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1. Using Mammospheres as a Model to Determine Protein Signatures Presented in Breast Cancer Stem Cells | |||
guifa li,yuxiangjiang,dongchen,wiwang,yukuncui,fukunzhao | |||
Biology 23 February 2009 | |||
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Abstract:The breast cancer stem cells have been proposed to underpin many types of breast Cancer. also,mammospheres have been widely employed to study breast cancer stem cells. In current study, we have used the approaches of Proteomics to study the altered protein expression in mammospheres from the most commonly used breast cancer cell line MCF-7. we have identified 34 differentially expressed proteins in Mammospheres from parental cells. Of these 34 proteins, only seven expressed higher in Mammosheres. We find that FKBP4 and GIPC1 which is high associated with insulin-like growth factor I receptor was low expressed in mammospheres. The two proteins and their implications in breast cancer drug resistance are currently under study in our laboratory. | |||
TO cite this article:guifa li,yuxiangjiang,dongchen, et al. Using Mammospheres as a Model to Determine Protein Signatures Presented in Breast Cancer Stem Cells[OL].[23 February 2009] http://en.paper.edu.cn/en_releasepaper/content/29434 |
2. Species difference in regional dispersal ability and neutral model | |||
Liu jiajia,Zhou ShuRong | |||
Biology 20 February 2009 | |||
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Abstract:The neutral assumption is fundamental yet controversial to neutral theory. In real communities, species may differ in regional dispersal probability not only because of stochasticity such as random sampling process, but also the dispersal ability itself varies considerably across species. In this paper, we relaxed the ecological equivalence assumptions of the neutral model by introducing difference into species’ regional dispersal ability. Adding slight difference in dispersal ability among species into neutral model dramatically reduces species richness and result in considerable deviation of species abundance distributions from those predicted by neutral model. Difference in species immigration ability, if there is, can overwhelm the role of random drift and make local community dynamics becomes deterministic. Species with higher regional dispersal ability tends to have higher relative abundance in local communities. However, species relative abundance distribution curves under species differences in immigration rate can be fitted well by neutral model. More investigations are needed before we understand the relative roles of species differences and neutrality in structuring ecological communities. | |||
TO cite this article:Liu jiajia,Zhou ShuRong. Species difference in regional dispersal ability and neutral model[OL].[20 February 2009] http://en.paper.edu.cn/en_releasepaper/content/29406 |
3. The apical-basalateral polarization of RPE | |||
Jia Yanjuan,Song Dexiao,Liu Yong,Gao Lan | |||
Biology 18 February 2009 | |||
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Abstract:Vertebrate retinal pigment epithelium (RPE) is a highly specialized epithelium with polarized membrane domains,with microvilli and junctional complexes on the apical pole and infoldings along the basolateral side, which express a morphological and functional polarity along their apical-to-basal axis. The loss of RPE polarity is associated with many degenerative eye diseases. Here, we highlight the polarized distribution of membrane protein and melanosome, TJs development, IPM and αPKC’s role and the alteration of RPE polarity in regeneration. Although RPE polarity has been studied a lot, which is at infant stage for treating degenerative eye diseases. So many morphological events and regulated mechanism still need to be elucidated in greater details from histological to molecular level, from development to adult, from nomal to mutation. | |||
TO cite this article:Jia Yanjuan,Song Dexiao,Liu Yong, et al. The apical-basalateral polarization of RPE[OL].[18 February 2009] http://en.paper.edu.cn/en_releasepaper/content/29249 |
4. Cerebellar fastigial nuclear inputs and peripheral feeding signals converge on neurons in the dorsomedial hypothalamic nucleus | |||
Bin Li,Guo Chunli,Tang Jing,Zhu Jingning,Jian-Jun Wang | |||
Biology 09 January 2009 | |||
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Abstract:Previous studies have indicated that neurons in the dorsomedial hypothalamic nucleus (DMN) receive feeding-related signals from the gastric vagal nerves, glycemia as well as leptin. On the other hand, it is intriguing that the cerebellum participates in regulating nonsomatic visceral activities including food intake via the direct cerebellohypothalamic projections. The present study was designed to examine, by using extracellular recordings in vivo in rats, whether the cerebellar fastigial nucleus (FN) could reach and converge with the feeding-associated gastric vagal, glycemia, and leptin signals onto single DMN neurons. Of the 200 DMN neurons recorded, 104 (52%) responded to the cerebellar FN stimulation, in which 95 (91.3%) were also responsive to the gastric vagal stimulation, suggesting a convergence of cerebellar FN and gastric vagal inputs on the DMN neurons. Moreover, a summation of responses was observed (n = 10) when the cerebellar FN and gastric vagal nerve were simultaneously stimulated. Among the 18 DMN neurons receiving convergent inputs from the cerebellar FN and gastric vagal nerves, 16 (88.9%) cells also responded to the systemic administrations of glucose and leptin. These results demonstrated that the cerebellar FN afferent inputs, together with the feeding signals from the gastric vagal nerves, blood glucose as well as leptin, converge onto single DMN neurons, suggesting that a somatic-visceral integration related to the feeding may occur in the DMN and the cerebellum may actively participate in the feeding regulation through the cerebellar FN-DMN projections. | |||
