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	1. Development of Mutation Sensitive Switch Assays for Preeclampsia-associated AGT Polymorphism
	LIU jinying,XING,Chungen,LI Kai
	Biology 28 March 2016
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	Abstract:AGT (angiotensinogen) gene polymorphisms are associated with the development of hypertension and preeclampsia. Two main polymorphisms of AGT gene are T174M and M235T. The purpose of this study is to develop assays for detecting T174M and M235T by a nanoscale mutation-sensitive switch consisting of high fidelity polymerase and phosphorothioate-modified allele specific primers in order to meet the technical requirement in application for large scale genetic screening and for non-invasive genotyping of maternal circulating DNA. The developed assays showed sensitivities of as low as 10 copies and specificities of more than three log scales for matched over mismatched templates by routine PCR and real-time PCR. These assays are rapid, accurate, and cost-efficient in genotyping AGT gene for large population for the purpose of genetic screening.
	TO cite this article:LIU jinying,XING,Chungen,LI Kai. Development of Mutation Sensitive Switch Assays for Preeclampsia-associated AGT Polymorphism[OL].[28 March 2016] http://en.paper.edu.cn/en_releasepaper/content/4682189


	2. Seed germination behaviour of six phylogenetically-related Caragana species reveals small phylogenetic constraints, but a strong relationship to the environment in which they evolved
	Wei-Nan Zhao,Xiang-Wen Fang
	Biology 16 December 2015
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	Abstract:The seed-germination of the six phylogenetically-related Caragana species that thrive in arid to humid regions was investigated in a series of controlled temperature and water regimes. C. korshinskii (from an arid area), C. intermedia and C. microphylla (from semi-arid areas) had rapid seed germination, a high final seed germination percentage (GP), a large decrease in GP with an increase in temperature, but germinated at water/osmotic potentials as low as -1.2 MPa. However, C. arborescens and C. biosi (from semi-humid areas) had slow seed germination, a low final GP, which did not change with increase in temperature, and had no seed germination at water/osmotic potentials below -1.0 MPa. Seeds of C. stipatata (from a humid area) did not germinate until the seed coat was cracked after cold (4 C) had been imposed for 18 months. Using light microscopy, gaps were observed between the macrosclereids of the seed coat of species from the arid, semi-arid, and one species from the semi-humid areas (C. arborescens), but not the second species from semi-humid area (C. biosi). Gaps were not observed between the brachysclereids of the species from the humid area. The results showed that seed germination behaviour was not strongly conserved phylogenetically in the Caragana genus, but was strongly related to their seed coat structure and the environment in which they evolved. We conclude that the observed seed germination responses play an important role in determining the distribution of these species in the different environments of China.
	TO cite this article:Wei-Nan Zhao,Xiang-Wen Fang. Seed germination behaviour of six phylogenetically-related Caragana species reveals small phylogenetic constraints, but a strong relationship to the environment in which they evolved[OL].[16 December 2015] http://en.paper.edu.cn/en_releasepaper/content/4671812

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	3. Complete nucleotide sequences and gene organization of the Mt. Mang Pit Viper (Zhaoermia mangshanensis) mtDNA
	GENG Zhangzhen,YAN Peng
	Biology 13 December 2015
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	Abstract:The complete mitochondrial DNA sequence of Mang Mountain Pit Viper (Zhaoermia mangshanensis) was determined by using the polymerase chain reaction (PCR) method in this study. The entire length of the complete mitochondrial genome is 17,628 base pairs (bp). Just like most snakes, besides 2 control regions (CRI and CRII), the nucleotide contains 37 coding genes, exactly, 13 protein-coding genes, 22 tRNA genes and 2 rRNA genes. The gene content, organization and arrangement of the new mtDNA are highly similar to those of other vipers reported so far. It confirms again to the order and rearrangement of two tRNA genes (tRNA-Pro and tRNA-LeuUUR), which differs from the typical organization found for many vertebrates. Duplication of the control region and translocation of the tRNALeu(UUR) gene are two notable features of the snake mt genome (except the scolecophidians: blindsnakes and threadsnakes).
	TO cite this article:GENG Zhangzhen,YAN Peng. Complete nucleotide sequences and gene organization of the Mt. Mang Pit Viper (Zhaoermia mangshanensis) mtDNA[OL].[13 December 2015] http://en.paper.edu.cn/en_releasepaper/content/4670835


