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1. Immunosuppressive Characteristics of Forkhead Box P3-engineered Mouse Mesenchymal Stem Cells in Vitro | |||
Li Jiequn,Qi Haizhi,Chen Guangshun | |||
Clinical Medicine 23 October 2014 | |||
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Abstract:In this paper, we sought to determine whether or not MSCs transfected with Foxp3 (MSC-Foxp3) exhibited stronger immunosuppressive activity than MSC-expressing vector (MSC-Mock) alone, and, if yes, define the essential mechanisms for this to occur. Successful gene transfer of Foxp3 was confirmed by Western blot analyses and Foxp3-engineered MSCs possess both the phenotype and differentiation ability associated with MSCs. Foxp3 transduction significantly improved the immunosuppressive activity of MSCs and involved both soluble mediators and cell contact-dependent mechanisms. Foxp3 transduction significantly increased the distribution of cell surface molecule neuropilin-1(Nrp-1) and costimulatory molecule programmed death ligand 1(PD-L1) in MSCs. It also promoted the induction of CD4+CD25+Foxp3+ Tregs and the production of soluble immunomodulatory factors interleukin-10 (IL-10) and transforming growth factor β (TGF-β). The findings suggest that Foxp3-engineered MSC therapy could be a promising and attractive cell therapy approach for inducing immunosuppression or transplant tolerance.an) | |||
TO cite this article:Li Jiequn,Qi Haizhi,Chen Guangshun. Immunosuppressive Characteristics of Forkhead Box P3-engineered Mouse Mesenchymal Stem Cells in Vitro[OL].[23 October 2014] http://en.paper.edu.cn/en_releasepaper/content/4614071 |
2. In vitro pancreas duodenal homeobox-1 enhances the differentiation of pancreatic ductal epithelial cells into insulin-producing cells | |||
Liu Tao,Wang Chun-you,Yu Feng,Gou Shan-miao,Wu He-shui,Xiong Jiong-xin,Zhou Feng | |||
Clinical Medicine 08 April 2009 | |||
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Abstract:AIM: To observe whether PDX-1 enhances the differentiation of pancreatic ductal epithelial cells into insulin-producing cells in vitro. METHODS: Rat ductal epithelial cells were transfected with recombination plasmids XlHbox8VP16. After transfection, the insulin content of secretion was detected by RIA. The insulin-producing cells were detected by Dithizon-staining. RESULTS: The production and the insulin secretion of insulin-producing cells differentiated from transfected pancreatic ductal epithelial cells were higher than the untransfected in vitro with significant difference (P<0.05). CONCLUSION: PDX-1 can promote rat pancreatic ductal epithelial cells to differentiate into insulin-producing cells obviously in vitro. | |||
TO cite this article:Liu Tao,Wang Chun-you,Yu Feng, et al. In vitro pancreas duodenal homeobox-1 enhances the differentiation of pancreatic ductal epithelial cells into insulin-producing cells[OL].[ 8 April 2009] http://en.paper.edu.cn/en_releasepaper/content/31194 |
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