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1. Steroid receptor coactivator-3 promotes osteosarcoma progression through upregulation of FoxM1 | |||
GENG Shuo,WANG Xiaoyu,XU Xiaoyan,ZHANG Hepeng,MA Yan,ZHANG Yunqi,LI Baoxin,BI Zhenggang,YANG Chenglin | |||
Clinical Medicine 18 December 2013 | |||
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Abstract:In this Increasing evidence suggest that the three homologous members of steroid receptor coactivator (SRC) family (SRC-1, SRC-2 and SRC-3) play key roles in enhancing cell proliferation in various human cancers, such as breast, prostate and hepatocellular carcinoma. However, the function of SRC-3 in osteosarcoma remains largely unexplored. In the current study, we found that SRC-3, but not SRC-1 and SRC-2, was dramatically up-regulated in human osteosarcoma tissues, compared with adjacent normal tissues. To explore the functions of SRC-3 in osteosarcoma, in vitro studies were performed in MG63 and U2OS cells. SRC-3 overexpression promoted osteosarcoma cells proliferation whereas knockdown of SRC-3 inhibits its proliferation. In support of these findings, we further demonstrated that SRC-3 up-regulated FoxM1 expression through co-activation of C/EBP. Together, our results show that SRC-3 drives osteosarcoma progression and imply it as a therapeutic target to abrogate osteosarcoma. | |||
TO cite this article:GENG Shuo,WANG Xiaoyu,XU Xiaoyan, et al. Steroid receptor coactivator-3 promotes osteosarcoma progression through upregulation of FoxM1[OL].[18 December 2013] http://en.paper.edu.cn/en_releasepaper/content/4571958 |
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