	4. High EPHA4 outside-inside-out interactive neuro-induced regulation of growth through ALK-C9orf127-ARHGDIG
	ZHANG Liming,WANG Lin
	Biology 26 September 2015
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	Abstract:13 different Pearson mutual-positive-correlation EPHA4-activation molecular network was constructed from 53 overlapping of 166 GRNInfer and 70 Pearson under EPHA4 CC ≥0.25 in high human hepatocellular carcinoma (HCC) compared with low no-tumor hepatitis/cirrhotic tissues (HBV or HCV infection). Our identified EPHA4 outside-inside-out interactive molecular network showed ALK (anaplastic lymphoma receptor tyrosine kinase), C9orf127 (chromosome 9 open reading frame 127), ARHGDIG (Rho GDP dissociation inhibitor (GDI) gamma) in high HCC. EPHA4 outside-inside-out interactive terms network includes integral to plasma membrane, membrane, transmembrane receptor protein tyrosine kinase signaling pathway, nucleus, cytoplasm, mitochondrion, endoplasmic reticulum, plasma membrane, cell surface, integral to membrane, membrane fraction, cytoplasmic membrane-bound vesicle; neurogenesis, axon guidance; nervous system development, brain development, cell adhesion, cell-matrix adhesion, regulation of progression through mitotic cell cycle, regulation of growth, negative regulation of cell adhesion; nucleotide-binding, transmembrane receptor protein tyrosine kinase activity, receptor signaling protein tyrosine kinase activity, receptor activity, protein-binding, ATP-binding, transferase activity, protein-tyrosine kinase activity, ephrin receptor activity, Rho GDP-dissociation inhibitor activity, GTPase activator activity based on integrative GO, KEGG, GenMAPP, BioCarta and disease databases in high HCC. Therefore, we propose high EPHA4 outside-inside-out interactive neuro-induced regulation of growth through ALK-C9orf127-ARHGDIG in HCC.?????
	TO cite this article:ZHANG Liming,WANG Lin. High EPHA4 outside-inside-out interactive neuro-induced regulation of growth through ALK-C9orf127-ARHGDIG[OL].[26 September 2015] http://en.paper.edu.cn/en_releasepaper/content/4655855


	5. RhoGDIα negatively regulates the glioma stem cell maintenance through RhoA/ROCK1/FOXO1/Oct4 pathway
	Wu Fan,Han Wei,Hu Peishan,Li Dengke,Hu Yan,Qi Yingjiao,Yin Bin,Jiang Tao,Yuan Jiangang,Peng Xiaozhong
	Biology 15 July 2015
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	Abstract:Glioma stem cells (GSCs) are a subset of tumor cells that drive glioma initiation and progression. The molecular mechanisms underlying the maintenance of GSC are still poorly understood. Here we investigated the role of RhoGDIα in GSCs. Over-expression of RhoGDIα suppressed the self-renewal and promoted the differentiation of GSCs. Further data suggested RhoGDIα inhibited the transcription of Oct4 through RhoA/ROCK1/FOXO1 pathway. Moreover, inactivation of ROCK1 also decreased the self-renewal and Oct4 transcriptional activity, and rescued the effects caused by RhoGDIα knockdown. Our results indicate that RhoGDIα is involved in the maintenance of GSCs.
	TO cite this article:Wu Fan,Han Wei,Hu Peishan, et al. RhoGDIα negatively regulates the glioma stem cell maintenance through RhoA/ROCK1/FOXO1/Oct4 pathway[OL].[15 July 2015] http://en.paper.edu.cn/en_releasepaper/content/4650242