TO cite this article:Bin Li,Guo Chunli,Tang Jing, et al. Cerebellar fastigial nuclear inputs and peripheral feeding signals converge on neurons in the dorsomedial hypothalamic nucleus[OL].[ 9 January 2009] http://en.paper.edu.cn/en_releasepaper/content/27571 |
5. Histamine excites rat lateral vestibular nuclear neurons through activation of post-synaptic H2 receptors | |||
Jun ZHANG,Han Xiaohu,Li Hongzhao,Zhu Jingning,Jian-Jun Wang | |||
Biology 09 January 2009 | |||
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Abstract:Through whole-cell patch recordings in brainstem slices, the effects of histamine on neuronal activity of the lateral vestibular nucleus (LVN) were investigated. Bath application of histamine elicited a concentration-dependent excitation of both spontaneous firing (n = 19) and silent (n = 7) LVN neurons. Moreover, histamine induced a stable inward current in the LVN neurons (n = 5) and the histamine-induced depolarization of membrane potential persisted in the presence of tetrodotoxin (n = 4), indicating a direct postsynaptic effect of the histamine on the LVN neurons. Selective histamine H2 receptor antagonist ranitidine effectively blocked the histamine-evoked excitatory responses on the LVN neurons (n = 4), but selective histamine H1 receptor antagonist triprolidine did not (n = 4). In addition, selective histamine H2 receptor agonist dimaprit (n = 3) rather than 2-pyridylethylamine (n = 4), a selective histamine H1 receptor agonist, mimicked the excitatory action of histamine on LVN neurons. The results demonstrate that histamine excites the LVN neurons via postsynaptic histamine H2 receptors and suggest that the central histaminergic projection arising from the hypothalamus may modulate LVN neurons activity and actively influence the vestibular reflexes and functions. | |||
TO cite this article:Jun ZHANG,Han Xiaohu,Li Hongzhao, et al. Histamine excites rat lateral vestibular nuclear neurons through activation of post-synaptic H2 receptors[OL].[ 9 January 2009] http://en.paper.edu.cn/en_releasepaper/content/27566 |
6. Cerebellar modulation on feeding-related neurons in rat dorsomedial hypothalamic nucleus | |||
Jing-Ning Zhu,Li Hongzhao,Ding Yi,Jian-Jun WANG | |||
Biology 08 January 2009 | |||
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Abstract:Cerebellum has newly been implicated in much more nonsomatic functions other than motor control. Previous studies indicate that the cerebellum is involved in feeding regulation and the gastric vagal nerves transmit short-term meal-related visceral signals including cholecystokinin (CCK) into the hypothalamus. Recently, the dorsomedial hypothalamic nucleus (DMN) is believed to play an important role in feeding control. Here we investigate whether the inputs from cerebellar interpositus nucleus (IN) can reach and converge onto single DMN neurons with some feeding-related visceral signals, including gastric vagal inputs, CCK and blood glucose whose concentration is closely linked to food intake. Among the 259 DMN neurons recorded, 120 (46.3%) and 169 (65.3%) responded to the cerebellar IN and gastric vagal stimulations, respectively. Within the 120 DMN neurons responsive to the cerebellar IN stimulation, 98 (81.7%) also responded to the gastric vagal stimulus and a summation of the responses was observed further (n = 20), suggesting a convergence and interaction of cerebellar and gastric vagal inputs on the cells. Moreover, of the 98 cells receiving convergent inputs from cerebellar IN and gastric vagal nerves, 69 (70.4%) were identified to be glycemia-sensitive, in which 22 (68.8%) of the 32 tested neurons were also sensitive to systemic CCK. These results demonstrate that the DMN integrates somatic information forwarded by the cerebellar IN and visceral signals related to food intake, including gastric vagal, CCK and glycemia, and electrophysiologically reveal a novel cerebellohypothalamic IN-DMN pathway through which the cerebellum may actively participate in the short-term feeding regulation. | |||
TO cite this article:Jing-Ning Zhu,Li Hongzhao,Ding Yi, et al. Cerebellar modulation on feeding-related neurons in rat dorsomedial hypothalamic nucleus[OL].[ 8 January 2009] http://en.paper.edu.cn/en_releasepaper/content/27465 |
7. A Plausible Model of the Floral Phyllotaxis of Sunflower | |||
W.S. Yang,Zhao Rusheng | |||
Biology 15 December 2008 | |||
