly increased CRC risk were found to be associated with CT genotype (OR=0.136, 95% CI: 0.070-0.266) and TT genotype (OR=0.073, 95% CI: 0.036-0.148) vs. CC genotype of rs11614913, CT (OR=0.166, 95% CI: 0.037-0.735,) and TT genotype (OR=0.167, 95% CI: 0.038-0.729) vs. CC genotype of rs3746444, and GC genotype (OR=0.670, 95% CI: 0.460-0.977) vs. GG genotype of rs2910164. Unfortunately, there were no statistically significant differences between cases and controls in genotype of rs2292832. When compared with the alleles, significantly increased CRC risk were found to be associated with T allele (OR=0. 530, 95% CI: 0.413-0.613) vs. C allele in rs11614913. There were no statistically significant differences between cases and controls in alleles of rs3746444, rs2292832 and rs2910164.Conculsion: These findings suggest that rs11614913 and rs2910164 polymorphisms may be associated with the etiology of CRC. | |||
TO cite this article:Lv Meili,Dong Wei,Wei Yonggang, et al. Association Between Genetic Variants in pre-miRNA and Colorectal Cancer Risk in a Chinese Population[OL].[28 January 2013] http://en.paper.edu.cn/en_releasepaper/content/4517990 |
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