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	1. Recent development of imidazolate-based N-coordinated ruthenium complexes
	HUANG Jiamin,ZHENG Wenjie
	Chemistry 03 June 2015
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	Abstract:The imidazole (im) derivative, [trans-RuIII(im)(DMSO)Cl4](Him), NAMI-A, (where Ru = ruthenium and DMSO = dimethylsulfoxide) has successfully completed I phase trial. The Ru complexes with imidazole and its derivatives have been widely used many field researches because the nitrogen atom(s) of imidazole or its derivatives can be deprotonated and can further bind the other metal ions into two-nuclear, three-neclear complexes or higher one-dimensional, two-dimensional, or three-dimensional frameworks. Thus, the current review gives a comprehensive mechanism of action of NH3-coordinated, imidazole-coordinated, areneimidazole-cooradinated, and biimidazole-coordinated Ru complexes, with the emphasis on their structure and application. These complexes are widely used in the whole fields of coordination chemical, medicinal chemical, physical chemical, catalytic chemistry, and supramolecular chemistry. Imidazole-based Ru complexes are very fascinating in these fields because of i) Ru intrinsic synthetic advantages and modular approach, ii) binding with DNA, albumin and transferrin, extracellular matrix, and enzymes, iii) the formation of hydrogen bond of imidazole, and iv) high catalytic activity for allylic alcohols into carbonyl derivates. The structure activity relationships, successful applications, and the perspectives for imidazoles-based Ru complexes will be discussed in detail in this review.
	TO cite this article:HUANG Jiamin,ZHENG Wenjie. Recent development of imidazolate-based N-coordinated ruthenium complexes[OL].[ 3 June 2015] http://en.paper.edu.cn/en_releasepaper/content/4645332


	2. Synthesis and binding studies of novel di-substituted phenanthroline compounds with genomic promoter and human telomeric DNA G-quadruplexes
	Chunying Wei,Yanbo Wang,Meiying Zhang
	Chemistry 08 January 2013
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	Abstract:Six novel di-substituted phenanthroline derivatives 5a-7a and 3b-5b have been prepared, and their binding interactions with human telomeric (h-telo) and the promoter c-kit2 and c-myc G-quadruplex DNAs were investigated. All the compounds are potent stabilisers of the G-quadruplex structures and the compounds 3b, 4b, and 5b exhibit a high G-quadruplex selectivity over duplex. The binding affinities of these compounds to G-quadruplex are higher than to duplex DNA. CD spectra show that the compound can induce the formation of anti-parallel structure of h-telo G-quadruplex. Each h-telo quadruplex binds two compound molecules by the end-stacking mode. Six new compounds are able to inhibit significantly the telomerase activity at lowμM concentration.
	TO cite this article:Chunying Wei,Yanbo Wang,Meiying Zhang. Synthesis and binding studies of novel di-substituted phenanthroline compounds with genomic promoter and human telomeric DNA G-quadruplexes[OL].[ 8 January 2013] http://en.paper.edu.cn/en_releasepaper/content/4511437


	3. Synthesis, visible light photocleavage, antiproliferative and cellular uptake properties of ruthenium complex [Ru(phen)2(mitatp)]2+
	Yu Huijuan,Yu Lin,Hao Zhifeng,Zhou Lihua,Xie Zhenming
	Chemistry 18 April 2012
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	Abstract:A new ruthenium complex [Ru(phen)2(mitatp)]2+ ( phen = 1,10-phenanthroline, mitatp = 5-methoxy-isatino[1,2-b]-1,4,8,9-tetraazatriphenylene) has been synthesized and characterized. The interaction of the complex with DNA has been studied and the results indicate that [Ru(phen)2(mitatp)]2+ could efficiently photocleave pBR322 DNA under irradiation at visible light and the singlet oxygen 1O2 was proved to be reactive species in the photocleavage process. The cytotoxicity has also been evaluated by MTT method, and [Ru(phen)2(mitatp)]2+ shows prominent anticancer activity against various cancer cells. Live cell imaging study and flow cytometric analysis demonstrate that the complex could cross cell membrane accumulating in the nucleus and inducing cell death by induction of G0/G1 cells cycle arrest and apoptosis.
	TO cite this article:Yu Huijuan,Yu Lin,Hao Zhifeng, et al. Synthesis, visible light photocleavage, antiproliferative and cellular uptake properties of ruthenium complex [Ru(phen)2(mitatp)]2+[OL].[18 April 2012] http://en.paper.edu.cn/en_releasepaper/content/4474481


	4. Controllable synthesis of BSA-conjugated hydroxyapatite micro-/nano- particles
	Fang Dan,Cao Ying,Yang Lin,Wang Kui,Wang Huajie
	Chemistry 24 November 2010
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	Abstract:Controllable synthesis of hydroxyapatite with different size and morphology has drawn more and more attention these days due to the Size/morphology-dependent cytotoxicity of hydroxyapatite in tumor treatments. In this study, a facile method was developed for the controllable synthesis of bovine serum albumin-conjugated micro- and nano- hydroxyapatite. Scanning electron microscope, Fourier transform infrared, energy dispersive system analysis and X-ray powder diffraction displayed that the pH value was the key factor affecting the morphology, size and crystal structure of products. The optimal pH value for the flocculatidn hydroxyapatite micro-crystals with size 1.82 ± 0.19 μm in the diameter and amorphous hydroxyapatite nanoparticles with size 167 ± 12 nm in the diameter was 7.97 and 6.5, respectively.
	TO cite this article:Fang Dan,Cao Ying,Yang Lin, et al. Controllable synthesis of BSA-conjugated hydroxyapatite micro-/nano- particles[OL].[24 November 2010] http://en.paper.edu.cn/en_releasepaper/content/4392328


	5. The Study of the Role of Glu 101 in Maintaining the Proper Conformation of Euplotes Octocarinatus Centrin
	Li Guoting,Wang Zhijun,Zhao Yaqin,Ren Liexiang,Yang Binsheng
	Chemistry 23 May 2006
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	Abstract:Glu is highly conserved as the first amino acid of E-helix of the EF-hand protein. In this paper, Glu 101, the first amino acid of the E-helix of the third EF-hand motif in EoCen was mutated to be Lys by the method of site direct mutation. TNS and Tb3+ were used as probes in the study of the effect of this mutation to the proper conformation of EoCen. Results indicate the mutation protein (E101K) displays an increased hydrophobic exposure surface and a different Tb3+ binding characteristic. It proves that the conformation of EoCen has been altered largely by this mutation. The general conditional binding constant of Tb3+ to the three loops of EF-hand sites I, II, III in E101K was calculated to be (5.64 ± 0.57) × 105 M-1.
	TO cite this article:Li Guoting,Wang Zhijun,Zhao Yaqin, et al. The Study of the Role of Glu 101 in Maintaining the Proper Conformation of Euplotes Octocarinatus Centrin[OL].[23 May 2006] http://en.paper.edu.cn/en_releasepaper/content/6761

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