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	1. Transplantation of parthenogenetic embryonic stem cells ameliorates cardiac dysfunction and remodeling after myocardial infarction
	Liu Yi,Ye Xiaoying,Mao Lina,Cheng Zhaokang,Yao Xinpeng,Jia Xiaohua,Mao Duo,Ou Lailiang,Li Zongjin,Che Yongzhe,Liu Na,Liu Lin,Kong Deling
	Basic Medicine 14 December 2012
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	Abstract:Aims: Parthenogenetic embryonic stem cells (pESCs) are derived from artificially activated oocytes without fertilization and therefore raise minimal ethical concerns and may serve as attractive candidates for regenerative medicine. We thought to investigate whether pESCs can repair myocardial infarction (MI). Methods and Results: Mice (n=89) survived coronary ligation randomly received undifferentiated pESCs, ESCs, or saline. Sham-operated mice received no treatment (n=21). After 7 days, pESCs transplantation promoted pro-angiogenic factors secretion and reduced infiltrated leukocytes. pESCs-treated hearts, superior to ESC group, showed prevented cardiac remodeling and enhanced angiogenesis in and 30 days post MI. Heart contractile function was notably improved by administration of pESCs by 30 days. Moreover, tissues regenerated from the engrafted pESCs in the infarcted myocardium were positive for cardiomyocyte, endothelial cell and smooth muscle cell markers. Furthermore, teratoma fomation appeared in ESCs-treated mice in high proportion (6/34), but surprisingly not found in pESCs-treated mice (0/30) by 30 days. Conclusions: Cardiac dysfunction and adverse ventricular remodeling post MI were attenuated by pESCs transplantation, which may represent an effective and relatively safer strategy for autologous cell therapy in females.
	TO cite this article:Liu Yi,Ye Xiaoying,Mao Lina, et al. Transplantation of parthenogenetic embryonic stem cells ameliorates cardiac dysfunction and remodeling after myocardial infarction[OL].[14 December 2012] http://en.paper.edu.cn/en_releasepaper/content/4504322


	2. Rapid biomimetic mineralization of chitosan sponges with a facile method in ethanol/water mixed solution
	Li Lihua ,Zhou Changren
	Basic Medicine 18 May 2010
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	Abstract:Mineralization of biopolymers is a hot topic and a promising method for tissue engineering. In this study, biomimetic mineralization of chitosan sponges was performed in a large quantity with a rapid and facile approach. The calcium phosphate apatite was co-precipitated as the precursor for the formation of hydroxyapatite in mixed water-ethanol solution. The component and morphology of the apatite and the nanocomposite hybrid sponges were measured with XRD, TEM, FTIR and ESEM. The mechanism of nucleation and growth of crystals were discussed as well. Results revealed that chitosan matrix improved the crystalline quality of hydroxyapatite (HAP) crystals. With elongation of mineralization time, the mineral layers on the outer surface and inner section of chitosan sponges increased. The chitosan sponge or the microenvironment around it promoted the crystallites quality of HAP phase. Furthermore, the compressive strength and modulus of the HAP-chitosan bio-composites increased to 0.55 MPa and 29.29± 1.25 MPa respectively. Such one-pot approach might be extended to the mineralization of other biopolymers and will have a very broad application in the future.
	TO cite this article:Li Lihua ,Zhou Changren . Rapid biomimetic mineralization of chitosan sponges with a facile method in ethanol/water mixed solution[OL].[18 May 2010] http://en.paper.edu.cn/en_releasepaper/content/4372783

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