	6. Acute effects of TGFβ1 on neuronal excitability and possible involvement in the pain of rats with chronic pancreatitis
	Zhang Xiaoyu,Zheng Hang,Jiang Xinghong,Xu Guang-Yin
	Biology 06 May 2015
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	Abstract:Background: Transforming growth factor beta1 (TGFβ1) is upregulated in chronic inflammation, where it plays a key role in wound healing and promoting fibrosis. However, the role of TGFβ1 in nociceptive processing in primary sensory neurons remains unclear. The aim of this study is to investigate whether TGFβ1 plays a role in hyperalgesia in chronic pancreatitis (CP) and the underlying mechanisms. Methods: CP was induced in male adult rats by intraductal injection of trinitrobenzene sulfonic acid (TNBS). Pancreatic hyperalgesia was assessed by referred somatic behaviors to mechanical stimulation of rat abdomen. Dil dye injected into pancreas was used to label pancreas-specific dorsal root ganglion (DRG) neurons. Whole cell patch clamp recordings and calcium imaging were performed to examine the effect of TGFβ1 on acutely isolated pancreas-specific DRG neurons. Results: Intrathecal injection of TGFβ receptor I antagonist SB431542 attenuated abdominal hyperalgesia in CP rats. TGFβ1 application depolarized the membrane potential and caused firing activity of pancreas-specific DRG neurons. TGFβ1 application also reduced the rheobase, hyperpolarized action potential threshold and increased the number of action potentials evoked by current injection of pancreas-specific DRG neurons. TGFβ1 application increased the concentration of intracellular calcium of pancreas-specific DRG neurons, which was inhibited by TGFβ receptor I antagonist but not by TRPV1 receptor antagonist. Furthermore, intrathecal injection of TGFβ1 produced abdominal hyperalgesia in health rats. Conclusions: These results suggest that TGFβ1 enhances neuronal excitability and increases the concentration of intracellular calcium. TGFβ receptors are involved in abdominal hyperalgesia in CP. This and future study might identify a potentially novel target for the treatment of abdominal pain in CP.
	TO cite this article:Zhang Xiaoyu,Zheng Hang,Jiang Xinghong, et al. Acute effects of TGFβ1 on neuronal excitability and possible involvement in the pain of rats with chronic pancreatitis[OL].[ 6 May 2015] http://en.paper.edu.cn/en_releasepaper/content/4641932


	7. Microarray data uncover the genome-wide response to heat in rice post-meiosis panicle
	ZHANG Xianwen,CHEN Xinbo
	Biology 15 August 2014
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	Abstract:To comprehend the gene expression profile in rice panicle under high temperature, Agilent 4×44K rice oligo microarray experiments were carried out using post-meiosis stage rice panicle treated at 40 centigrade degree for 0 min, 10 min, 20 min, 60 min, and 2 hr. The time course differentially expressed genes under heat stress were mainly involved in binding, catalysis, stress response, and cellular process. The significantly changed genes during heat treatment were mainly up-regulated. Among heat-responsive genes, the predominant transcription factor gene families were Hsf, NAC, AP2/ERF, WRKY, MYB, and C2H2. The MapMan analysis demonstrated that, under heat treatment, the HR genes were enriched in the pathways related to biotic and abiotic stress, cell cycle, development, ubiquitin-proteasome system, lipid and secondary metabolisms. These data revealed the great importance of cross-talk and protein homeostasis in response to heat stress in rice panicle at post-meiosis stage.
	TO cite this article:ZHANG Xianwen,CHEN Xinbo. Microarray data uncover the genome-wide response to heat in rice post-meiosis panicle[J].