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Abstract:Pointing out that the published experimental facts regarding development of sunflower capitulum can be understood better if the capitulum meristem is similar in size with the shoot apical meristem (SAM) of Arabidopsis, and then assuming that it functions also similarly as the Arabidopsis SAM, a model is proposed for the floral phyllotaxis of sunflower, which consists of the following three key points. The primordium initiation process of sunflower capitulum is interpreted as, in terms of mathematics, being equivalent to a series of hyperbolic rotations. To take advantage of the unique character of the hyperbolic-rotation transformation of a hyperbolic object, so to make the hundreds of primordia well organized on the capitulum, the meristem must be able to initiate primordia with a divergence angle of around 137.5°, so to form a quasi-hyperbolic object. This is why meristems possessing this capability are chosen by natural selection in evolution. Although random errors in divergence angles do make the floral patterns only quasi-hyperbolic, but do not block their development into a floral phyllotaxis with a Fibonacci ratio like 89:55, because the errors can be reduced step by step and spontaneously in the hyperbolic-rotation growth process. | |||
TO cite this article:W.S. Yang,Zhao Rusheng. A Plausible Model of the Floral Phyllotaxis of Sunflower[OL].[15 December 2008] http://en.paper.edu.cn/en_releasepaper/content/26580 |
8. The computed tomography and gross anatomies of nasal cavity and sinuses in the Bactrian camel (Camelus bactrianus) | |||
Zhong-Tian Bai,Hong-Ju Wang,Jing-Chen Chen,Guo-Qiang Yuan,Lian-Lian Li,Jian-Lin Wang | |||
Biology 05 December 2008 | |||
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Abstract:The structures of nasal cavity and sinuses of the Bactrian camel and their adaptability to living environments were investigated using 64-slices spiral computed tomography (CT) and gross anatomy. The results show that the Bactrian camel owns large and complex concha, narrow nasal meatus and large sinuses in volume. All these properties may relate to its living conditions of frequent sand-storms and aridity. This will offer the important references to the research of nasal morphology and adaptive physiological mechanism to its environment. And the present results and methods present useful references to the construction of nasal airflow model in the Bactrian camel. | |||
TO cite this article:Zhong-Tian Bai,Hong-Ju Wang,Jing-Chen Chen, et al. The computed tomography and gross anatomies of nasal cavity and sinuses in the Bactrian camel (Camelus bactrianus)[OL].[ 5 December 2008] http://en.paper.edu.cn/en_releasepaper/content/26364 |
9. Hydrophobic Variety of Chromatin in Cellular processes | |||
Xiao-en Wang | |||
Biology 06 November 2008 | |||
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Abstract:The discrepancies of molecular structure between DNA and RNA result to their different nature. Deoxyribose constituting DNA is more hydrophobic than ribose constituting RNA. On the chemical principle of similar substances can be soluble with each other (SSSEO), here, I propose that the DNA, nucleoplasm, and decondensational state of chromatin are more hydrophobic than the RNA, cytoplasm, and condensational state, respectively. Based on this point, many biological processes, such as the disappearance and reappearance of nuclear envelope during division of eucaryote, the spontaneous exit of RNA to cytoplasm after synthesis within nucleus, and the relation between chemical modifications of chromatin and some important cellular processes, may be well explicated. | |||
TO cite this article:Xiao-en Wang. Hydrophobic Variety of Chromatin in Cellular processes[OL].[ 6 November 2008] http://en.paper.edu.cn/en_releasepaper/content/25495 |
10. Antifungal activity of five solanaceous glycoalkaloids and their mixtures against phytopathogenic fungi Cercosporella brassicae and Alternaria porri | |||
ZHAO Xue-song,GAO Ling,WANG Juan,XU Wenjing,BI Hongtao,ZHOU Yi-fa | |||
Biology 22 July 2008 | |||
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Abstract:The antifungal activity of five solanaceae glycoalkaloids solanine, chaconine, solasonine, solamargine and tomatine against phytopathogenic fungi Cercosporella brassicae and Alternaria porri has been evaluated. Tomatine showed the highest antifungal activity against C. brassicae and A. porri among five compounds, followed with chaconie, solamargine and solasonine, while solanine showed the lowest antifungal activity. Mixture of potato glycoalkaloids solanine and chaconine produced marked synergistic antifungal activity. The magnitude of synergisms is higher at lower concentrations than that at higher concentrations. The antifungal activity of individual glycoalkaloid against A.porri was relative low, even no activity, but the mixture of chaconine and solanine show significant synergism. There was no synergism between glycoalkaloids solasonine and solamargine from Solanum nigrum in inhibiting fungul growth. The mixtures of solamargine and chaconine, and solasonine and solanine both caused additive inhibition on the growth of fungi. | |||
TO cite this article:ZHAO Xue-song,GAO Ling,WANG Juan, et al. Antifungal activity of five solanaceous glycoalkaloids and their mixtures against phytopathogenic fungi Cercosporella brassicae and Alternaria porri[OL].[22 July 2008] http://en.paper.edu.cn/en_releasepaper/content/22992 |
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