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1. Discovery and identification of serum biomarkers of wilms tumor using proteomics technology | |||
JIA Zhankui,WANG Jiaxiang,YANG Jinjian,XUE Rui,ZHANG Da,WANG Guannan,MA Shengli,DUAN Zhenfeng | |||
Clinical Medicine 13 March 2012 | |||
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Abstract:Background: Wilms tumor (WT, nephroblastoma) is a cancer of the kidneys that typically occurs in children, rarely in adults. Early diagnosis of the disease is very important for its treatment and prognosis, and the aim of our study is to discover and identify potential noninvasive and convenient biomarkers for the diagnosis of this tumor. Methods: Nude mice were used to construct WT model by injecting nephroblastoma cells in their bilateral abdomen. We collected ninety four(94) serum samples from the mice for our study, including 45 WT and 49 controls. Serum proteomic profiles were analyzed using SELDI-TOF-MS. Candidate biomarkers were purified by HPLC, identified by LC-MS/MS and validated using ProteinChip immunoassays. Results: We finally retrieved two differential proteins (m/z 4509.2, 6207.9), which were identified as apolipoprotein A-II and polyubiquitin respectively. Expression of apolipoprotein A-II was higher in the WT group compared with the control group (P<0.01). In contrast, the expression of polyubiquitin was lower in the WT than in the control group. Conclusion: Apolipoprotein A-II and polyubiquitin may be used as potential biomarkers for nephroblastoma in children, and analysis of them may help us in diagnosing and treating this tumor. | |||
TO cite this article:JIA Zhankui,WANG Jiaxiang,YANG Jinjian, et al. Discovery and identification of serum biomarkers of wilms tumor using proteomics technology[OL].[13 March 2012] http://en.paper.edu.cn/en_releasepaper/content/4470377 |
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