	8. A Geometric Morphometric Approach of Wing Shape Variation of Colour Polymorphs in the Scorpionfly Panorpa liui Hua (Mecoptera: Panorpidae)
	Feng Yanyan,Yan Baorong,Hua Yuan,Jiang Lu,Hua Baozhen
	Biology 29 May 2014
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	Abstract:Colour polymorphism is a common phenomenon in many groups of insects. This phenomenon allows adaptation to different environments, and is also one of the main reasons for synonymy in insect taxonomy practices. The scorpionfly Panorpa liui Hua is a widespread species in the northeastern region of China, with a typical yellowish-brown body and ground colour of wings. However, a black-bodied Panorpa (melanic morph) and a black-tailed Panorpa (intermediate morph) are frequently encountered sympatrically with the typical brown morph of P. liui, to which they are very similar in appearance. Geometric morphometric analyses were conducted on the variation of the right forewing shape with P. changbaishana and P. jilinensis as reference species. The results show that the wing shapes of the intermediate and melanic morphs are very similar to and difficult to separate from that of the typical morph of P. liui based on the canonical variance analysis, between-group PCA (principal component analysis) and the PCA. The partial Procrustes distance between the melanic morph and the typical P. liui is the smallest, indicating that they are the most similar on wing shape. The melanic morph and the intermediate morph are nearly the same on wing size, and larger than the typical morph of P. liui. Differences in wing morphology are described for these three morphs and indicate that geometric morphometric analyses of wing characters accurately classify individuals of the unknown specimens and can reliably discriminate between colour polymorphism groups in specific level. The reason of colour polymorphism and its possibility of causing synonyms in taxonomy are briefly discussed.
	TO cite this article:Feng Yanyan,Yan Baorong,Hua Yuan, et al. A Geometric Morphometric Approach of Wing Shape Variation of Colour Polymorphs in the Scorpionfly Panorpa liui Hua (Mecoptera: Panorpidae)[OL].[29 May 2014] http://en.paper.edu.cn/en_releasepaper/content/4599132


	9. Comparison of Sequence and Structure of Loop Regions in Lipases: Discovery of a Novel Mutable Domain
	Xu Yun,Shen Kunlong,Hu Suyuan,Wu Hongyi,Zhou Zhiliang,You Yuanming,Zhao Yi-Lei
	Biology 03 March 2014
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	Abstract:Lipases (EC 3.1.1.3) possess two critical conformations, "open" and "close", during their catalytic process. The conformational changes, caused by the flexible loop regions in the enzymes, determine selectivity, regioselectivity and stereoselectivity of substrates in the enzymatic reactions. However, the principles beneath the phenomenon have not been clearly understood thoroughly yet, in terms of mutability on these loop regions. This paper employed both sequence and structure bioinformatical methods to study lipases available in database, especially for loop regions such as the 'lid' domain that was widely reported to connect substrate selectivity. Unsurprisingly, the 'lid' domain is quite mutable in a group of lipases which are in a moderate similarity for sequence and structure. However, we have found a more mutable, even the most mutable, domain among these loop regions. Loop 9, a very close to C terminus, is ranked top 1. The new discovery may rationalize the coupling effect from colipase.
	TO cite this article:Xu Yun,Shen Kunlong,Hu Suyuan, et al. Comparison of Sequence and Structure of Loop Regions in Lipases: Discovery of a Novel Mutable Domain[OL].[ 3 March 2014] http://en.paper.edu.cn/en_releasepaper/content/4587910


	10. Promoting effect of licorice extract on induction of β-glucuronidase in Penicillium purpurogenum Li-3
	WANG Dong,HUANG Shen,DAI Dazhang,LI Chun,LIU Guiyan
	Biology 12 February 2014
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	Abstract:Penicillium purpurogenum Li-3, a fungus producing β-glucuronidase (PGUS), can modify glycyrrhizin (GL) to glycyrrhetinic acid monoglucuronide (GAMG) when grown in medium with GL as the sole carbon source. In order to improve the conversion rate of GL to GAMG and the yield of GAMG, licorice extract (LE) was added as an inducer to enhance the production of PGUS, and the influence of LE on the conversion rate of GL to GAMG was studied in this work. When the strain were grown in the medium containing LE and GL (concentration ratio was 2:3), the conversion rate of GL was 84.12% with a 38.18% increase and the yield of GAMG was 80.47% with an increase of 37.18% than the medium only containing GL at 48h and the enzyme activity of β-glucuronidase was also enhanced from 22.4U/ml to 82.3U/ml. The results showed that the induced expression of PGUS was highly improved when a certain amount of LE was added into the medium.?????
	TO cite this article:WANG Dong,HUANG Shen,DAI Dazhang, et al. Promoting effect of licorice extract on induction of β-glucuronidase in Penicillium purpurogenum Li-3[OL].[12 February 2014] http://en.paper.edu.cn/en_releasepaper/content/4585317

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